Showing papers in "International Journal of Pharmaceutics in 2022"

TL;DR: In this paper , the molecular structure of niosomes, physicochemical characteristics of nonionic surfactants in their formulation, the influence of external stimuli on niosome, the many methods of Niosomes administration, and their diverse therapeutic qualities are all explored in this study.

TL;DR: In this paper , the authors discuss the best simulated environment and latest characterization techniques applied to protein corona (PC) analysis and the effect of PC on the biological behavior of targeting NPs engineered with different targeting moieties.

TL;DR: In this paper , the authors reviewed the marketed and in-development dry powder inhaler (DPI) products on the treatment of systemic diseases, their status in clinical trials, as well as the potential for COVID-19 treatment.

TL;DR: In this paper , the most frequently employed characterization procedures, from rheological approaches to printing parameters and settings, and discuss their relevance, limitations and drawbacks, and highlight future perspectives.

TL;DR: In this article , a review brings the light upon the use of aptamer-chitosan nanoparticles against cancer therapy and their role in the reduction of toxic effects, which can elevate the drug accumulation at the target site, reduce toxicity to non-cancerous cells, overcome drug resistance, and reduce dosing.

TL;DR: In this paper , daptomycin micelles-stabilized palladium nanoflowers (Dap-PdNFs) were prepared for the first time.

TL;DR: In this paper , the opportunities of nanotechnology-based drug delivery of natural wound healing therapeutics have been included in the present discussion with special emphasis on nanofibers, vesicular structures, nanoparticles, nanoemulsion, and nanogels.

TL;DR: The structure of polymeric micelles is suitable for the encapsulation of hydrophobic or low water-soluble drugs and provides protection against the normal uptake of foreign compounds by the reticuloendothelial system.

TL;DR: In this article , the potential of using MIL-100(Fe) metal-organic framework (MOF) for loading and controlling the release of dacarbazine (DTIC) was evaluated for in vitro treatment of melanoma.

TL;DR: The Dox@HSA-OA NPs were physicochemically characterized for particle size, zeta potential, drug loading, entrapment efficiency, stability, release, and hemocompatibility as discussed by the authors .

TL;DR: In this paper , a review of recent advancements in topical microemulsion systems related to the transport of active ingredients into the skin, including those with high molecular weight and high polarity, is presented.

TL;DR: In this paper , the authors give an overview of pickering emulsions focusing on topical applications and discuss some of the already investigated topical applications of nano-and microparticles used to stabilize Pickering emulsion.

TL;DR: In this article , a mucoadhesive buccal tablet containing LRX -loaded solid lipid nanoparticles (SLNs) was developed to enhance the drug solubility and bioavailability and achieve a controlled release pattern for a better anti-inflammatory effect.

TL;DR: In this paper , a series of liposomal formulations modified with the most well-known Transferrin receptor targeting peptides including T12 (also known as THR), B6, and T7 was developed and their brain targeting capability and selective glioma accumulation was comparatively evaluated in vitro and in vivo.

TL;DR: An overview of recent advances in the research on polymorphic drug systems including understandings on nucleation, crystal growth, dissolution, mechanical properties, polymorphic transformation, etc. as mentioned in this paper .

TL;DR: CMC-Sericin dressing has been shown to enhance diabetic wound healing in rats treated or untreated with insulin concurrently as discussed by the authors , and histopathological examinations manifested the skin tissue regeneration evidenced by the development of skin appendages like hair follicles and collagen deposition after treatment with CMC-sericin hydrogel.

TL;DR: In this article , the authors provided a comprehensive review of the use of gold nanoparticles for skin drug delivery, which would help the design of multifunctional systems for skin drugs delivery based on Gold nanoparticles.

TL;DR: In this paper , the authors report results from an extensive analysis of NDMA content along the active pharmaceutical ingredient (API) manufacturing process as well as two different drug product manufacturing processes and demonstrate that reduction of nitrite from excipients is an effective means to reduce NDMA in the drug product.

TL;DR: In this article , the authors mainly review the applications of choline-based ionic liquids, formed by choline and organic acid, in transdermal delivery, topical delivery, and oral delivery.

TL;DR: In this paper , the authors highlight robust and established prediction theories and experimental approaches for the selection of polymeric carriers for the development of stable amorphous solid dispersions (ASDs).

TL;DR: A review of the design, manufacture, and utilisation of amorphous solid dispersions (ASDs) in preclinical drug development, with a key focus on the pre-formulation assessments and workflows employed at AstraZeneca, is presented in this paper .

TL;DR: In this paper , a review of the potential instabilities that a formulation development scientist confronts throughout the development of liposomal formulations as along with the ways to overcome these challenges is presented.

TL;DR: In this article , the authors used thyme oil loaded hydrogel membranes composed of κ-carrageenan (CG) and polyethylene glycol (PEG), which can provide moist environment and prevent infections for rapid wound healing.

TL;DR: In this paper , the authors reviewed recent developments in the application of UAV-targeted microbubble destruction (UTMD) in the diagnosis and treatment of tumors, including the concept, mechanism of action, clinical application status, and advantages of UTMD.

TL;DR: In this article , a disulfiram prodrug (DQ)-loaded and glucose oxidase (GOD) conjugated copper (II)-based nanoscale metal-organic framework (MOF), MPDG, was used for tumor-specific, enhanced chemo-chemodynamic therapy.

TL;DR: In this article , using micelles formed by CUR conjugated hydroxyethyl starch (HES) as vehicles, dexamethasone (DEX)-loaded HES-CUR nanoparticles (DHC NPs) with desirable size, negative surface charge, good stability in the harsh gastric environment, and excellent ROS scavenging activity are developed as a colon-targeted oral formulation for treating IBD.

TL;DR: In this paper , the authors describe how these membrane-clocked NPs endow superior therapeutic effects by immune invasion; along with this, the development of membrane-coated NPs and their method of preparation and characterization has been clearly described in the manuscript.

TL;DR: In this article , a liquid self-nano-emulsifying drug delivery system (L-SNEDDS) of curcumin and quercetin was prepared by dissolving them in isotropic mixture of Labrafil M1944CS®, Capmul MCM®, Tween-80® and Transcutol P®.

TL;DR: In this article , a multiphysics model of deformation, swelling, and diffusion fields were coupled in a multi-physics model to optimize the drug delivery in order to accelerate the drug release.