Showing papers in "Current Pharmacology Reports in 2022"
TL;DR: The role of myricetin and its role in combating many diseases was reviewed in this paper , where the role of free radicals and their effects on different metabolic pathways was discussed.
Abstract: The root cause of many diseases like CVD, cancer, and aging is free radicals which exert their effect by interfering with different metabolic pathways. The sources of free radicals can be exogenous, like UV rays from sunlight, and endogenous due to different metabolic by-products.In our body, there are defense mechanisms present, such as antioxidant enzymes and antioxidant molecules to combat these free radicals, but if there is an overload of these free radicals in our body, the defense system may not be sufficient to neutralize these free radicals. In such situations, we are exposed to a chronic low dose of oxidants creating oxidative stress, which is responsible for eliciting different diseases.Pubmed and Google Scholar are the search engines used to sort out relevant papers on myricetin and its role in combating many diseases. Myricetin is present in many fruits and vegetables and is a known antioxidant. It can elevate the antioxidant enzyme levels; reduces the lipid peroxidation; and is known to protect against cancer. In the case of myocardial dysfunction, myricetin has been shown to suppress the inflammatory cytokines and reduced the mortality rate. Myricetin has also been found to reduce platelet aggregation and control the viral infections by interfering in the DNA replication pathways.In this paper, we have briefly reviewed about the different type and site of free radicals and the role of myricetin in addressing the ROS and different diseases.
24 citations
TL;DR: The role of myricetin and its role in combating many diseases was reviewed in this paper , where the role of free radicals and their effects on different metabolic pathways was discussed.
Abstract: The root cause of many diseases like CVD, cancer, and aging is free radicals which exert their effect by interfering with different metabolic pathways. The sources of free radicals can be exogenous, like UV rays from sunlight, and endogenous due to different metabolic by-products.In our body, there are defense mechanisms present, such as antioxidant enzymes and antioxidant molecules to combat these free radicals, but if there is an overload of these free radicals in our body, the defense system may not be sufficient to neutralize these free radicals. In such situations, we are exposed to a chronic low dose of oxidants creating oxidative stress, which is responsible for eliciting different diseases.Pubmed and Google Scholar are the search engines used to sort out relevant papers on myricetin and its role in combating many diseases. Myricetin is present in many fruits and vegetables and is a known antioxidant. It can elevate the antioxidant enzyme levels; reduces the lipid peroxidation; and is known to protect against cancer. In the case of myocardial dysfunction, myricetin has been shown to suppress the inflammatory cytokines and reduced the mortality rate. Myricetin has also been found to reduce platelet aggregation and control the viral infections by interfering in the DNA replication pathways.In this paper, we have briefly reviewed about the different type and site of free radicals and the role of myricetin in addressing the ROS and different diseases.
21 citations
TL;DR: A review of the recent literature related to the FDA-approved drugs that had been repurposed as potential drug candidates against COVID-19 is provided in this article , where a quality pharmacophore study for frequently studied targets, namely, the main protease, RNA-dependent RNA polymerase, and spike protein are performed.
Abstract: This article provides a review of the recent literature related to the FDA-approved drugs that had been repurposed as potential drug candidates against COVID-19. Moreover, we performed a quality pharmacophore study for frequently studied targets, namely, the main protease, RNA-dependent RNA polymerase, and spike protein.Ever since the COVID-19 pandemic, the whole spectrum of scientific community is still unable to invent an absolute therapeutic agent for COVID-19. Considering such a fact, drug repurposing strategies seem a truly viable approach to develop novel therapeutic interventions.Drug repurposing explores previously approved drugs of known safety and pharmacokinetics profile for possible new effects, reducing the cost, time, and predicting prospective side effects and drug interactions. COVID-19 virulent machinery appeared similar to other viruses, making antiviral agents widely repurposed in pursuit for curative candidates. Our main protease pharmacophoric study revealed multiple features and could be a probable starting point for upcoming research.
15 citations
TL;DR: In this paper , the binding affinity of methylxanthines with SARS-CoV-2 target proteins was determined using Autodock Vina, and the best interacting complexes were performed using GROMACS 2018.
