Showing papers in "Journal of the Neurological Sciences in 1975"

TL;DR: Localised changes in nerve fibres found at the elbow in 5 ulnar nerves and under the flexor retinaculum in 5 median nerves are considered to be valid evidence of sub-clinical entrapment in apparently unaffected human subjects.

TL;DR: The formation of the myelin sheath both during original myelinogenesis and during remyelination after segmental demyelinations may be different from the generally accepted normal regular helical construction.

TL;DR: It is suggested that the central process of myofibril clumping results from a localised inability of the sarcomeres to relax which implies a defect in the mitochondria, Z-line or sarcoplasmic reticulum in Duchenne muscular dystrophy.

TL;DR: The SFEMG method is used to characterize the functional status of the motor unit and helps in diagnosis and in predicting prognosis, and abnormalities in clinically and electromyographically normal muscles are revealed.

TL;DR: The myokymia described here is of interest not only because of its genetic association with a movement disorder, but also because the muscle findings support a peripheral basis for the muscle movements.

TL;DR: This model of peripheral nerve ischemia has two advantages in comparison to models used before, namely that marked changes are produced in every cat, and there are no compression or stretching, or any manipulation of investigated nerves and thus there is no doubt that the changes are related to ischemIA.

TL;DR: Patients with daytime sleepiness present altered states of consciousness that must be considered as diagnostic indexes in differentiating epileptic syndromes from syndrome of daytime sleepness.

TL;DR: It is concluded that the peculiar susceptibility of Mongolian gerbils to cerebral infarction following acute unilateral common carotid artery ligation is not related primarily to lack of adequate collaterals between the anterior and the anterior cerebral arteries, but to the degree of adequate adequacy of communication between theterior cerebral arteries.

TL;DR: The specificity of anatomo-clinical observations were investigated on 776 out of 982 consecutive persons hospitalized at the University Psychiatric Clinic of Geneva and showed that Alzheimer's presenile dementia has a distinct dominant hereditary pattern and must be considered a separate entity.

TL;DR: The decreased number of maturing oligodendedrocytes in the premyelination stage indicates that the lack of myelin in Jimpy mice may be secondary to a disturbance in the differentiation of the oligodendroglial cell line.

TL;DR: The active established plaque in multiple sclerosis is characterized by hypercellularity at its edge and lipid phagocytosis (gitter cells) and the hyperactive early plaque shows cells throughout the lesion.

TL;DR: A pattern of autoimmune demyelination in EAE and EAN has been described which was encountered consistently and was sometimes more common than the better known phenomenon of active stripping of myelin by macrophages.

TL;DR: A review of the 17 published cases of intramedullary cysticercosis showed this condition to be clinically indistinguishable from spinal cord tumours, and no evidence for an ependymal route of spread could be adduced.

TL;DR: Neural abnormalities (area of amyelination) have been found in the cranial nerves and in the ventral cervical and lumbosacral roots of bar harbor dystrophic mice of both the severe and benign forms.

TL;DR: The electrophysiological abnormalities correlate with the pathological findings of hypomyelination in the Trembler mouse.

TL;DR: The specific in vitro response to P1L protein in Bell's palsy may suggest that an in vivo sensitization of lymphocytes to such self protein occurs in this condition, and that cell-mediated, probably post-infectious, autoimmune mechanisms may be an important factor in the pathogenesis of the paralysis.

TL;DR: Longitudinal sections of affected muscle fibres clearly showed that the morbid process involves a muscle fibre unevenly and not simultaneously over its entire length, and it is concluded that these latter two types of change are probably reactive in nature and are not ultimately lethal to the Muscle fibres involved.

TL;DR: Experimental allergic neuritis has been induced in 52 guinea pigs by the inoculation of rabbit peripheral nerve in Freund's adjuvant and the findings indicated persistent demyelination and remYelination with striking hypertrophic changes (onion bulb neuropathy).

TL;DR: It seems possible that sensory neurons degeneration occurs more commonly in Werdnig-Hoffmann disease than has previously been supposed but that it is less severe and develops more slowly than motor neuron degeneration.

TL;DR: Imbalance in degenerative and regenerative processes seems to be the basis of the chronic partial denervation observed in the nerves of alcoholic patients in this study.

TL;DR: The early histopathological and histochemical changes in distal myopathy are strikingly similar to those of myotonic dystrophy.

TL;DR: The results indicate that measles virus may be an active immunogen within the CNS in many MS patients and in some patients with chronic myelopathy, giving rise to an oligoclonal IgG antibody response.

TL;DR: The findings support the view that tardive dyskinesia is produced by a disturbance in the balance of central transmitters such that dopaminergic transmission is increased.

TL;DR: The previously-reported existence of cytoplasmic thalamic neuronal inclusions in myotonic dystrophy is confirmed, but differ in the observations of their ultrastructural appearance, and note that these inclusions bear no resemblance to previously described inclusion bodies.

TL;DR: It is suggested that the disease might be a separate clinical entity with the following characteristics: sex-linked recessive inheritance, unusual but not invariable late onset, slow progression, facial-bulbar and proximal spinal muscle involvement, and consistent fasciculations.

TL;DR: Investigation of muscle biopsy specimens from a 30-year-old man with proximal limb weakness revealed accumulations of red-staining material in the subsarcolemmal and intermyofibrillar regions of virtually every fiber (ragged-red fibers); these accumulations were rich in oxidative enzymes.

TL;DR: Antibodies directed against nicotinic cholinergic receptor protein have been obtained in rabbits injected with purified receptor protein and receptor-immunized rabbits showed a peripheral paralysis after 3–4 weeks, similar to patients with myasthenia gravis.

TL;DR: It is suggested that IgG in MS brains is acting more as a protective than as an autoimmune antibody, as well as in normal white matter, especially near old plaques.