Journal•ISSN: 1065-6251
Current Opinion in Hematology
Lippincott Williams & Wilkins
About: Current Opinion in Hematology is an academic journal published by Lippincott Williams & Wilkins. The journal publishes majorly in the area(s): Transplantation & Stem cell. It has an ISSN identifier of 1065-6251. Over the lifetime, 1909 publications have been published receiving 74665 citations.
Topics: Transplantation, Stem cell, Myeloid leukemia, Haematopoiesis, Leukemia
Papers published on a yearly basis
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TL;DR: In vivo infectious models show delayed termination of inflammatory activity and a prolonged fever response in elderly humans, suggesting that the acute phase response is altered in aging, however, a causal relation between the acutephase response and the increased mortality because of bacterial infections in older patients remains to be demonstrated.
Abstract: Aging is associated with increased inflammatory activity reflected by increased circulating levels of TNF-α, IL-6, cytokine antagonists and acute phase proteins in vivo. Epidemiologic studies suggest that chronic low-grade inflammation in aging promotes an atherogenic profile and is related to age-a
640 citations
TL;DR: Mesenchymal stromal cells are a biologically important cell population that are able to support hematopoiesis, are capable of suppressing alloresponses and appear to be nonimmunogenic.
Abstract: Purpose of reviewOur understanding of the biology and properties of mesenchymal stem cells or multipotent mesenchymal stromal cells has expanded dramatically over the last 3 years and is likely to have an impact on clinical practice in the near future, making a review of this topic both timely and r
606 citations
TL;DR: It is shown that mast cells and allergic mechanisms play at least some role in bronchial asthma and the incidence of these mechanisms in a cross section of all asthmatics is high.
Abstract: That mast cells and allergic mechanisms play at least some role in bronchial asthma has been suggested for at least 75 years [92]. The incidence of these mechanisms in a cross section of all asthmatics [31, 77], and the importance of allergic mechanisms as compared with neural mechanisms is controversial, however, and has been discussed and debated for at least as long [16, 113].
506 citations
TL;DR: The importance of SAA in various physiological and pathological processes, including inflammation, atherosclerosis, thrombosis, AA-amyloidosis, rheumatoid arthritis, and neoplasia, is emphasized and new functions, affecting cell adhesion, migration, proliferation and aggregation are described.
Abstract: Serum amyloid A (SAA), the precursor protein in inflammation-associated reactive amyloidosis (AA-type), is an acute phase reactant whose level in the blood increases in response to various insults. It is expressed in the liver, but its physiological role is not well understood. Recently, a broader view of SAA expression and function has been emerging. Expression studies show local production of SAA proteins in histologically normal, atherosclerotic, Alzheimer, inflammatory, and tumor tissues. Binding sites in the SAA protein for high density lipoproteins, calcium, laminin, and heparin/heparan-sulfate were described. Adhesion motifs were identified and new functions, affecting cell adhesion, migration, proliferation and aggregation have been described. These findings emphasize the importance of SAA in various physiological and pathological processes, including inflammation, atherosclerosis, thrombosis, AA-amyloidosis, rheumatoid arthritis, and neoplasia. In addition, recent experiments suggest that SAA may play a "housekeeping" role in normal human tissues.
430 citations
TL;DR: Evidence that demonstrates an active role for red cells in normal and pathologic hemostasis is summarized and the possible molecular mechanisms whereby a usually inert erythrocyte can actively contribute to the processes of clot formation are evaluated.
Abstract: Most biomedical textbooks teach that coagulation and thrombosis are primarily a function of endothelial cells, platelets, and soluble coagulation factors. Red blood cells, in contrast, are generally regarded as innocent bystanders, passively entrapped in a developing thrombus as they flow through the vasculature. This review summarizes evidence that demonstrates an active role for red cells in normal and pathologic hemostasis. We then evaluate the possible molecular mechanisms whereby a usually inert erythrocyte can actively contribute to the processes of clot formation.
354 citations