Showing papers in "Journal of Investigative Dermatology in 2022"

TL;DR: In this paper , the role of TGFβ and Eph-ephrin signaling pathways in both the aberrant fibrogenesis and angiogenesis of keloids was highlighted.

TL;DR: In this article , the authors investigated the role of CAMKK2 in melanoma cell death modality triggered by iron-dependent lipid peroxidation and showed that CAMKKII was prominently activated in ferroptosis.

TL;DR: In this paper , the authors investigated the efficacy of epidermal stem cells and ESCs-derived exosomes (ESCs-Exo) in improving impaired diabetic wound healing and their mechanisms of action.

TL;DR: The primary cause of the increase in melanoma incidence in the United States has been suggested to be overdiagnosis as mentioned in this paper , however, melanoma in situ incidence has continued to increase throughout the population.

TL;DR: In this paper , a deep learning-based artificial intelligence model was proposed to automatically detect basal cell carcinoma (BCC) in reflectance confocal microscopy images, achieving an area under the curve for the receiver operator characteristic curve of 89.7% (stack level) and 88.3% (lesion level).

TL;DR: In this paper , the authors performed bacterial 16S ribosomal RNA gene amplicon sequencing on total DNA derived from the samples of individuals with Hidradenitis suppurativa (HS).

TL;DR: In this paper , the authors performed a longitudinal study to investigate the pubertyassociated shifts in skin microbiota and found significant alterations in the composition of skin microbial communities, transitioning toward a more adult microbiome, during puberty.

TL;DR: In this article , dupilumab, an IL-4/IL-13 receptor blocker, has been linked to emergent seronegative inflammatory arthritis and psoriasis that form part of the spondyloarthropathy spectrum.

TL;DR: The G protein-coupled MC1R is expressed in melanocytes and has a pivotal role in human skin pigmentation, with reduced function in human genetic variants exhibiting a red hair phenotype and increased melanoma predisposition as discussed by the authors .

TL;DR: In this paper , the mechanistic role of serine proteinase C1r, a component of the classical pathway of the complement system, in cSCC was investigated, and the results provided evidence for the role of C 1r in promoting the invasion of CSCC cells by increasing MMP production.

TL;DR: In this paper , the authors employed an integrative methodology for microbiome and metabolome analysis of skin surface samples collected from the volar forearm of healthy infants aged 3-6 months.

TL;DR: A randomized trial was conducted in a tertiary care institute in South Korea to validate whether artificial intelligence (AI) could augment the accuracy of nonexpert physicians in real-world settings, which included diverse out-of-distribution conditions as mentioned in this paper .

TL;DR: In this article , the authors performed a parallel multi-omics analysis by processing neonatal murine skin for single-cell Assay for Transposase-Accessible Chromatin sequencing and singlecell RNA sequencing separately, which revealed that fibroblast clusters could be sorted into papillary and reticular lineages on the basis of transcriptome profiling.

TL;DR: A comprehensive review of preclinical animal models of psoriasis has been provided in this paper , with each model having unique strengths and limitations, and some models translate better to human disease than others.

TL;DR: In this paper , an array-based high-throughput auto-antibody screening was used to identify specific IgG autoantibodies that recognize circulating and tissue antigens in Hidradenitis suppurativa.

TL;DR: The authors showed that short-term exposure to high glucose causes a rapid monocyte reprogramming, manifested by increased expression and secretion of IL-10, which in an autocrine/paracrine fashion reduces glucose uptake and transforms monocytes into an anti-inflammatory phenotype by dampening signaling through toll-like receptors.

TL;DR: In this article , the expression of two viral oncoproteins is regarded as a key mechanism driving Merkel cell polyomavirus positive MCC and a considerable proportion of virus-negative MCC is found in association with squamous cell carcinoma (SCC), suggesting coincidental collision, one providing a niche for the other, or evolving from the other.

TL;DR: The European Society of Dermatological Research (ESDR) celebrated its 50th anniversary during the annual meeting on 23-25 September 2021 as discussed by the authors . And a review on the pathogenesis of psoriasis can be found in this article.

TL;DR: In this article , the authors measured skin sodium content in patients with psoriasis and in age-matched healthy controls by Sodium-23 magnetic resonance imaging and found that patients with PASI > 5 showed significantly higher sodium and water content in the skin but not in other tissues than those with lower PASIs or healthy controls.

TL;DR: In this article , the authors collected samples for metagenomic and host skin factor analyses from the forearm, buttock, and facial skin from 158 Caucasian females aged 20-24, 30-34, 40-44, 50-54, 60-64, and 70-74 years.

TL;DR: In this article , a high-resolution analysis of shotgun metagenomes of actinic keratosis and SCC in healthy skin was performed to identify skin cancer associated changes in the skin microbiome.

TL;DR: In this article , the role of nuclear IL-33 in TSLP-induced epidermal barrier defects was investigated, and it was shown that nuclear IL33 acted as a cofactor of signal transducer and activator of transcription 3 in the TSLPs-induced transcriptional repression of hBD2, S100A7 and claudin-1.

TL;DR: A review of the current understanding of the central circuit mechanisms of itch in the brain can be found in this article , where the authors mainly summarize the current state-of-the-art in the literature.

TL;DR: In this article , the authors compared single-cell transcriptomic profiles of human epidermal cells from PU wound edges with those from uninjured skin and acute wounds in healthy donors, and found significant shifts in the cell composition and gene expression patterns in PU.

TL;DR: The mechanism underlying the progression of actinic keratosis (AK) and cutaneous squamous cell carcinoma in situ (SCCIS) to SCC remains unclear as discussed by the authors .

TL;DR: Pemphigus and pemgoid are paradigms for understanding the mechanisms of antibody-mediated autoimmune disease in humans as discussed by the authors , which holds promise to identify safer and more effective therapies for these potentially life-threatening diseases.

TL;DR: In this article , the authors used an IL-23 minicircle DNA-based murine model of psoriasiform dermatitis, and they showed that oral administration of secondary BAs, including lithocholic acid (LCA), deoxycholic acid, and 3-oxoLCA, significantly improved the T helper 17 cell function without inducing apparent hepatotoxicity.

TL;DR: In this paper , single-cell RNA sequencing and spatial transcriptomics were applied to uncover the underlying pathophysiology of keloids, which suggested a potential role of fibrovascular communication and mesenchymal activation of ECs that might be involved in the keloid pathogenesis.

TL;DR: In this article , the authors present an overview of the skin's barrier structure and its formation process, as evidenced by high-resolution cryo-electron microscopy (cryo-EM).

TL;DR: For example, Ortega-Loayza et al. as discussed by the authors investigated gene expression in pyoderma gangrenosum and found that important changes localize to the dermis or epidermis and whether non-ional skin from patients with PG shows subclinical signs of the disease.