Abstract: The aim of the present study was to test the binding affinity of methylxanthines (caffeine/theine, methylxanthine, theobromine, theophylline and xanthine) to three potential target proteins namely Spike protein (6LZG), main protease (6LU7) and nucleocapsid protein N-terminal RNA binding domain (6M3M) of SARS-CoV-2. Proteins and ligand were generated using AutoDock 1.5.6 software. Binding affinity of methylxanthines with SARS-CoV-2 target proteins was determined using Autodock Vina. MD simulation of the best interacting complexes was performed using GROMACS 2018.3 (in duplicate) and Desmond program version 2.0 (academic version) (in triplicate) to study the stabile interaction of protein-ligand complexes. Among the selected methylxanthines, theophylline showed the best binding affinity with all the three targets of SARS-CoV-2 (6LZG - 5.7 kcal mol-1, 6LU7 - 6.5 kcal mol-1, 6M3M - 5.8 kcal mol-1). MD simulation results of 100 ns (in triplicate) showed that theophylline is stable in the binding pockets of all the selected SARS-CoV-2 proteins. Moreover, methylxanthines are safer and less toxic as shown by high LD50 value with Protox II software as compared to drug chloroquine. This research supports the use of methylxanthines as a SARS-CoV-2 inhibitor. It also lays the groundwork for future studies and could aid in the development of a treatment for SARS-CoV-2 and related viral infections.The online version contains supplementary material available at 10.1007/s40495-021-00276-3.
9 citations
TL;DR: In this paper , the binding affinity of methylxanthines with SARS-CoV-2 target proteins was determined using Autodock Vina, and the best interacting complexes were performed using GROMACS 2018.
Abstract: The aim of the present study was to test the binding affinity of methylxanthines (caffeine/theine, methylxanthine, theobromine, theophylline and xanthine) to three potential target proteins namely Spike protein (6LZG), main protease (6LU7) and nucleocapsid protein N-terminal RNA binding domain (6M3M) of SARS-CoV-2. Proteins and ligand were generated using AutoDock 1.5.6 software. Binding affinity of methylxanthines with SARS-CoV-2 target proteins was determined using Autodock Vina. MD simulation of the best interacting complexes was performed using GROMACS 2018.3 (in duplicate) and Desmond program version 2.0 (academic version) (in triplicate) to study the stabile interaction of protein-ligand complexes. Among the selected methylxanthines, theophylline showed the best binding affinity with all the three targets of SARS-CoV-2 (6LZG - 5.7 kcal mol-1, 6LU7 - 6.5 kcal mol-1, 6M3M - 5.8 kcal mol-1). MD simulation results of 100 ns (in triplicate) showed that theophylline is stable in the binding pockets of all the selected SARS-CoV-2 proteins. Moreover, methylxanthines are safer and less toxic as shown by high LD50 value with Protox II software as compared to drug chloroquine. This research supports the use of methylxanthines as a SARS-CoV-2 inhibitor. It also lays the groundwork for future studies and could aid in the development of a treatment for SARS-CoV-2 and related viral infections.The online version contains supplementary material available at 10.1007/s40495-021-00276-3.
9 citations
TL;DR: In this paper , the morphology, occurrence, and distribution of Moringa sp., chemical constitutions of moringa leaves, its potential as anticancer, antidiabetes, and antimicrobial agent and as a nutritional supplement and the commercial future of various products.
Abstract: Worldwide occurring Moringa plant is commonly famous as a fruit vegetable, known as drumstick or shevga all over India. The miraculous nutritional potential of the drumstick plant was already proved by worldwide research. But in the common population, it is unknown for the nutritional potential of its leaves. The majority of the population is known it only as a fruit vegetable. The Moringa leaves contain almost all essential nutrients, growth factors, vitamins, amino acids, proteins, minerals, and metals like potassium, iron, and zinc. Besides these, nowadays, plant leaves may be used to prepare various nutritional supplements and medicine.Besides this, this review takes into account some joint efforts of NASI, Allahabad-funded project to use these Moringa leaves for different formulations and its popularization efforts for malnutrition eradication in tribal, i.e., development of recipes of Moringa leaves that will not only make easy preparations but also help to make habitual use of Moringa leaves today.This review describes the morphology, occurrence, and distribution of Moringa sp., chemical constitutions of Moringa leaves, its potential as anticancer, antidiabetes, and antimicrobial agent and as a nutritional supplement and the commercial future of various products.
