Showing papers in "Journal of Neuroimmunology in 2023"

TL;DR: In this paper , microglia plays a protective role in dopaminergic neuron survival during the initial phase of Parkinson's disease, and the investigation of the mechanisms of this effect in future studies will help elucidate the pathophysiology of PD.

TL;DR: In this paper , the authors examined severity and cognitive status in pediatric anti-NMDA receptor autoimmune encephalitis (NMDARE) by comparing objectives measures: modified Rankin score (mRS), CASE, and CALS.

TL;DR: In this article , a microdialysis (MD) probe was used to measure the levels of cytokines and chemokines in relation to intracranial pressure (ICP) and metabolites.

TL;DR: In this paper , a rare case of AQP4 and MOG-IgG double positive NMOSD patient effectively and safely treated with ofatumumab (OFA), a novel fully humanized anti-CD20 mAb.

TL;DR: In this paper , a meta-analysis of pooled odds ratios and 95% confidence intervals for post-encephalitis epilepsy risk were calculated, and the results showed that PEE was associated with coma, seizure, status epilepticus, cranial MRI abnormality, focal EEG abnormality and positive HSV in cerebrospinal fluid (CSF).

TL;DR: A review of the role of alpha-synuclein in support of the unique immune responses in the nervous system is presented in this paper , where the authors discuss the emerging functional role of α-synulein in the support of host immune responses.

TL;DR: In this article , the diagnostic performance of cerebrospinal fluid free light chains (FLC) measurements compared to oligoclonal bands (OCB) to support multiple sclerosis (MS) diagnosis was evaluated.

TL;DR: In this paper , the authors describe a unique case of seropositive myelin oligodendrocyte glycoprotein antibody disease (MOGAD) in an obese 13-year-old boy who presented with an isolated IH, bilateral optic disc swelling and sudden onset complete vision loss in one eye without radiological evidence of optic nerve involvement.

TL;DR: In this paper , the authors performed an independent PubMed search for mimickers of AEs or patients with alternative neurological disorders misdiagnosed as AE, and found that the lack of fulfillment of diagnostic criteria for AE, atypical neuroimaging findings, non-inflammatory CSF findings, and non-specific autoantibody specificities and partial response to immunotherapy were major confounding factors.

TL;DR: In this paper , the clinical phenotype of SARS-CoV-2-related CNS disease was described and evaluated using an antibody index as a tool to differentiate between a direct (viral) and indirect etiology.

TL;DR: In this article , the role of triggering receptor expressed on myeloid cells-1 (TREM1) in perioperative neurocognitive disorders (PND) was investigated.

TL;DR: In this paper , the anti-inflammatory effect of a potent and selective CXCR2 antagonist SB332235 in the BTBR mice was studied by using flow cytometry and western blotting.

TL;DR: In this article , a novel variant, C52Y, of canopy FGF signalling regulator 3 (CNPY3) from patients with familial NMOSD was reported, which showed that this variant showed a stronger interaction with GP96 and TLRs than with wild-type CNPY-3.

TL;DR: In this paper , the association of the NF-κB inflammatory signaling pathway with vitamin D status in older cerebral small vessel disease (SVD) patients was determined, and it was shown that low vitamin D is associated with an inflammatory response via NF-kB signaling, which could play a role in the etio-pathogenesis of SVD.

TL;DR: In this paper , the authors showed that LRP4 antibody positivity rarely occurs in patients with myasthenia gravis in the US, and that it can be seen in patients having non-myasthenic conditions.

TL;DR: In this paper , the authors show that treatment of Th17 transfer recipients with a highly selective inhibitor to the TAM family of tyrosine kinase receptors results in ataxia associated with a shift of the inflammatory infiltrate to the hindbrain parenchyma.

TL;DR: In this paper , the radiological follow-up of a patient with Sjögren's syndrome who consulted for limb weakness and visual loss, and fourteen years later developed sicca symptoms was presented.

TL;DR: A 77-year-old woman was admitted with HSV-1 encephalitis who presented with acute encephalopathy and seizure-like activity, but no seizures were detected on cEEG as mentioned in this paper .

TL;DR: Wang et al. as mentioned in this paper developed an immune-related prognostic signature (IPS) based on the PTEN-associated immune related genes (IRGs), and the IPS exhibited a powerful prognosis prediction capacity in different GBM cohorts.

TL;DR: The authors found that GFAP and Nrf2 decreased in the groups that received treatments alone or simultaneous during 8 weeks; even when the effect on the NRF2 was not pronounced, it showed a higher concentration when GFAP decreased.

TL;DR: A single-center, retrospective, case-control study of 86 pediatric cases presenting to Texas Children's Hospital between 2006 and 2022 showed that post-herpes simplex virus-1 meningoencephalitis (HSV ME) was a significantly more common preceding infection in the experimental group compared to control patients with idiopathic intracranial hypertension and there was no difference in remote HSV infection between the two groups as discussed by the authors .

TL;DR: In this paper , the authors discuss the use of 3D in vitro platforms to improve microglia modelling and their potential benefits to fast-track drug development for neurodegenerative diseases.

TL;DR: In this article , the use of anti-MAPK-activated protein kinase 2 FANA antisense oligonucleotides in a mouse model of contusional spinal cord injury (SCI) was described.

TL;DR: Extracellular vesicles (EVs) and their bioactive cargo have emerged as endogenous nanoparticles with great theranostic potential as diagnostic and prognostic biomarkers and ultimately as therapeutic candidates for precision nanotherapeutics as discussed by the authors .

TL;DR: In this paper , the microglial response to extracellular stimuli leads to activation of surface purine receptors P2X4、P2X7、P 2Y12, which mediate signal transduction through intracellular signalling cascades, such as the BDNF/TrkB, NLRP3/IL-1β and RhoA/ROCK signalling pathways, and release inflammatory mediators and cytokines that enhance pain by increasing the excitability of nearby neurons.

TL;DR: In this paper , a mouse model of neuromyelitis optica spectrum disorder (NMOSD) induced by AQP4 peptide immunization was created, which showed pathological features similar to NMOSD.

TL;DR: In this paper , the CSF sCD27 is associated with CD8+ T cells and B cells in relapsing-remitting multiple sclerosis (RRMS) and nine symptomatic controls using flow cytometry and multiplex electrochemiluminescence immunoassays.

TL;DR: In this paper , the presence of EBV infected B cells and EBV-specific CD8 T cells in the multiple sclerosis brain suggests a role for virus-driven immunopathology in brain inflammation.