Showing papers in "Clinical Therapeutics in 2009"

TL;DR: Treating pain during childhood immunization has the potential to reduce distress during the procedure and greatly improve satisfaction with the immunization experience through more positive experiences for children and their families.

TL;DR: Evidence suggests that breathing exercises, child-directed distraction, nurse-led distraction, and combined cognitive-behavioral interventions are effective in reducing the pain and distress associated with childhood immunizations.

TL;DR: The efficacy and tolerability of tapentadol IR 50 and 75 mg was noninferior to that of oxycodone HCl IR 10 mg; however, the incidence of selected gastrointestinal AEs (nausea, vomiting, and constipation) was significantly lower for both doses ofTapentadl IR compared with oxycod one HClIR 10 mg (nominal P < 0.001).

TL;DR: There was a significant positive relationship between reduction in LDL-C and reduction in the risk for major cardiovascular events and Random effects meta-regression analysis of these trials support and extend the findings of the CTTC.

TL;DR: Although several new agents have shown promise in treating AML, it is unlikely that these agents will be curative when administered as monotherapy; it is more likely that they will be used in combination with other new agents or with conventional therapy.

TL;DR: The purpose of this review was to determine the effectiveness of physical interventions and injection techniques for reducing pain during vaccine injection in children, and a qualitative approach was used for data analysis.

TL;DR: In these opioid-tolerant patients with cancer, INFS at doses of 50, 100, and 200 microg was associated with an onset of activity at 10 minutes and effective treatment of breakthrough pain compared with placebo.

TL;DR: In this study of Medicare Part D enrollees with diabetes, patients aged <65 years, women, black or Hispanic patients, and those with higher comorbidity scores were more likely to be nonadherent to medications.

TL;DR: This meta-analysis of 7 randomized controlled trials suggests that pramipexole had a beneficial effect on mood and motivational symptoms in PD patients who did not have major depressive disorder.

TL;DR: Assessment of the effectiveness and tolerability of various pharmacologic and combined interventions for reducing the pain experienced by children during immunization found the use of topical local anesthetics was associated with less pain than was placebo.

TL;DR: Treatment with varenicline was generally well tolerated in study populations with no major comorbidities and in double-blind clinical trials of vareniline, nausea was the most frequently reported AE.

TL;DR: The effects of exenatide on glycemic control, weight, and insulin dose in patients with T2DM treated with insulin was examined and changes in insulin TDD during the 12- to 18-month and 18- to 27-month intervals were not statistically significant.

TL;DR: In the intent-to-treat population, median morphine use was significantly reduced during the first 24 hours after administration of the study drug in patients who received ibuprofen 800 mg IV q6h (by 22% vs placebo; P = 0.030).

TL;DR: In this paper, the authors compared the efficacy and tolerability of topiramate and amitriptyline in the prophylaxis of episodic migraine headache in adults with 3 to 12 migraines per month.

TL;DR: The results indicate that 39.7% of adult patients with type 2 DM in the United States had some degree of chronic kidney disease, as measured in NHANES IV for the years 1999 through 2004, which reinforces the need to screen patients withtype 2 DM for CKD and to prevent the cascade of events leading to nephropathy by implementing adequate glycemic and blood pressure controls, especially in the early stages of CKD.

TL;DR: An in-depth review of the clinical pharmacology of the main antiandrogens used in the treatment of the paraphilias is provided, as well as a discussion of the relevant clinical case reports, case series, and controlled trials.

TL;DR: Once-daily liraglutide was effective and well tolerated when used as monotherapy or in combination with OADs in patients with type 2DM, and is therefore a promising new treatment option for the management of type 2 DM.

TL;DR: The efficacy of 7-day buprenorphine patches was noninferior to that of prolonged-release tramadol tablets and both treatments were associated with a clinically meaningful reduction in pain from baseline to study completion.

TL;DR: The available evidence suggests that clinical efficacy in breast cancer is limited to HER2+ disease, and lapatinib monotherapy was well tolerated, although the response rate was low in patients with advanced breast cancer.

TL;DR: This retrospective, observational pilot study of usual community practice supports the findings from prospective trials that resistant hypertension is an important clinical problem and more effective management is needed to enable patients with, or at risk for, resistant hypertension to achieve BP goals.

TL;DR: The available evidence suggests that SSRIs and other serotonergic/noradrenergic antidepressants should be used with caution during pregnancy, with careful follow-up of infants exposed to these agents in utero.

TL;DR: Tapentadol appears to be a well-tolerated and effective analgesic for the treatment of moderate to severe acute pain.

TL;DR: Lidocaine patches were effective in, and highly acceptable to, these patients with MPS and high tissue hypersensitivity, and effects at muscle trigger points and target areas were greater with infiltration.

TL;DR: Whether insulin detemir (detemir) was noninferior to insulin glargine (glargine) as the basal insulin in a basal-bolus regimen, with insulin aspart as the mealtime insulin, in terms of glycemic control at the end of 52 weeks in patients with type 1 diabetes mellitus (T1DM) was determined.

TL;DR: In this study, the burden of anemia and thrombocytopenia in a large cohort of patients undergoing chemotherapy for solid tumors in an outpatient oncology clinic in 2000-2007 remained high.

TL;DR: There is insufficient evidence to form any recommendations concerning fever in children with other chronic conditions, but caution is advised in cases of severe hepatic/renal failure or severe malnutrition.

TL;DR: From the perspective of the UK National Health Service, thromboprophylaxis with dabigatran etexilate was cost-saving compared with enoxaparin 40 mg once daily, with comparable efficacy and safety profiles.

TL;DR: There was a high prevalence of the prescribing of potentially inappropriate medications at ambulatory care visits by elderly patients in Taiwan in 2001-2004 and its influence on health care resource utilization was investigated.

TL;DR: Current evidence suggests that GAD is associated with substantial economic and humanistic impact on patients and health care systems.

TL;DR: Patients initiating TNF-antagonist treatment for RA with infliximab incurred annual medication costs that were nearly 30% greater than costs in those initiating therapy with adalimumab or etanercept, in part because of the significantly greater rate of GTED in inflIXimab recipients.