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Showing papers in "Contraception in 1971"


Journal ArticleDOI
TL;DR: These findings both confirmed and extended Haberlandt's concept of hormonal sterilization when it was found during the 1930's that estrogens in large quantities interfere with tubal and uterine egg transport and with the action of progesterone upon the endometrium.

66 citations


Journal ArticleDOI
TL;DR: Intravaginal administration of prostaglandins E 2 and F 2α in twelve women who had passed their expected day of menstruation by two to seven days was carried out and induced menstruation in eleven women.

57 citations


Journal ArticleDOI
TL;DR: Legal abortion was induced in 37 pregnant women in the second trimester by intra-amniotic administration of prostaglandin F 2α demonstrating a marked and prolonged stimulatory effect on the uterus.

57 citations


Journal ArticleDOI
TL;DR: Melatonin reduced the number of rats that ovulated and prevented the rise in plasma luteinizing hormone which occurred in the majority of the control animals at 57 hours after PMS administration.

37 citations


Journal ArticleDOI
TL;DR: Findings on the influence of copper and iron on human sperm motility were investigated in vitro under contraceptive aspects and consideration of these findings as the basis for new chemo-mechanical methods of vaginal contraception is discussed.

35 citations


Journal ArticleDOI
TL;DR: A clear dissociation of the dose of antiandrogen needed to cause selective inhibition of epididymal function without interference with libido or the functions of the testes and accessory glands is demonstrated and indicates a new approach to control of fertility in the male.

33 citations


Journal ArticleDOI
TL;DR: This medication has an application in family planning practice for women who do not plan to have more children because it is a long-acting parenteral female contraceptive agent.

28 citations


Journal ArticleDOI
TL;DR: The data suggest that fertility may be inhibited in rats by administration of estrogens in highly uterotrophic doses or by treatment with compounds which antagonize the endogenous estrogen required for implantation and maintenance of pregnancy.

27 citations


Journal ArticleDOI
TL;DR: It is concluded that these implants at the doses tested in this study can reduce fertility for periods up to 1 year but their acceptability as a contraceptive method in humans is limited mainly by their low effectiveness and the increased medical risk associated with method failures.

25 citations


Journal ArticleDOI
TL;DR: The presumed biologically inert IUD material seems to provoke an acute inflammatory response which is probably the forerunner of macrophage accumulation, and changes in the IUD itself also occur.

24 citations


Journal ArticleDOI
TL;DR: Women taking oral contraceptives exhibited significantl lower platelet ascorbic acid levels than controls at two weeks after both groups had been placed on a low Vitamin C diet, which could contribute to the increased incidence of thromboembolic disease.

Journal ArticleDOI
TL;DR: The concurrent administration of 1.0 or 3.0 mg daily of norethisterone acetate with the 50μg daily dose of ethinylestradiol had little extra effect on the serum proteins, with the exception of total iron-binding capacity, which showed a marked increase.

Journal ArticleDOI
TL;DR: The administration of mestranol to guinea pigs resulted in a marked reduction of the ascorbic acid concentration in their blood plasma and an even greater reductionIn their blood vessels, which could lower the negative potential of the blood vessel wall and might therefore predispose to intravascular thrombosis.

Journal ArticleDOI
TL;DR: The results of this study indicate that the intravenous administration of prostaglandins E 2 and F 2α may be of benefit in terminating pregnancy between 13 and 16 weeks gestation.

Journal ArticleDOI
TL;DR: 148 women (aged 14-48 years) 4-weeks post-partum were tested to determine glucose and insulin levels before and after 6 months of treatment with an oral contraceptive taken in routine cyclic manner.

Journal ArticleDOI
TL;DR: Vaginal contraceptive foam was used by 2,932 women for 28,322 cycles and the pregnancy rate, 3.98 pregnancies/100 women-years, was relatively low for a vaginal contraceptive.

Journal ArticleDOI
TL;DR: A review of studies conducted on the possible influence on reproductive fertility that may be imposed by immune mechanisms is presented and the major topics discussed include: 1) immunological aspermatogenesis and orchitis 2) sperm antibodies in humans and 3) reduction of fertility by means of immunization.

Journal ArticleDOI
TL;DR: In this article, the attitudes toward and knowledge of reproductive biology and pathology in ancient Greece myths are examined, in order to discover the attitudes towards fertility and pathology, and to understand how women brought forth of their own accord and solely responsible for the continuation of the species.

Journal ArticleDOI
TL;DR: Human alpha 1 -antitrypsin preparations inhibit rabbit sperm acrosomal protease using BAEE and gelatin as substrate and shows a progressive kinetics of inhibition in contrast to the trypsin kallikrein inhibitor from bovine lung that reacts immediately.

Journal ArticleDOI
Gert Heinen1
TL;DR: In this article, the authors make an attempt to minimize the daily intake of estrogen to the lowest effective amount that does not cause bleeding abnormalities, along with properly selected progestin, such low doses of estrogen will provide dependable contraception.

Journal ArticleDOI
TL;DR: In this article, a prospective study was conducted to evaluate the effectiveness of the Dalkon Shield on nulliparous and 978 multiparous patients, and the cumulative Life Table rates after 9 months for expulsion and pregnancy were 1.02% and 1.06%, respectively.

Journal ArticleDOI
TL;DR: It was noticeable, however, that sperm penetration does not become abolished in the progestagen group up to 3–4 cm from the sperm-mucus contact point: at this distance a “STOP” of migration was constantly observed.

Journal ArticleDOI
TL;DR: It was observed that the immune response in groups using steroidal contraceptives was considerably lower than that of the control.

Journal ArticleDOI
TL;DR: The differences in the rates of continuation between oral and loop users suggests that there are fundamental differences between these methods of contraception.

Journal ArticleDOI
TL;DR: Two hypotheses for the difference in continuation are offered: Patients wanting a temporary contraceptive method for purposes of child spacing may select orals; patients wanting a more permanent method to limit family size may select the IUD.

Journal ArticleDOI
TL;DR: It is demonstrated that anIUFB can act as an effective postconceptional type of contraceptive in rats and it is suggested that the antifertility effect of an IUFB insertion on day 3 may be mainly due to partial inhibition of uterine responses to ovarian hormones and that of an inserted on day 4 may be main due to an inhibitory influence of decidual change on implantation.

Journal ArticleDOI
TL;DR: Treatment of day 8 pregnant rats for 3 days with 30 mg aminoglutethimide, an inhibitor of steroid biosynthesis, did not affect gestation but when administered with as little as 0.1 μg of estradiol-17β, abortion occurred in 50% of the animals.

Journal ArticleDOI
TL;DR: The main side effect was irregular bleeding, although headache, nausea and abdominal pain were also noted, and only 9.6% of these women discontinued using this method of contraception because of side effects.

Journal ArticleDOI
TL;DR: Contraceptive activity achieved by 30 μg of daily administration of d-Norgestrel may be related to selective endometrial concentration of this compound, which was not seen previously for progesterone or chlormadinone acetate.

Journal ArticleDOI
K.T. Kirton1, A.D. Forbes1
TL;DR: Abortions were induced in pregnant rhesus monkeys by injection of 1 or 5 mg of PGF 2α into the amniotic sac, indicating advantages for this route of administration over other conventional routes.