Showing papers in "Journal of Heterocyclic Chemistry in 2022"

TL;DR: In this article , a simple and convenient one-pot method for the synthesis of N-substituted acridine derivatives from the condensation of 1,3cyclohexanedione, substituted aryl amines, and 1,2,3-triazole aldehydes using a mixture of water/ethanol as a reaction medium is reported.

TL;DR: In this article , the authors reviewed various pathways for the synthesis of isoxazole analogues and having a broad spectrum of bioactive actions, including anti-bacterial, anti-fungal and anti-inflammatory, anti cancer.

TL;DR: A series of fifteen hybrid analogs based on benzimidazole bearing triazole skeleton were synthesized and were evaluated for in vitro AChE and BuChE inhibition profile as mentioned in this paper .

TL;DR: In this paper , 40 pyrrolo[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives were designed and synthesized as cholinesterase inhibitor agents.

TL;DR: In this paper , 13 novel isatin-ampyrone Schiff bases derivatives were synthesized in only two steps of 70% to 90% overall yields and the structure-activity relationship of the tested compounds revealed that chlorine group at C-5 position of the isatin ring significantly increased the cytotoxic activity.

TL;DR: In this paper , a series of S-alkylated, N-alklyated, and N-glycosylated 2-thiohydantoin derivatives were synthesized via the reaction of (E)-5-(arylidene)-1-phenyl-2-thIOhydantoins 5a-d with alkyl halides/glycosy bromides under aqueous, anhydrous alkaline/ glycosylation conditions, respectively.

TL;DR: In this article , the authors summarized the applications of structurally diversified β-keto amides for the synthesis of five-membered heterocycles including furans, thiophenes, pyrroles, indoles, pyrazoles, triazoles, and their derivatives.

TL;DR: In this article , a review of papers published from 2016 to 2022 for the synthesis of organic heterocycles under the effect of ultrasound irradiation is presented, which encompasses the examples of ultrasound supported synthetic reactions of multicomponent one pot processes as well as different steps flow synthesis.

TL;DR: The α,α-difluoro-γ-lactam rings have been found to be the core structures of a large number of natural compounds and drugs with a wide range of biological activities as mentioned in this paper .

TL;DR: In this paper , the authors have synthesized and characterized 9 novel 5,6-diaryl-1,2,4-triazine derivatives (4a-i) using 1HNMR, 13CNMR, and HRMS spectra.

TL;DR: A series of novel 1-(3-chloropyridin-2-yl)-5-amino-4-pyrazole derivatives containing a 1,3,4-thiadiazole thioether or sulfone moiety were designed and synthesized as mentioned in this paper .

TL;DR: In this article , a series of diamides containing central amino acids were designed and synthesized to conformationally simulate chlorantraniliprole (CHL) insecticides, which exhibited excellent larvacidal potency against Mythimna separate and Plutella xylostella.

TL;DR: In this paper , two flavors precursors of methyl 2-methyl-5-(((2-methylbutanoyl)oxy)methyl)-1-propyl-1H-pyrrole-3-carboxylate and methyl 2.5-methylbutyric acid were synthesized using glucosamine hydrochloride and methyl acetoacetate as raw materials through cyclization, oxidation, alkylation, reduction, and esterification.

TL;DR: In this paper , a Groebke-Blackburn-Bienayme (GBB) type multicomponent synthesis of 3-anilinoimidazo[1,2-a]pyridines using commercially available building blocks such as aryl glyoxal, aniline, and 2-aminopyridine has been developed.

TL;DR: In this article , substituted fluoroquinolone derivatives, compounds 6-20 were designed, synthesized, and evaluated for antituberculosis and antibacterial activity, and compounds 14 and 18 were found to be the most active derivatives due to their MIC at 1.56 μg/ml.

TL;DR: In this paper , a cycloaddition protocol was used to prepare two series of (nicotinonitrile-chromene)-based bis(pyrazoles) in 82%-91% yields.

TL;DR: In this paper , a series of 2-phenylpyridine derivatives were designed and synthesized by incorporating alkenyl into 2-PNY moieties, which showed 100% inhibition against Abutilon theophrasti and Amaranthus retroflexus at 150 g a.i.

TL;DR: In this article , 25 novel amide derivatives containing an 1,3,4-oxadiazole moiety were designed and synthesized, and their antibacterial activity against Xanthomonas oryzae pv. oryzicola (Xoc) and Xanthomanas ORyzae (Xoo) were tested.

TL;DR: In this article , two simple mechanistic approaches are postulated for 7,8-DHISQ's 3 and 4 via heating with aqueous solution of potassium hydroxide.

TL;DR: In this paper , 17 new furan-substituted thiadiazolyl hydrazone derivatives bearing 4-nitrophenyl moiety were designed, synthesized and tested for their in vitro antimicrobial activity.

TL;DR: In this article , the authors comprehensively review and summarize a series of sustainable and facile synthetic strategies of phenazine derivatives and further discuss the approach of preparation and the superiority of each strategy.

TL;DR: In this article , the antimicrobial properties of the products were evaluated against five bacterial strains including Streptococcus pneumoniae, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Serratia marcescens.

TL;DR: Remdesivir (Veklury), Hydroxychloroquine appears to be the drug of choice and garnered unprecedented attention as potential therapeutic agents against the pandemic realized worldwide due to SARS‐CoV‐2 infection.

TL;DR: In this article , a review article summarizes the development of pyridazinone derivatives that are targets for numerous receptors such as C-met kinase inhibitors, PARP inhibitors, Tubulin polymerization inhibitors, Dihydro folate reductase inhibitors and B-Raf inhibitors.

TL;DR: In this paper , a three-component acid-catalyzed cyclocondensation of isomeric phenylenediamines with aldehydes and cyclopentadiene (CPD) was studied.

TL;DR: A simple and efficient iodine-promoted synthesis has been developed for the synthesis of isoxazolyl aryl thiazole amines (3) from easily available isoxoxolyl anonyl ethanones (1) and thiourea (2) in good yields as mentioned in this paper .

TL;DR: In this article , a single-crystal X-ray diffraction was used to characterize spiro-tetrahydrotetrazines of oxetan-3-one, which were analyzed using IR, EA, DTA, and multinuclear NMR spectroscopy.

TL;DR: In this article , the synthesis of isoindolin-1-one-three-phosphonates under catalyst-and solvent-free conditions was reported to afford the desired compounds in excellent yields with potent pharmacological properties.

TL;DR: A green and efficient protocol for a one-pot condensation of 1-(2,4-dinitrophenyl)-3-(thiophen-2-yl)-1H-pyrazol-5(4H)-one with aromatic and aliphatic aldehydes in different ratios to synthesize novel heterocyclic compounds containing pyrazolone and pyranopyrazole moieties was presented in this article .