Journal•ISSN: 1356-1049
European Journal of Mass Spectrometry
SAGE Publishing
About: European Journal of Mass Spectrometry is an academic journal. The journal publishes majorly in the area(s): Mass spectrometry & Electrospray ionization. It has an ISSN identifier of 1356-1049. Over the lifetime, 1661 publications have been published receiving 16215 citations.
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TL;DR: This method of calibrating a commercially available electrospray ionisation (ESI)-travelling wave ion mobility spectrometry (TWIMS)–mass spectrometer using known cross-sectional areas determined for a range of biomolecules by conventional IMS-MS suggests that the gas phase ESI- TWIMS-MS measurements relate well to solution-based measurements derived from other biophysical techniques.
Abstract: Detailed knowledge of the tertiary and quaternary structure of proteins and protein complexes is of immense importance in understanding their functionality. Similarly, variations in the conformational states of proteins form the underlying mechanisms behind many biomolecular processes, numerous of which are disease-related. Thus, the availability of reliable and accurate biophysical techniques that can provide detailed information concerning these issues is of paramount importance. Ion mobility spectrometry (IMS) coupled to mass spectrometry (MS) offers a unique opportunity to separate multi-component biomolecular entities and to measure the molecular mass and collision cross-section of individual components in a single, rapid (
329 citations
TL;DR: An overview of electron capture dissociation can be found in this article, where current views on the ECD mechanism are discussed using both published and new examples, as well as the history of ECD discovery and development.
Abstract: Electron-capture dissociation (ECD) is a new fragmentation technique that utilizes ion–electron recombination reactions. The latter have parallels in other research fields; revealing these parallels helps to understand the ECD mechanism. An overview is given of ECD-related phenomena and of the history of ECD discovery and development. Current views on the ECD mechanism are discussed using both published and new examples.
242 citations
TL;DR: Advances in silylation as a powerful tool used for increasing the volatility, thermal and thermo-catalytic stability, and chromatographic mobility of polar and unstable organic compounds are described.
Abstract: This is the first of a series of reviews on the application of derivatization in mass spectrometry. A description is given of advances in silylation as a powerful tool used for increasing the volatility, thermal and thermo-catalytic stability, and chromatographic mobility of polar and unstable organic compounds. In addition to chemical aspects of silylation, mass spectral properties of silyl derivatives useful for structure determination and quantitation of various organic and biologically-active compounds, mainly by GC/MS, are described. Practically all tested and widely used silylating agents are described. The role of comprehensive libraries containing reference mass spectra for various silyl derivatives and search systems in structure determination is emphasized. Applications of silylation for particular analyses are summarised.
213 citations
TL;DR: It is shown that the intrinsic reactivity of each key gaseous species fished by ESI can be further investigated via ESI-tandem mass spectrometry experiments, searching for the most active species via gas-phase ion/molecule reactions.
Abstract: Electrospray ionization mass spectrometry (ESI-MS), in conjunction with its tandem version ESI-MS/MS, is now established as a major tool to study reaction mechanisms in solution. This suitability results mainly from the ability of ESI to "fish" ions directly from solution to the gas phase environment of mass spectrometers. In this review, we summarize recent studies from our laboratory on the use of on-line monitoring by ESI-MS ion fishing of several types of reactions that permitted us to follow how these reactions progress as a function of both time and conditions using the ultra-high sensitivity and speed of ESI-MS to detect and even characterize transient reaction intermediates. We also show that the intrinsic reactivity of each key gaseous species fished by ESI can be further investigated via ESI-tandem mass spectrometry experiments, searching for the most active species via gas-phase ion/molecule reactions. In the gas-phase, solvent and counter-ion effects are absent. These studies often permit a detailed overview of major steps via the interception, characterization and reactivity investigation of key reaction players.
178 citations
TL;DR: A novel computational and visual approach for the analysis of high-field Fourier transform ion cyclotron resonance mass spectra (FT-ICR-MS) based on successive and multiple atomic and Kendrick analogous mass difference analyses is proposed.
Abstract: We propose a novel computational and visual approach for the analysis of high-field Fourier transform ion cyclotron resonance mass spectra (FT-ICR-MS) based on successive and multiple atomic and Kendrick analogous mass difference analyses. Compositional networks based on elemental compositions and functional networks based on selected functional group equivalents enable improved assignment options of elemental composition and classification of organic complexity with tuneable validation windows. The approach is demonstrated through the analysis of a 12 T FT-ICR mass spectrum of an intricate water-soluble extract of a secondary organic aerosol with a previously established abundance in CHNOS molecules.
162 citations