Showing papers in "Contraception in 1973"

TL;DR: In this paper, norgestrel was incorporated into a solid matrix of poly-L-lactic acid and its rate of release was measured in in vitro and in vivo.

TL;DR: Evidence of coitus-induced ovulation in humans is reviewed and there is a need for further biochemical statistical and demographic analyses of the frequency and sociologic importance of coitomimetic stimuli in humans.

TL;DR: In this paper, a combination therapy of progestin and testosterone was carried out and the effects of this treatment on spermatogenesis and plasma testosterone (T) levels were studied.

TL;DR: It is suggested that danazol plus relatively small doses of testosterone may prove to be an effective and safe male contraceptive.

TL;DR: Marked reduction of sperm count occurred in eight fertile men bearing subdermal Silastic capsules containing testosterone who received 50 mg of either norgestrienone or R 2323 twice weekly per os, suggesting one of these nor-steroids may be used for a male contraceptive pill.

TL;DR: Main side-effects were cycle disorders consisting chiefly of shortened cycles and break-through bleeding, however, the incidence of irregular bleeding did not vary significantly with the different doses and the acceptability of the method was very rewarding.

TL;DR: Data indicate that a continued autoimmune aspermatogenesis or hyposperMatogenesis occurs rapidly in vasectomized guinea pigs, similar to that found in male guinea pig immunized with washed isologous spermatozoa and complete Freund's adjuvant.

TL;DR: The three to four hours-long latent period required for the inhibition of sperm motility by copper suggests that immediate immobilization of sperm is not a major mechanism of action of the copper IUD in the human.

TL;DR: Plasma estrogen was found to rise significantly at the end of each 12-week injection period, indicating continuation of cyclic ovarian activity despite the medroxyprogesterone, which apparently does not accumulate in the body.

TL;DR: The use of 15-me-PGF 2a seems to offer certain advantages of practical significance, and the degree of uterine stimulation and abortifacient efficacy of a single intra-amniotic injection of prostaglandin is evaluated.

TL;DR: The daily treatment with 25 mg of NET for three weeks followed by 25 mg once a week decreased the total sperm count and increased the percentage of abnormal spermatozoa and the treatment had no effect on libido or potency.

TL;DR: Although both types of contraceptives were instrumental in bringing about decreases in protein, fat and calcium content of milk, only the decrease registered with combination therapy was found to be statistically significant.

TL;DR: A life-table return-of-fertility rate of 82 percent at the end of 14 months was found, suggesting that return of fertility is not as great a problem as had been anticipated.

TL;DR: Injection of the HCG caused a dramatic rebound in these plasma steroid levels indicating the prevention of corpus luteum inhibition by DES in the presence of adequate amounts of HCG, and further research is needed to determine if an estrogen can be found with similar corpus lutesum inhibitory effectiveness but without the side effects of DES.

TL;DR: The responsiveness measured in terms of increase in plasma LH concentrations was lowest during the early and mid-follicular phase, generally highest around the spontaneous LH surge and was higher during the late-luteal phase than during the follicular phase.

TL;DR: The data indicate that this antiserum was generated in female rabbits by repeated intradermal injections of LRF-bovine serum albumin (BSA) conjugate emulsified in Freund's complete adjuvant is appropriate for biological studies regarding gonadotropin release in addition to its use in developing a radioimmunoassay for LRF.

TL;DR: Vaginal administration of PGE 2 is not superior to PGF 2 α for termination of early pregnancy because of the high frequency of adverse side effects and relatively low efficacy, and the administration ofPGE 2 suppositories is not advantagous to the operative termination ofEarly gestation.

TL;DR: This study provided corroborative evidence to explain the intrinsic failure rate of sonography for both the detection and typing of IUDs located within the uterus.

TL;DR: Only serotonin caused significant reduction in weight of the testis, but also gave rise to an increase followed by a decrease in prostatic weight, and spermatogenesis was drastically impaired following treatment with this indole.

TL;DR: The pregnancy, expulsion and removal rates in the United Kingdom study are higher than those reported in the American studies and a comparison is made with the two largest sizes of Lippes Loop fitted in both the United States and the United UK.

TL;DR: Adult male rats were given intratesticular injections of phosphate buffer, prostaglandins F 2α THAM or E 2 in volumes of 0.03 ml for a single testis either bilaterally or unilaterally, and weights of testes as well as of accessory sex glands were lower in rats treated with PGF 2α or E2 .

TL;DR: It is concluded that according to the conditions of these experiments, copper wire does not influence reproductive function and produces no teratological effects in rats, hamsters and rabbits.

TL;DR: A new technique of tubal occlusion by electrocauterization of the intramural portion of the Fallopian tube is described, where the electrode is passed into the tube under direct vision control through hysteroscopy and the tissue alterations produced during the cauterization procedure are clearly seen.

TL;DR: In this paper, the authors found that insertion of the endouterine Copper-T device (model TCu 200) immediately after 196 legal abortions in the first trimester was not found to change the incidence or the type of early somatic complications of the abortions as compared to the complications in a control group of 436 women.

TL;DR: In a case study of ten fertile women receiving a single intrauterine instillation of a suspension of Quinacrine, the six patients who did not have a hysterectomy 5 to 6 days later were found to have non-patent tubes when tested at least three weeks post-instillation.

TL;DR: Variations of serum Vitamin A levels have been determined in non-pregnant and pregnant women during short-term or long-term oral contraceptive therapy and the teratological implications of these findings are discussed.

TL;DR: The pattern of disappearance of CAP in the plasma is similar to that of estradiol and progesterone but differs from these hormones in that the half-life of CAP is much longer and the metabolic clearance rate has been found to be 126.6 litres/day indicating a slow clearance of the steroid from the body.

TL;DR: A higher excretion in feces was noted for the progestogen in contrast to the estrogen, which was preferentially excreted in urine, and no significant differences of the metabolic fate were found after chronic treatment with Deladroxate.

TL;DR: These studies provide the first experimental evidence for glycoprotein inhibitors of fertilization, and removal of sialic acid from glycoproteins reduced their antifertility effect.

TL;DR: Investigation of the release rates of 3 H-progesterone contained in two types of polymeric systems when placed in the uterus of rhesus monkeys found no chronic effects of progesterone were noted on the reproductive tracts of the animals.