Showing papers in "FEBS Letters in 2022"

TL;DR: In this article , a review explores the bioenergetic hypothesis for the neurodegenerative pathomechanisms, discussing factors leading to age-related brain hypometabolism and its contribution to cognitive decline.

TL;DR: In all vertebrates including mammals, the ergothioneine transporter ETT (obsolete name OCTN1; human gene symbol SLC22A4) is a powerful and highly specific transporter for the uptake of ET as discussed by the authors .

TL;DR: The lipid A portion of LPS is mutable and comprises the main virulence and endotoxic component, thus contributing to the structural and functional diversity among LPSs from microbial species.

TL;DR: The emerging role of exosomes as new important vehicles for physiological systemic crosstalk failures, which could lead to organ dysfunction during neuroinflammation or aging, is highlighted.

TL;DR: It is found that the degree of unsaturation of fatty acids in PS alters the rate of insulin aggregation, and toxicity of insulin–DMPS aggregates is significantly lower than the toxicity of DOPS– and POPS–insulin fibrils, whereas all these lipid‐containing aggregates exert lower cell toxicity than insulin fibril grown in a lipid‐free environment.

TL;DR: Ergothioneine (ERGO) is a potent antioxidant and anti-inflammatory amino acid that is highly bioavailable to humans from the diet as discussed by the authors , but only limited knowledge exists regarding ERGO content in the human diet.

TL;DR: A brief review will highlight new findings related to LRRK2-mediated phosphorylation of Rab GTPases and its consequences and flips a switch on Rab effector selection with dominant consequences for cell pathophysiology.

TL;DR: Using these opposing dementia markers, not only diagnosis, but also therapeutic interventions to mitigate cognitive decline may now become possible.

TL;DR: This review focuses on the roles of autophagy in plant virus infection and offers a glimpse of recent advances about how plant viruses evade Autophagy or manipulate host autophagic pathways to complete their replication cycle.

TL;DR: The technology of CAR‐Ts is explained, focusing on the composition of CARs, their application, and limitations in cancer therapy, as well as on the current strategies to overcome the challenges encountered.

TL;DR: The SIRT3–MLKL interaction may mediate the necroptotic effects of Egt in CRC, suggesting the potential of this dietary amino thione in the prevention of CRC.

TL;DR: It is discovered that the C‐terminal region modulates α‐synuclein phase separation through electrostatic interactions and pave the path for understanding the mechanism of truncated α‐Syn in PD pathology.

TL;DR: In vitro observations suggest that ERGO benefits brain function through both its antioxidative activity and by promoting neurogenesis and neuronal maturation.

TL;DR: The authors found that TGFβ1/Smad signalling is more activated in high versus low grade Renal Cell Carcinoma (ccRCC) and inversely correlates with Abl2 tyrosine kinase protein expression.

TL;DR: A conservative overview of software that scientists use in daily routine is provided and insights into emerging new tools are given.

TL;DR: In this article , a review of how different modes of chemical reactivity account for the reported molecular biological activities of l-ergothioneine is provided, and a new perspective of the function and the mode of action of this enigmatic molecule emerges.

TL;DR: The effects of autophagy inhibitors on LAP are dissected to target LAP with small molecule inhibitors given its emerging role in infectious and autoimmune diseases.

TL;DR: The presence of a specific transporter together with the avid retention of ET in the body implies that this compound is important to us, and indeed in 2018 Bruce Ames proposed that ET be classified as a ‘longevity vitamin’.

TL;DR: The dualistic role of autophagy in plant immunity emphasizes that much remains to be explored in this area.

TL;DR: Different pathogenicity drivers by which MYBPC3 variants can cause disease are examined, focussing on protein haploinsufficiency as a common pathomechanism also in nontruncating variants.

TL;DR: The field of Bioinorganic Supramolecular Chemistry is an emerging research area including metal-based supramolecules resulting from coordination-driven self-assembly (CDSA), whereby metal ions and organic ligands can be easily linked by metal-ligand bonds via Lewis' acid/base interactions as mentioned in this paper .

TL;DR: The mechanisms underlying the recognition and sorting of proteins at endosomes, membrane remodeling and budding, and their implications for cellular trafficking and physiological responses in plants are discussed.

TL;DR: How the engineering of fluorescent proteins and the development of super‐resolution fluorescence microscopy have significantly renewed the interest in CLEM resulting in the present application of fluorescence CLEM in many different areas of cellular and molecular biology is described.

TL;DR: This review focuses on the molecular mechanisms identified thus far that contribute to slow biochemical processes underlying the measurement of time on a 24-hour scale in the circadian clocks of the cyanobacterium Synechococcus elongatus, the filamentous fungus Neurospora crassa, and the metazoans Drosophila melanogaster, Mus musculus and humans.

TL;DR: A novel exosome‐mediated mechanism of microglial cell–Aβ crosstalk that facilitates Aβ clearance under either physiological or pathological conditions in the central nervous system is delineated.

TL;DR: This review summarizes the major stages in cytokinesis, endomembrane components involved in cell plate assembly and its transition to a new cell wall.

TL;DR: In this paper , the authors discuss the versatile function of long noncoding RNAs involved in the metabolic regulation of glucose and lipid, and mitochondrial function, and how the dysregulation of lncRNAs induces the development of various metabolic disorders and their cardiovascular consequences.

TL;DR: This review introduces glycans as cell‐identification structures, discussing how glycans modulate host–pathogen interactions and how they can fine‐tune inflammatory processes associated with infection, inflammation and autoimmunity.

TL;DR: Structural studies revealed how a conserved nucleotide sensor in DOCKDHR2 catalyses nucleotide exchange, the basis for how different DOCK proteins activate specifically CDC42 and RAC1, and sometimes both, and how up-stream regulators relieve the ELMO-mediated auto-inhibition.

TL;DR: The importance of membrane homeostasis, either at the plasma membrane (PM) or between PM‐targeted trafficking and vacuolar trafficking, for pollen tube growth is discussed, and current findings on endomembrane compartments and vesicular trafficking routes of pollen tubes are summarized.