Journal•ISSN: 1120-6721
European Journal of Ophthalmology
SAGE Publishing
About: European Journal of Ophthalmology is an academic journal published by SAGE Publishing. The journal publishes majorly in the area(s): Medicine & Visual acuity. It has an ISSN identifier of 1120-6721. Over the lifetime, 5544 publications have been published receiving 63548 citations.
Topics: Medicine, Visual acuity, Glaucoma, Intraocular pressure, Vitrectomy
Papers published on a yearly basis
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TL;DR: Compared to preservedeyedrops, preservative free eyedrops are significantly less associated with ocular symptoms and signs of irritation.
Abstract: Purpose.To compare the prevalence of side effects between eyedrops with or without preservatives, in terms of subjective symptoms and objective signs in patients with open-angle glaucoma.Methods.In...
370 citations
TL;DR: The blood-retinal barrier (BRB) as discussed by the authors is a physiologic barrier that regulates ion, protein, and water flux into and out of the retina and plays a crucial role in the development of retinal diseases.
Abstract: The blood-ocular barrier system is formed by 2 main barriers: the blood-aqueous barrier and the blood-retinal barrier (BRB). The BRB is particularly tight and restrictive and is a physiologic barrier that regulates ion, protein, and water flux into and out of the retina. The BRB consists of inner and outer components, the inner BRB being formed of tight junctions between retinal capillary endothelial cells and the outer BRB of tight junctions between retinal pigment epithelial cells. The BRB is essential to maintaining the eye as a privileged site and is essential for normal visual function. Methods of clinical evaluation of the BRB are reviewed and new directions using optical coherence tomography are presented. Alterations of the BRB play a crucial role in the development of retinal diseases. The 2 most frequent and relevant retinal diseases, diabetic retinopathy and age-related macular degeneration (AMD), are directly associated with alterations of the BRB. Diabetic retinopathy is initiated by an alteration of the inner BRB and neovascular AMD is a result of an alteration of the outer BRB. Macular edema is a direct result of alterations of the BRB.
344 citations
TL;DR: Worldwide epidemiologic studies may help the clinician in the management of patients with inflammatory ocular diseases, enabling the comparison of different uveitis entities.
Abstract: PurposeWe describe the worldwide epidemiology of uveitis through a systematic literature review.MethodsData obtained from the most relevant studies published until November 2012 were reported.Resul...
227 citations
TL;DR: Subretinal human RPE allografts present a high rejection rate (75%) without immunosuppression, however, small extrafoveal transplants remained unchanged in shape, size and color for more than two years in non-exudative AMD.
Abstract: PurposeTo determine the long-term outcome of human retinal pigment epithelium (RPE) transplants in patients with advanced age-related macular degeneration (AMD).MethodsUsing pars plana microsurgica...
205 citations
TL;DR: Average retinal thickness and mean local variations in a normal population were defined using a commercially available mapping software and OCT seems a sensitive tool for detecting early retinal thickening in diabetic patients.
Abstract: PURPOSE. To define the normal retinal thickness in healthy subjects using optical coherence tomography (OCT) mapping software and to assess the ability of OCT to detect early macular thickening in diabetic patients. METHODS. Six radial scans centered on the fixation point were done on 60 healthy eyes and 70 eyes of 35 diabetic patients without macular edema on biomicroscopy. Retinal thickness was measured automatically with OCT mapping software. Mean retinal thickness was compared in subgroups of healthy patients based on age, sex, and eye, and in the eyes of diabetic patients and healthy subjects. Thickening was diagnosed if mean retinal thickness of an area was greater than the mean thickness + 2SD in the corresponding area in healthy subjects; or if the difference between right and left eye exceeded the mean difference + 2 SD in a given area in healthy subjects. RESULTS. In healthy subjects, mean retinal thickness in the central macular area 1000 µm in diameter was 170±18 µm. There was no significant difference according to age, or left or right eye, but central macular thickness was significantly greater in men than women (p=0.0139). No difference was observed between the eyes of healthy subjects and diabetic patients without macular edema on biomicroscopy , but OCT detected early macular thickening in 12 diabetic eyes. CONCLUSIONS. In this study average retinal thickness and mean local variations in a normal population were defined using a commercially available mapping software. OCT seems a sensitive tool for detecting early retinal thickening. (Eur J Ophthalmol 2002; 12: 102-8)
177 citations