G
Gillian Einstein
Researcher at University of Toronto
Publications - 92
Citations - 3248
Gillian Einstein is an academic researcher from University of Toronto. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 25, co-authored 75 publications receiving 2671 citations. Previous affiliations of Gillian Einstein include Duke University & Linköping University.
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Journal ArticleDOI
Hypothesis: Microtubule Instability and Paired Helical Filament Formation in the Alzheimer Disease Brain Are Related to Apolipoprotein E Genotype
Warren J. Strittmatter,Karl H. Weisgraber,Michel Goedert,Ann M. Saunders,David Huang,Elizabeth H. Corder,Li Ming Dong,R. Jakes,Mark J. Alberts,John R. Gilbert,Seol Heui Han,Christine M. Hulette,Gillian Einstein,Donald E. Schmechel,Margaret A. Pericak-Vance,Allen D. Roses +15 more
TL;DR: The data point to the absence of an important function of apolipoprotein E-epsilon 3 or apoE2 in individuals who do not inherit these alleles as the genetically relevant metabolic factor, which has important implications for design of experiments directed toward understanding the relevant neuronal metabolism.
Journal ArticleDOI
Considering sex as a biological variable in preclinical research
Leah R. Miller,Cheryl Marks,Jill B. Becker,Patricia D. Hurn,Wei Jung Chen,Teresa K. Woodruff,Margaret M. McCarthy,Farida Sohrabji,Londa Schiebinger,Cora Lee Wetherington,Susan L. Makris,Arthur P. Arnold,Gillian Einstein,Virginia M. Miller,Kathryn Sandberg,Susan E. Maier,Terri L. Cornelison,Janine A. Clayton +17 more
TL;DR: This article is meant as a guide to preclinical investigators as they consider methods and techniques for inclusion of both sexes in preclinical research and is not intended to prescribe exhaustive/specific approaches for compliance with the new NIH policy.
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Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy.
TL;DR: The ability to detect and follow the early progression of amyloid-positive brain lesions will greatly aid and simplify the many possibilities to intervene pharmacologically in AD.
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Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study.
Seol Heui Han,Gillian Einstein,Karl H. Weisgraber,Warren J. Strittmatter,Ann M. Saunders,Margaret A. Pericak-Vance,Allen D. Roses,Donald E. Schmechel +7 more
TL;DR: It is suggested that apoE, which is presumably synthesized and stored by astrocytes, may be taken up by cortical neurons in younger adult humans, and could influence the rate of pathology in neurodegenerative diseases such as Alzheimer's disease.
Journal ArticleDOI
Apolipoprotein E Is Present in Hippocampal Neurons without Neurofibrillary Tangles in Alzheimer's Disease and in Age-Matched Controls
Seol Heui Han,Christine M. Hulette,Ann M. Saunders,Gillian Einstein,Margaret A. Pericak-Vance,Warren J. Strittmatter,Allen D. Roses,Donald E. Schmechel +7 more
TL;DR: Apolipoprotein E is localized where it may affect the biological expression of two characteristic AD pathological correlates: extracellular A beta deposition and intraneuronal tau metabolism and NFT formation.