Showing papers in "Clinical Toxicology in 1969"
TL;DR: In this article, the authors discuss the effects of tricyclic antidepressants on 100 patients who were poisoned by cyclic anti-antidepressants and the management of 100 patients.
Abstract: (1969). Acute Poisoning by Tricyclic Antidepressants: Clinical Features and Management of 100 Patients. Clinical Toxicology: Vol. 2, No. 4, pp. 403-421.
106Â citations
TL;DR: In this article, the authors discuss the possibilities of new fantasy-enhancing drugs and their potential applications in the treatment of cancer and other diseases, and propose a framework for their evaluation.
Abstract: (1969). Psycotherapeutic Possibilities of New Fantasy-Enhancing Drugs. Clinical Toxicology: Vol. 2, No. 2, pp. 209-224.
42Â citations
TL;DR: In this article, factors affecting the Cardiotoxic potential of Cobalt are discussed, and the authors propose a method to identify the most important factors that affect the potential of cobalt.
Abstract: (1969). Factors Affecting the Cardiotoxic Potential of Cobalt. Clinical Toxicology: Vol. 2, No. 3, pp. 257-271.
30Â citations
TL;DR: A comparison with beer drinkers' cardiomyopathy was made by as discussed by the authors. But the authors did not consider the effects of alcohol consumption on the pathology of experimentally induced Cobalt Cardiomyopathies.
Abstract: (1969). The Pathology of Experimentally Induced Cobalt Cardiomyopathies. A Comparison with Beer Drinkers' Cardiomyopathy. Clinical Toxicology: Vol. 2, No. 3, pp. 273-287.
22Â citations
TL;DR: In this article, physical vs. psychological dependence and tolerance in high-dose methamphetamine abuse is discussed. But the authors do not consider the effects of high dosage on mental health.
Abstract: (1969). Physical vs. Psychological Dependence and Tolerance in High-Dose Methamphetamine Abuse. Clinical Toxicology: Vol. 2, No. 1, pp. 99-103.
17Â citations
TL;DR: In this article, the authors present a study of the effects of hydrogen sulfide poisoning in a sewer gas environment, showing that it can result in a significant reduction in lung cancer.
Abstract: (1969). Sewer Gas: Hydrogen Sulfide Intoxication. Clinical Toxicology: Vol. 2, No. 4, pp. 383-386.
16Â citations
TL;DR: (1969).
Abstract: (1969). The Effect of Dosage Form and Route of Administration on the Absorption and Excretion of Acetylsalicylic Acid in Man. Clinical Toxicology: Vol. 2, No. 1, pp. 111-127.
13Â citations
11Â citations
TL;DR: It has been shown that desipramine is the active metabolite of the more widely used imipramines, Tofranil, which is currently used in children for enuresis and in adults for its antidepressant effect.
Abstract: Desipramine hydrochloride (commercially known as Pertofrane, Geigy, Norpramine, Lakeside), is currently used as an antidepressant in adults It has been shown that desipramine is the active metabolite of the more widely used imipramine, Tofranil (Geigy). 'his metabolite is derived from imipramine in vivo by the removal of one methyl group from the sidechain nitrogen [l] (Fig. 1). Tofranil is currently used in children for enuresis and in adults for its antidepressant effect. for the passage of catecholamines across the cellular membrane of adrenergic neuron bodies, axom, and terminals. (Fig. 2) 'Thus imipramines have an anti-adrenergic drug response. This is in contrast to reserpine which selectively blocks the storage mechanism of catecholamines in the adrenergic neuron's storage granules [2]. desipramine hydrochloride [3-121 (Table 1). Ten of these are acute overdosage with the now classical picture of cardiac and central nervous system toxicity (Table 2). The cardiac toxicity usually manifests itself an hour or two after ingestion with hypotension. This may be accompamed or followed with alterations in cardiac rhythm. These alterations can be either a disturbance of conduction or excitability of the cardiac muscle. The conduction defects have been reported at several levelsfrrst degree atrio-ventricular block, bundle branch block, and intraventricular disturbances of conduction. The latter are the most usual and
11Â citations
11Â citations
TL;DR: In this article, Diphenoxylate-atropine (Lomotil) poisoning was investigated. But the authors focused on the poisoning of lomotils.
Abstract: (1969). Diphenoxylate-Atropine (Lomotil) Poisoning. Clinical Toxicology: Vol. 2, No. 4, pp. 377-382.
TL;DR: The effects of diets containing from 0 to 81 percent casein on the acute oral toxicity of Diazinon were studied in this paper, where the effects of casein were investigated.
