R
Reinier A. Boon
Researcher at Goethe University Frankfurt
Publications - 120
Citations - 9526
Reinier A. Boon is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Endothelial stem cell & Angiogenesis. The author has an hindex of 38, co-authored 95 publications receiving 7762 citations. Previous affiliations of Reinier A. Boon include University of Amsterdam & Vanderbilt University Medical Center.
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Journal ArticleDOI
Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs.
Eduard Hergenreider,Susanne Heydt,Karine Tréguer,Thomas Boettger,Anton J.G. Horrevoets,Andreas M. Zeiher,Margot P. Scheffer,Achilleas S. Frangakis,Xiaoke Yin,Manuel Mayr,Thomas Braun,Carmen Urbich,Reinier A. Boon,Stefanie Dimmeler +13 more
TL;DR: The results show that atheroprotective stimuli induce communication between endothelial cells and SMCs through an miRNA- and extracellular-vesicle-mediated mechanism and that this may comprise a promising strategy to combat atherosclerosis.
Journal ArticleDOI
Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth
Katharina M. Michalik,Xintian You,Yosif Manavski,Anuradha Doddaballapur,Martin Zörnig,Thomas Braun,David John,Yuliya Ponomareva,Wei Chen,Shizuka Uchida,Reinier A. Boon,Stefanie Dimmeler +11 more
TL;DR: Silencing of MALAT1 tips the balance from a proliferative to a migratory endothelial cell phenotype in vitro, and its genetic deletion or pharmacological inhibition reduces vascular growth in vivo.
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MicroRNA-34a regulates cardiac ageing and function
Reinier A. Boon,Kazuma Iekushi,Stefanie Lechner,Timon Seeger,Ariane Fischer,Susanne Heydt,David Kaluza,Karine Tréguer,Guillaume Carmona,Angelika Bonauer,Anton J.G. Horrevoets,Nathalie Didier,Zenawit Girmatsion,Peter Biliczki,Joachim R. Ehrlich,Hugo A. Katus,Oliver Müller,Michael Potente,Michael Potente,Andreas M. Zeiher,Heiko Hermeking,Stefanie Dimmeler +21 more
TL;DR: Age-induced expression of miR-34a and inhibition of its target PNUTS is identified as a key mechanism that regulates cardiac contractile function during ageing and after acute myocardial infarction, by inducing DNA damage responses and telomere attrition.
Journal ArticleDOI
Long Noncoding RNAs: From Clinical Genetics to Therapeutic Targets?
TL;DR: The authors summarize the current understanding of lncRNA functions and their role as biomarkers in cardiovascular diseases.
Journal ArticleDOI
Proteomic Analysis of the Arabidopsis Nucleolus Suggests Novel Nucleolar Functions
Alison F. Pendle,Gillian P. Clark,Reinier A. Boon,Dominika Lewandowska,Yun Wah Lam,Jens S. Andersen,Matthias Mann,Angus I. Lamond,John W. S. Brown,Peter Shaw +9 more
TL;DR: The first proteomic analysis of plant (Arabidopsis thaliana) nucleoli is described, in which 217 proteins are identified, allowing a direct comparison of the proteomes of an important nuclear structure between two widely divergent species: human and Arabidopsis.