8 citations
TL;DR: This review will summarize CoQ10’s background, biochemistry, pharmacokinetics and bioavailability, physicochemical properties, mechanism of action, valuable functions, consequences of deprivation and overconsumption, available marketed formulations, and the impact of CoQ 10 therapy in various neurodegenerative diseases based on preclinical and clinical research.
5 citations
5 citations
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4 citations
TL;DR: The collected pharmacological evidence suggests that all the plant ingredients of Ashtanga Ghrita have neuroprotective, anxiolytic, antidepressant, antioxidant, immunomodulatory, sedative, antiproliferative and anticonvulsant activity.
TL;DR: In this paper , the authors highlight the pre-existing treatment options and specific purposes to shed some light upon the development of a new drug lefamulin and its specifications and explore this novel drug's superior efficacy to already existing treatment strategies.
Abstract: Community-acquired bacterial pneumonia (CABP) continues to be a worldwide health concern since it is the major cause of mortality and hospitalisation worldwide. Increased macrolide resistance among Streptococcus pneumoniae and other infections has resulted in a significantly larger illness burden, which has been exacerbated by evolving demography and a higher prevalence of comorbid disorders. Owing to such circumstances, the creation of new antibiotic classes is critical. Lefamulin, also referred to as BC-3781, is the primary pleuromutilin antibiotic which has been permitted for both intravenous and oral use in humans for the remedy of bacterial infections. It has shown activity against gram-positive bacteria including methicillin-resistant strains as well as atypical organisms which as often implicated in CABP. It has a completely unique mechanism of action that inhibits protein synthesis via way of means of stopping the binding of tRNA for peptide transfer. The C(14) side chain is responsible for its pharmacodynamic and antimicrobial properties, together with supporting in overcoming bacterial ribosomal resistance and mutations improvement amplifying the number of hydrogen bonds to the target site. This review aims to highlight the pre-existing treatment options and specific purposes to shed some light upon the development of a new drug lefamulin and its specifications and explore this novel drug’s superior efficacy to already existing treatment strategies.
TL;DR: In this article , a review sheds a bright light towards several mechanisms at both cellular and molecular level, correlation of NP-mediated disease mechanism and possible cell surface biomarkers (receptors), and identified genes could be more promising for their pharmacological targets.
Abstract: Neuropathic pain (NP) has been ubiquitously characterized by lesion and its linked somatosensory system either the central nervous system (CNS) or peripheral nervous system (PNS) This PNS episode is the most prevalent site of NP origin and is found to be associated with afferent nerve fibers carrying pain signals from injured/trauma site to the CNS including the brain. Several kinds of pharmacotherapeutic drugs shuch as analgesics, anti-convulsants, and anti-depressants are being employed for the its possible interventions. The NP has been a great interest to follow different pathophysiological mechanisms which are often considered to correlate with the metabolic pathways and its mediated disease. There is paucity of knowledge to make such mechanism via NP.Most notably, recent pandemic outbreak of COVID-19 has also been reported in chronic pain mediated diabetes, inflammatory disorders, and cancers. There is an increasing incidence of NP and its complex mechanism has now led to identify the possible investigations of responsible genes and proteins via bioinformatics tools. The analysis might be more instrumental as collecting the genes from pain genetic database, analyzing the variants through differential gene expression (DEG) and constructing the protein-protein interaction (PPI) networks and thereby determining their upregulating and downregulating pathways.This review sheds a bright light towards several mechanisms at both cellular and molecular level, correlation of NP-mediated disease mechanism and possible cell surface biomarkers (receptors), and identified genes could be more promising for their pharmacological targets.
