Showing papers in "Journal of Laboratory and Clinical Medicine in 1967"

TL;DR: Glutathione peroxidase activity is found to be associated with a relatively stable, nondialyzable, heat-labile, intracellular component which is separable from hemoglobin, by gel filtration and ammonium sulfate precipitation.

TL;DR: The creatine phosphokinase activity of serum is determined by a procedure in which adenosine triphosphate, liberated by the action of the enzyme, is linked to the reduction of nicotinamide-adenine dinucleotide phosphate and the formation of reduced nicotinamides followed spectrophotometricically.

TL;DR: The specificity of the method is such that, of the compounds tested, only tryptamine produces appreciable fluorescence: one tenth of the molar fluorescence of tryptophan.

TL;DR: It is likely that the increased NADHNAD ratio effected by ethanol metabolism results in a shift of serotonin metabolism from the oxidative pathway to5-hydroxyindole acetic acid to the reductive pathway to 5-Hydroxytryptophol.

TL;DR: There was a high degree of correlation (R = 0.95) between the postinfusion viability of stored cells and poststorage adenosine triphosphate (ATP) levels, indicating the potential use of ATP determinations to predict in vivo red cell viability after in vitro storage.

TL;DR: The results of this study suggest that certain stressful situations may be diabetogenic not only because of the well-known release of epinephrine and the corticosteroids but also in part because of an increased release of growth hormone on the one hand and anEpinephrine-induced suppression of insulin secretion on the other.

TL;DR: A mathematical model has been elaborated, taking into account the random loss of cells as well as the broad normal distribution of cells in regard to specific gravity, to describe the distribution of red cells of different age at various levels in the gradient.

TL;DR: Blood from patients with hereditary spherocytosis showed a greater increase in viscosity and a marked decrease in filterability at the lower pH levels as compared to normal erythrocytes, suggesting that the mechanism of splenic sequestration in hereditary Spherocyte sequestration is due to the abnormal rigidity or decreased deformability of the spHerocyte at pH's less than 7.4.

TL;DR: The observed alteration of norepinephrine metabolism from the usual oxidative pathway to the reductive pathway could result in part from the increased NADH:NAD ratio resulting from ethanol metabolism or from competitive inhibition by acetaldehyde formed from the metabolism of alcohol.

TL;DR: Folic malabsorption caused by sustained alcohol ingestion may be added as a factor accounting for the observed low serum folate concentrations of alcoholics.

TL;DR: This one-stage factor VIII assay with a semiautomatic clot-timer and a commercial standard plasma is described, which is technically simpler, more quickly performed, and less subject to human error than existing methods.

TL;DR: Electroimmunodiffusion is described in which antigen diffuses, under the influence of an electric field, into a layer of agar containing specific antiserum, which is suitable for the measurement of immunoglobulins in small samples of dilute and unconcentrated biological fluids.

TL;DR: The oral administration of ethanol significantly depressed the clearance of microaggregated albumin in rats, and measurement of total radioiodine activity in the blood proved to be as useful as measuring the protein bound fraction, as little label was released during the 15 minute observation period.

TL;DR: The studies indicate that 1 L. of clinical dextran may produce abnormal platelet function in some subjects even when the bleeding time is not prolonged, which may account for the variable effect on the bleed time which has been reported.

TL;DR: The data suggest that certain platelet antigens are located at specific subcellular sites and that intracellular platelet fibrinogen may differ functionally from plasma fibr inogen.

TL;DR: Sustained Mg deficiency can impair repletion of muscle K, and there is an apparent dissimilarity in the rate of muscle depletion of the principal intracellular cations, a deficit of K being more readily achieved than for Mg.

TL;DR: In this paper, the authors used immunofluorescent techniques to study the localization of 7S γ-globulin (γG) in synovial membranes and in adventitia of vessels in patients with rheumatoid arthritis.

TL;DR: Serum levels of monoamine oxidase were determined in 119 adults with acute and chronic liver disease and positive correlations were found between increased enzyme activity and signs of portal hypertension and portal-systemic collateral circulation.