Abstract: (1969). The Effects of Diets Containing from 0 to 81 Per Cent Casein on the Acute Oral Toxicity of Diazinon. Clinical Toxicology: Vol. 2, No. 3, pp. 295-302.
TL;DR: The Chemical of Social Change: DDT: The Chemical of social change as mentioned in this paper was the first publication of DDT as a chemical of change in the United States, 1969, Vol. 2, No. 4, pp. 359-370.
Abstract: (1969). DDT: The Chemical of Social Change. Clinical Toxicology: Vol. 2, No. 4, pp. 359-370.
TL;DR: Increased attention in recent years to poisonings caused by cholinesterase inhibitors such as organophosphate and carbamate insecticides, drugs, and a large number of organic phosphorus esters used m industrial processes, has led to the refinement of rapid and reliable means of cholinersterase assay for human and animal blood specimens.
Abstract: Increased attention in recent years to poisonings caused by cholinesterase inhibitors such as organophosphate and carbamate insecticides, drugs, and a large number of organic phosphorus esters used m industrial processes, has led to the refinement of rapid and reliable means of cholinesterase assay for human and animal blood specimens. Because mild clinical cases of antiche linesterase poisoning may mimic a variety of commonly encountered diseases it is useful to have available reliable tests for assessing the cholinesterase status of patients with histories suggesting possible exposure to cholinesterase inhibitors. Cholinesterase assays of the usual type depend upon the general reaction scheme illustrated in Fig. 1. Hydrolysis of acetylcholine (or other esters of choline) by the enzyme results in the production of free acetic acid. Hydrogen ion arising from dissociation of the acetic acid may be measured by several techniques, some of which arc also listed in Fig. 1. Rate of acetic acid production by the enzyme from the substrate can be quantitated to give an index of the cholinesterase activity in the specimen. Choice of an assay method for toxicological use should depend pnmarily on the demand for cholinesterase testing whch will be met by
TL;DR: The role of specialized information centers in toxicological information systems was discussed in this article, where the authors discuss the role of the specialized information center in toxicology information systems and their role in the identification of carcinogens.
Abstract: (1969). The Role of Specialized Information Centers in Toxicological Information Systems. Clinical Toxicology: Vol. 2, No. 1, pp. 105-109.
TL;DR: In this paper, the authors discuss the effects of severe barbiturate poisoning and contrasts in management in clinical toxicology: Vol. 2, No. 2 (No. 2), pp. 133-142.
Abstract: (1969). Severe Barbiturate Poisoning. Contrasts in Management. Clinical Toxicology: Vol. 2, No. 2, pp. 133-142.
TL;DR: In this paper, the red cell profile in the health supervision of lead workers was investigated and shown to be inadequate for lead workers. But this was not the case for all workers.
Abstract: (1969). Inadequacies of the Red Cell Profile in the Health Supervision of Lead Workers. Clinical Toxicology: Vol. 2, No. 3, pp. 249-256.
TL;DR: In this article, the authors discuss the Sacramental Aspects of Drug Usage and their relationship with drug usage in clinical toxicology: Vol.2, No. 2, pp. 171-192.
Abstract: (1969). Sacramental Aspects of Drug Usage. Clinical Toxicology: Vol. 2, No. 2, pp. 171-192.
TL;DR: In this article, Pesticides and their contributions to Chemical Epidemiolog have been discussed, including their contribution to chemical epidemiology, and their role in the development of epidemiology.
Abstract: (1969). Pesticides and Their Contributions to Chemical Epidemiolog. Clinical Toxicology: Vol. 2, No. 4, pp. 435-443.
TL;DR: A Computer-Based Poison Control Information System Clinical Toxicology: Vol 2, No 2, pp 149-157 as mentioned in this paper, 1969] was published by the American Chemical Society (ACS).
Abstract: (1969) A Computer-Based Poison Control Information System Clinical Toxicology: Vol 2, No 2, pp 149-157
TL;DR: In this paper, recommended reference books for Poison Control/Information Centers are presented. But they do not discuss the use of poison control/information centers in clinical toxicology: Vol. 2, No. 2 (No. 2), pp. 165-169.
Abstract: (1969). Recommended Reference Books for Poison Control/Information Centers. Clinical Toxicology: Vol. 2, No. 2, pp. 165-169.
TL;DR: In this article, the authors discuss poisonous plants and plant-caused emergencies in the field of Phytotoxicology, and present a method to identify the most poisonous plants.
Abstract: (1969). Phytotoxicology. II. Poisonous Plants and Plant-Caused Emergencies. Clinical Toxicology: Vol. 2, No. 2, pp. 143-148.