Chronicles of Young Scientists 

About: Chronicles of Young Scientists is an academic journal. The journal publishes majorly in the area(s): Population & Drug delivery. It has an ISSN identifier of 0975-9212. Over the lifetime, 140 publications have been published receiving 3031 citations.

Methods for the determination of limit of detection and limit of quantitation of the analytical methods

Abstract: The quality of an analytical method developed is always appraised in terms of suitability for its intended purpose, recovery, requirement for standardization, sensitivity, analyte stability, ease of analysis, skill subset required, time and cost in that order. It is highly imperative to establish through a systematic process that the analytical method under question is acceptable for its intended purpose. Limit of detection (LOD) and limit of quantification (LOQ) are two important performance characteristics in method validation. LOD and LOQ are terms used to describe the smallest concentration of an analyte that can be reliably measured by an analytical procedure. There has often been a lack of agreement within the clinical laboratory field as to the terminology best suited to describe this parameter. Likewise, there have been various methods for estimating it. The presented review provides information relating to the calculation of the limit of detection and limit of quantitation. Brief information about differences in various regulatory agencies about these parameters is also presented here.

Nanoemulsion: A new concept of delivery system

Abstract: Nanoemulsion has been identified as a promising delivery system for various drugs including biopharmaceuticals. Nanoemulsion is a heterogeneous system composed of one immiscible liquid dispersed as droplets within another liquid. The droplets size of nano emulsion is between 20 to 500 nm. Diameter and surface properties of droplets of nanoemulsion plays an important role in the biological behavior of the formulation. Small droplet sizes lead to transparent emulsions so that product appearance is not altered by the addition of an oil phase. In this paper various aspects of nanoemulsion have been discussed including advantages, disadvantages and methods of preparation. Furthermore new approaches of stability of formulation, effect of types and concentration of surfactant, process variables and method are also discussed to improve the stability of nanoemulsion formulation

An assessment of groundwater quality using water quality index in Chennai, Tamil Nadu, India

Abstract: Context : Water, the elixir of life, is a prime natural resource. Due to rapid urbanization in India, the availability and quality of groundwater have been affected. According to the Central Groundwater Board, 80% of Chennai's groundwater has been depleted and any further exploration could lead to salt water ingression. Hence, this study was done to assess the groundwater quality in Chennai city. Aim : To assess the groundwater quality using water quality index in Chennai city. Materials and Methods: Chennai city was divided into three zones based on the legislative constituency and from these three zones three locations were randomly selected and nine groundwater samples were collected and analyzed for physiochemical properties. Results: With the exception of few parameters, most of the water quality assessment parameters showed parameters within the accepted standard values of Bureau of Indian Standards (BIS). Except for pH in a single location of zone 1, none of the parameters exceeded the permissible values for water quality assessment as prescribed by the BIS. Conclusion: This study demonstrated that in general the groundwater quality status of Chennai city ranged from excellent to good and the groundwater is fit for human consumption based on all the nine parameters of water quality index and fluoride content.

Moringa : The herbal gold to combat malnutrition

Abstract: This document is aimed to describing the potential benefits of the Moringa tree as a nutrient. Moringa tree can be utilized in treating the malnutrition in a local and cost-effective manner. Malnutrition causes a great deal of human suffering and is associated with more than half of all deaths of children worldwide. Malnutrition severely affects the socio-economic development of a nation because a work force that is stunted both mentally and physically may have a reduced work capacity. Thus nutrition plays an important role in the reproduction of poverty from one generation to the next. Not only is the Moringa oleifera tree extraordinary in that all parts of the tree are edible, but the most amazing aspect of the tree is its exceptionally high nutritional value. The leaves of the Moringa tree are an excellent source of vitamin A, vitamin B vitamin C and other minerals. The leaves are also an outstanding source of calcium, protein, potassium and iron. The content of amino acids such as methionine and cystine is also high. Carbohydrates, fats and phosphorous content are low making this one of the finest plant foods to be found. Present review focuses on the potential benefits of Moringa oleifera in treatment of malnutrition.

Multitude potential of wheatgrass juice (Green Blood): An overview

Abstract: Wheatgrass is the young grass of the common wheat plant Triticum aestivum Linn., family Poeaceae (Graminae). It is commonly known as the green blood due to its high chlorophyll content which accounts for 70% of its chemical constituents. It contains a plethora of vitamins, minerals, amino acids and vital enzymes like superoxide dismutase and cytochrome oxidase. The vitamin content makes it an important adjuvant in anti-allergic and anti-asthmatic treatment, while the enzymes play a pivotal role in the anticancer approach of this herbal drug. A notable feature of the wheatgrass juice is its bioflavonoid content which are the naturally occurring antioxidants and ac­count for many of its clinical utilities such as management of inflammatory bowel disease and as a general detoxi-fier. However, the most remarkable feature of the wheatgrass juice is its high chlorophyll content. Chlorophyll bears structural similarity to hemoglobin and has been found to regenerate or act as a substitute of hemoglobin in hemoglobin deficiency conditions. This might be the reason behind the utility of wheatgrass in clinical conditions like thalassemia and hemolytic anemia. The present article focuses onto the various studies emphasizing the multi­tude potentials of wheatgrass.