Journal ArticleDOI
Dissolution Behavior of Crystalline Solvated and Nonsolvated Forms of Some Pharmaceuticals
Eli Shefter,Takeru Higuchi +1 more
TLDR
The results suggest that the tendency of many drugs to form such adducts provide pharmaceutical investigators a powerful tool in effecting rapid dissolution of highly insoluble substances.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1963-08-01. It has received 355 citations till now. The article focuses on the topics: Dissolution & Solubility.read more
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Drug Solubility: Importance and Enhancement Techniques
TL;DR: Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation, and so forth.
Journal ArticleDOI
Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations
TL;DR: It is hoped that this review will lead to a more direct approach to the characterization of pharmaceuticalsolids and ultimately to faster approval of regulatory documents containing information on pharmaceutical solids.
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Characterization of Habits and Crystalline Modification of Solids and Their Pharmaceutical Applications
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General principles of pharmaceutical solid polymorphism: a supramolecular perspective.
Barbara Rodríguez-Spong,Christopher P. Price,Adivaraha Jayasankar,Adam J. Matzger,Naír Rodríguez-Hornedo +4 more
TL;DR: Current understanding of pharmaceutical solids in terms of molecular recognition and complementarity provides new insights into the design and function of single and fully miscible, multiple-component solids with varying degrees of order, and in this way is leading the path to supramolecular pharmaceutics.
Journal ArticleDOI
Trends in solubility of polymorphs
TL;DR: The general trend reveals that the ratio of polymorph solubility is typically less than 2, although occasionally higher ratios can be observed, and anhydrate/hydrate Solubility ratios appear to be more spread out and higher than the typical ratio for nonsolvated polymorphs.
References
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The rate of solution of solid substances in their own solutions
TL;DR: In this paper, the effect of the concentration on the rate at which a solid substance dissolves in its own solution, has not heretofore been investigated, probably due to the experimental difficulties in the way of keeping the surface of the dissolving substance constant during the solution.
Journal Article
A stable iron reagent for determination of cholesterol.
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The structures of the pyrimidines and purines. VI. The crystal structure of theophylline
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The Heat Capacities, Entropies, and Heats of Solution of Anhydrous Sod um Sulfate and of Sodium Sulfate Decahydrate. The Application of the Third Law of Thermodynamics to Hydrated Crystals
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Über die Geschwindigkeit molekularer und chemischer Reaktionen in heterogenen Systemen. Erster Teil.
TL;DR: In this paper, the authors discuss the effect of all molekularen reactions in heterogenen systems, e.g., the Übergang von Wasser in Eis, von Eis in Wasser, the Ausscheidung von Salz aus einer übersättigten Lösung, the Auflösung of Salz, the Verdampfung von Flüssigkeiten, die Verdichtung von Dampf, the Erstarrung von Löungen and von festen L