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Showing papers in "Contraception in 1974"


Journal ArticleDOI
TL;DR: It is concluded that estrogens increase the binding capacity of TeBG, and this is inhibited by norgestrel, and the equilibration dialysis method produced good agreement in accuracy.

226 citations


Journal ArticleDOI
Paul C. Schwallie1, J.R. Assenzo1
TL;DR: Pregnancy rates after discontinuation of Depo-Provera contraception are not different from other methods except for a prolongation of about 8 months and are independent of the number of injections received.

108 citations


Journal ArticleDOI
TL;DR: Alteration of the genital environment and consequent interference with ascent of the sperm might have a role in the contraceptive mechanism of postcoital d -norgestrel.

105 citations


Journal ArticleDOI
K.T. Kirton1, James C. Cornette1
TL;DR: The relationship between peripheral serum concentrations of medroxyprogesterone acetate (Provera) and progesterone following an intramuscular injection of 150 mg of depomedroxyproGEA acetate was determined.

66 citations


Journal ArticleDOI
TL;DR: The affinity and specificity of labelled R 5020 binding to the "7–8S" component have been determined by equilibrium dialysis on total cytosol and were further characterized by crossed competition studies following ammonium sulfate precipitation.

54 citations


Journal ArticleDOI
TL;DR: The plasma half-life of norethindrone was found to be about 3 hours during the first hours after ingestion and about 9 hours thereafter, and a linear correlation was found between ingested dose per kg body weight and plasma peak levels.

54 citations


Journal ArticleDOI
TL;DR: The current state-of-knowledge with respect to methods for the regulation of fertility in the male is presented and areas where future studies may be profitably encouraged are indicated.

50 citations


Journal ArticleDOI
TL;DR: It is concluded that as far as bleeding is concerned with intrauterine devices, Cu-IUDs are more suitable for women, especially in developing countries, than Lippes IUDs.

47 citations


Journal ArticleDOI
TL;DR: It is concluded that there is little reason to encourage couples who are highly motivated towards family planning and who find the condom aesthetically acceptable to change to a more modern method of birth control with its attendant risks unless a very high degree of security is essential.

43 citations


Journal ArticleDOI
TL;DR: It seems that the use-effectiveness of the copper-T-200 is influenced by the insertion technique, and special attention was paid to fundal insertion of the IUD, which may have contributed to the low expulsion and removal rates and the high continuation rate observed.

43 citations


Journal ArticleDOI
TL;DR: The Lippes loop and the Dalkon shield were associated with fluctuating blood loss values whereas blood loss with the TCu 300 was relatively stable at all study periods.

Journal ArticleDOI
TL;DR: Plasma estrogen levels were normal for the follicular phase of the cycle even in amenorrheic patients after 10 to 18 months of use of 5 mg per week of R-2323, and fertility was recovered in less than 6 months in 76 percent of the cases.

Journal ArticleDOI
TL;DR: Insertion of the IUD neither increased the incidence or severity of early complications nor lengthened the stay in hospital after the abortion, according to patients receiving the TCu-200.

Journal ArticleDOI
TL;DR: It was found that the use of the steroid was associated with significant elevations of both glucose and insulin and there was a significant increase in the mean weight during the six months and this was positively correlated with the altered carbohydrate metabolic parameters.

Journal ArticleDOI
TL;DR: It is suggested that sterilization by suprapubic mini-laparotomy, uterine elevation technique, is suitable for a rural set-up, especially in a less developed country.

Journal ArticleDOI
TL;DR: A table presents a list of menses-inducing drugs used for abortions as well as for treating amenorrhea; 71 of the 161 drugs quoted are not now known for causing abortion.

Journal ArticleDOI
TL;DR: Male mice and hamsters were sterilized by 300 mg per kg per day for 14 days, without toxicity, and sterility was apparently mediated by affecting epididymal and vas sperm stores.

Journal ArticleDOI
TL;DR: The result shows that the copper-T device is a good contraceptive alternative, both for parous and nulliparous, and the pregnancy frequency is very low and the continuation rate is well acceptable.

Journal ArticleDOI
TL;DR: It is concluded that the antiimplantation/antifertility action of the compound 67/20 may be due to its inherent estrogenic and antiestrogenic properties.

Journal ArticleDOI
TL;DR: The fibrinolytic activity in the endometrium was studied histochemically in 15 patients before the insertion of a copper intrauterine device and after at least 3 months with the device in situ and it was suggested that this mechanism can be the basis for assessing treatment with inhibitors of fibralelysis, such as epsilonaminocaproic acid and tranexamic acid when menorrhagia caused by an IUD occurs.

Journal ArticleDOI
TL;DR: On resolving the amino compound an excellent separation of activity and acute toxicity was achieved and detailed synthesis will be published elsewhere.

Journal ArticleDOI
TL;DR: This paper represents an updating of a previous manuscript and brings the material up to 90% plus follow-up, still with no pregnancies in patients who met the criteria of the successful treatment plan.

Journal ArticleDOI
TL;DR: The fact that sperm counts in 3 out of 7 males still showed some depression of spermatogenesis at the end of the observation period of 28 weeks after testosterone withdrawal indicate that testosterone enanthate admin istered in the described dose schedule is not a safe male contraceptive agent, and further research on the use of hormones for the control of fertility in men seems warranted.

Journal ArticleDOI
TL;DR: The hypothesis that at least part of the mechanism of action of the progesterone-releasing type of intrauterine devices is due to a direct capacitation inhibiting effect of the uterine secretion is strengthened by the direct demonstration of inhibition of in vitro rabbit spermatozoa capacitation produced by these washings.

Journal ArticleDOI
TL;DR: In this article, the authors performed a study on 10 patients before and during medroxyprogesterone acetate injections for one year and found that baseline plasma cortisol levels were lower after receiving MEDO-PRECIOUS ECTE injections.

Journal ArticleDOI
TL;DR: In this paper, the anti-progesterone (R 2323) was used to prevent conception without ovulation inhibition without using progesterone, and the results showed that R 2323 does not affect return to fertility.

Journal ArticleDOI
TL;DR: The crude saponin preparation from Phytolacca dodecandra and lemmatoxin possessed nearly three times the spermicidal activities of a synthetic detergent currently used as a sPermicidal agent.

Journal ArticleDOI
TL;DR: Copper-T devices used for different periods of time were submitted to metallographic analyses and in vitro sperm penetration tests in order to determine whether there is a time-linked effect.

Journal ArticleDOI
TL;DR: Routine vitamin-B6 administration during hormonal contraception is suggested to reduce the disturbance in tryptophan metabolism and normalization of the excretion is achieved by giving 100 mg vitamin- B6/24hours for 4 weeks.

Journal ArticleDOI
TL;DR: Incubation of copper in a benzene-saturated saline solution yields phenol showing that hydroxyl free radicals are produced, equivalent to that produced by X-rays at a dose rate of 14,000 rads per hour.