Showing papers in "International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes in 1988"

TL;DR: An improved generator is developed for the production of the alpha emitting radionuclide 212Bi and its parent, 212Pb, which are well suited to use as radiotherapeutic agents due to their relatively short half lives and appropriate particle particle emissions.

TL;DR: Comparative blood clearance measurements in mice suggest that the 211 At-labeled IgG conjugate is stable in vivo.

TL;DR: The benzodiazepine receptor antagonist Ro 15-1788 has been labelled with 11C in two different positions and the radiochemical purity was in all cases greater than 99%.

TL;DR: In this article, a precise instrument and method of standardization of beta emitter radioactive solutions by liquid-scintillation counting is described, based on the extrapolation of counting rate to a value achieved when the triple to double ratio (TDCR) approaches unity.

TL;DR: In this paper, the efficiency of counting probabilities of different kinds of scintillation pulses upon energy of beta particles interacting with scintillator is derived and compared for double and triple detectors.

TL;DR: In this article, the influence of some irradiation parameters on the specific radioactivity of 18F was studied using two different target systems and nuclear reactions using water as target material, and the amount of stable fluoride present in the target water after irradiation was determined.

TL;DR: The isolation of the by-products which are formed with the authors' own kits, the evaluation of their biological behaviour and the comparison with the main product 99mTc-MAG3 in rats suggest that the radiochemical purity of 99m Tc- MAG3-preparations should be not less than 95%.

TL;DR: In this paper, the synthesis and purification of l -6-[18F]fluorodopa synthesized via the reaction of acetyl hypofluorite with a mercury-dopa derivative is described.

TL;DR: The presence of d -enantiomer in l -[methyl-11 C]methionine prepared from [ 11 C]CH 3 I and l -homocysteine thiolactone, was measured by high performance liquid chromatography using a reverse-phase column with an eluent containing l -proline and cupric acetate as mentioned in this paper.

TL;DR: In this article, an anion-exchange method was developed to separate no-carrier-added radioselenium, and the optimum energy ranges for the production of 73Se were found to be Ep = 40 → 30 MeV and Ed = 45 → 33 MeV.

TL;DR: The synthesis, purification, characterization and determination of specific activity are presented and discussed and Dexetimide, a potent muscarinic cholinergic receptor antagonist, and levetimide, its pharmacologically inactive enantiomer, were labeled with 11C for non-invasive in vivo studies of muscarinates receptors in the human brain using positron emission tomography.

TL;DR: In this paper, the use of high-resolution γ-ray spectrometry in the detailed analysis of low level samples for the 238U and 232Th decay chains is discussed.

TL;DR: An HPLC method based on ion pair chromatography was developed allowing the isocratic separation of all fluoroisomers of phenylalanine, tyrosine and dopa with a single column, showing higher regioselectivity and less side product formation with AcOF.

TL;DR: In this paper, the β-particle counting efficiencies for three-phototube liquid-scintillation counting systems were derived for double and triple coincidences by considering the probabilities for secondary-electron production at the first dynodes.

TL;DR: A simple procedure for producing 105Rh in 10-100 mCi quantities at specific activities of 700-10,000 Ci/mmol is described.

TL;DR: In this paper, the trichloroethylene is decomposed by γ radiation in a roughly first-order reaction; the initial G -value being 5.4 molecules/100 eV.

TL;DR: In this article, a high current gas target was constructed to test the 82Sr-production yield under actual production conditions using 36 MeV 3He-particles using natural krypton.

TL;DR: [11C]4'-Chlorodiazepam (RO5-4864), for PET studies of peripheral benzodiazepine receptors, was synthesized by alkylation of 1-desmethyl-4'-chlorodiazepum, in a small volume of acetone adsorbed on acrylic yarn, with [ 11C]methyl iodide in the injection loop of a liquid chromatograph.

TL;DR: In this paper, a regression equation was developed which relates the net loss of soil by erosion of black earth soils (kg ha−1 y−1) as a function of the measured loss of 137Cs activity in the soil expressed as a percentage of the normal input value.

TL;DR: [18F]GBR13119 is proposed as a new radiotracer for the presynaptic dopamine uptake system and small amounts of chemical impurity are identified as the nitro-substituted analog by independent synthesis.

TL;DR: In this article, LiAlH 4 was converted into several 11 C-compounds and their specific activities were measured by high performance liquid chromatography, and it was shown that only a negligible amount of CO 2 was brought with the irradiated target N 2 gas and that the carrier amount decreased remarkably with the reduction of the amount and concentration of the LiALH 4 THF solution but not to less than 0.2 μmol.

TL;DR: A synthesis of [11C]scopolamine capable of clinical delivery of this agent in high specific activity is described and it is shown that this agent can be delivered in clinical delivery using aqueous neutral potassium phosphite as the reducing agent.

TL;DR: Geometry-dependent effects upon the response of an omnidirectional detector and rectangular source configuration and a variant of the Wallace approximation is shown to produce values that do not vary from "exact" calculations by more than +/- 5%, often yielding results that are within +/- 1%.

TL;DR: Using existing robotic hardware and software programs developed for the synthesis of several positron-emitting radiopharmaceuticals for PET imaging, the additional automated synthesis of 2-deoxy-2-[18F]fluoro-D-glucose (2-[ 18F]FDG) has been incorporated into the Zymate Laboratory Automation System.

TL;DR: The Zymate robot, previously set up for the automated synthesis of 16 alpha-[18F]fluoroestradiol-17 beta, has been modified for the production of several short-lived radiopharmaceuticals in a single hot cell, representing a flexible and versatile alternative for the routine production of radiophARMaceuticals used in PET studies.

TL;DR: Preliminary findings support further testing of 3-[123 I]iodo- MK-801 and (+/-)13-[18F]fluoromethyl-MK-801 as possible agents for in vivo mapping of the glutamate receptor complex.

TL;DR: In this paper, effective atomic numbers (Zeff) of 12 different soil samples were computed for total photon interaction cross sections using theoretical data over a wide energy region from 10 to 5000 keV.

TL;DR: A serum fractionation with alcohol was carried out to prove that the albumin fraction of serum is responsible for the lanthanide binding in blood, and it is concluded that serum albumin binding predominates for the radiolanthanides.