Showing papers in "Frontiers in Neuroendocrinology in 2023"

TL;DR: In this paper , the effects of progesterone and synthetic progestins on neurogenesis, synaptogenesis, myelination and six neurotransmitter systems were systematically summarized with a focus on randomized placebo-controlled trials and cross-sectional studies controlling for progestin type.

TL;DR: A review of the main preclinical and human studies involving the orexin system with several psychiatric and neurodegenerative diseases is presented in this paper , which constitutes a nice example of how basic scientific research driven by curiosity can be the best route to the generation of new and powerful pharmacological treatments.

TL;DR: In this article , a comprehensive review of both clinical and preclinical studies that investigated loneliness and social isolation as risk factors for Alzheimer's disease was presented, and the authors discussed that understanding the mechanisms of how loneliness exacerbates cognitive impairment and AD with a focus on sex differences will shed the light for the underlying mechanisms regarding loneliness as a risk factor for AD and to develop effective prevention or treatment strategies.

TL;DR: The authors surveyed the literature on hormonal contraception and cognition to determine whether studies considered HC formulation, phase, pharmacokinetics, duration, and gene interactions, and assessed whether oversight of these factors might contribute to variable findings.

TL;DR: In this article , the authors consider the evidence for all sides and present an alternative explanation: neurochemical identity, including classical neurotransmitter content, is subject to change, and posit that MCH neurons may release GABA and/or glutamate at different points according to environmental and contextual factors.

TL;DR: In this article , a review of clinical and preclinical studies investigating how cycling ovarian hormones affect nicotine-, cocaine-, and opioid-related behaviors is presented, highlighting the critical need to study women-specific factors that may influence aspects of substance use disorders.

TL;DR: In this article , Gut-microbial homeostasis appears to modulate several key pathways relevant to a variety of psychiatric, metabolic, and inflammatory disorders, including immune, endocrine, endocannabinoid, and kynurenine pathways.

TL;DR: In this article , the authors systematically and quantitatively review evidence derived from both postmortem brain and PET studies to explore the pathological role of glia induced neuroinflammation in the pathogenesis of ASD, and discuss the implications of these findings in relation to disease pathogenesis and therapeutic strategies.

TL;DR: In this paper , the authors examine variation in the neuroendocrine mechanisms that coregulate social behavior and signal production and perception in weakly electric fishes, which are likely targets of selection during social evolution.

TL;DR: In this article , the authors discuss the prevalence of cannabis use and CUD in women throughout their lifespan and provide a balanced prospective on the positive and negative consequences of using cannabis use, highlighting the necessity for continued research that goes beyond sex differences.

TL;DR: In this article , the effects of ectopic fat on brain structure and cognitive function via systemic review and meta-analysis were investigated via a total of 22 studies, encompassing 1,003,593 participants.

TL;DR: The rapid and continual development of a number of radiopharmaceuticals targeting different receptor, enzyme and small molecule systems has fostered Positron Emission Tomography (PET) imaging of endocrine system actions in vivo in the human brain for several decades as discussed by the authors .

TL;DR: The impact of alcohol use disorder on neurobiobehavioral outcomes, including its impact on social cognition/emotion processing, and its acute effects in older women was explored in this article .

TL;DR: In this article , the authors proposed mechanisms by which cardiometabolic disease may alter estrogen effects, including both alterations in actions directly on brain memory systems and actions on cardiometric systems, which in turn impact brain memory system.

TL;DR: In this article , the authors discuss the programming effects of different types of stressors (social and nonsocial) occurring during adolescence (first hit) and how such stressors affect the responsiveness toward an additional stressor occurring during adulthood (second hit) in rodents.

TL;DR: In this paper , the authors explored the links of caregiving for a child with a congenital, chromosomal, or genetic disorder to the regulation or dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis.

TL;DR: In this paper , a systematic review and meta-analysis was performed to examine dose-response associations between 25-hydroxyvitamin D (25OHD) levels and cognitive performance in community-dwelling adults.