TL;DR: The present paper reviews the recent information on the potential therapy of normal and diabetic wounds through treatment with phenolic compounds with the combination of polymer-based biomaterial that plays an essential role in the healing process.
TL;DR: It is utmost necessary to understand the mechanisms by which the cytokines contribute to pathophysiology of psoriasis and its translational benefits to the medical practice.
TL;DR: In this paper , the role of malnutrition in people living with HIV in the context of COVID-19 and emphasis the need of supplementation, dietary intervention, and nutritional counselling in the post-COVID era.
Abstract: This review elaborates the role of malnutrition in PLHIV (people living with HIV) in the context of COVID-19 and emphasis the need of supplementation, dietary intervention, and nutritional counselling in the post-COVID era. One of the most critical challenges among HIV/AIDS patients is malnutrition since it weakens the immune system and increases risk to opportunistic infections. In HIV (human immunodeficiency virus) infection, weight loss is prevalent due to reduced nutritional consumption, malabsorption, abnormal metabolism, and antiretroviral therapy. Sufficient nutrition is required for optimal immune function, as a result, food therapy is now considered an important adjuvant in the treatment of HIV patients. Nutritional intervention, such as the use of dietary supplements, can help to prevent nutrient deficiency, lowering the death risk among malnourished HIV population. Immunocompromised individuals are at very high risk for COVID-19 and malnutrition increases the risk of infection by multiple folds. Interventions, such as nutrition education and counselling are important, to improve the condition of HIV Patients by optimising their nutritional status. A balanced diet should be one of the most important priorities in preventing PLHIV against the potentially deadly consequences of COVID-19. It is to be ensured that HIV-positive persons continue to get enough and appropriate assistance, such as nutrition and psychological counselling, in the context of COVID-19 infection. The use of telemedicine to maintain nutritional intervention can be beneficial. To meet their nutritional needs and minimise future difficulties, PLHIV infected with COVID-19 should get specialised nutritional education and counselling.
TL;DR: In this paper , the authors provided an explanatory manuscript regarding the SARS-Corona virus 2. Sub-titled as the history of single-stranded RNA, internal characters of COVID-19, resource, the life cycle of co-evolved COVID19, reservoir of the disease, secondary infections of CO VID-19 and nano herbal remedy, they showed that curcumin-mediated synthesized AgNPs show its potential character in the entry of respiratory syncytial virus (RSV), blocks interaction with the viral surface, and damages the viral protein.
Abstract: This article provides the explanatory manuscript regarding the SARS-Corona virus 2. Sub-titled as the history of single-stranded RNA, internal characters of COVID-19, resource, the life cycle of COVID-19, reservoir of the disease, secondary infections of COVID-19 and nano herbal remedy. The skin is not the main target of the SARS-corona virus 2 infections but somehow directly or indirectly, it causes exacerbating eruptions on the skin. Recent research shows that curcumin–mediated synthesized AgNPs show its potential character in the entry of respiratory syncytial virus (RSV), blocks interaction with the viral surface, and damages the viral protein. In modern days, molecular docking studies fabricated copper iodide flower extract (CuI-FE) which shows tough inhibitory action against COVID-19. Many articles show green synthesis–mediated nanoparticles like silver, gold, zinc, copper, iron, titanium dioxide, selenium, and cadmium which possess high anti-viricidal activity. The anti-oxidant, anti-viral, anti-inflammatory, anti-hive rich plant–mediated nanoparticle synthesis might be an alternative betterment, cost-effective, and eco-friendly medication for the skin disease caused by SARS-corona virus 2 (the viral clinical signs are itchy, hives, rashes, papules, psoriasis, and inflammation) and (non-viral clinical signs-pressure urticaria, contact dermatitis, and acne) that occurred as the result of COVID-19.
TL;DR: The marine natural products (MNPs) have demonstrated a wide range of pharmacological properties including antibacterial, antiviral, analgesic, anticancer, apoptotic, angiogenic, and antioxidant properties.