Showing papers in "Molecular Immunology in 2022"

TL;DR: In this paper , the authors investigated the effects of GYY4137 on ferroptosis and autophagy in a mouse model of sepsis-induced acute lung injury by a mechanism that is not understood.

TL;DR: In this article , the authors examined whether pro-and anti-inflammatory cytokines are expressed in B cells of children with autism spectrum disorder (ASD) and compared them with TDC children.

TL;DR: In this article , SARS-CoV-2-specific humoral response was analyzed over time in a group of healthcare workers who underwent vaccination with BBIBP-CorV (Sinopharm) vaccine in Argentina.

TL;DR: In this article , the authors reviewed the discovery and function of TAP with a major focus on its role in cross-presentation in dendritic cells (DCs) and discussed a recently described emergency route of noncanonical crosspresentation that is mobilized in DCs upon TAP blockade to restore CD8 T cell cross-priming.

TL;DR: In this paper , the authors reviewed the characteristics of NK cells in the tumor microenvironment (TME) and discussed promising immunotherapy strategies that could utilize NK cell potential for cancer immunotherapy.

TL;DR: In this paper , the authors employed a lentiviral-mediated strategy to down-regulate TREM2 expression on microglia in the brain of APPswe/PS1dE9 transgenic mice and BV2 cells.

TL;DR: In this paper , the authors unmask whether miR-24-3p from M2 macrophages-derived exosomes (M2-exo) could protect against myocardial injury after sepsis.

TL;DR: In this article , the therapeutic effect of microRNA (miR)-223 in exosomes secreted by BMSCs on immune response in the progression of RA was investigated, and the targeting relationship between miR-223 and NLR family pyrin domain-containing 3 was predicted by bioanalytical software and verified by luciferase reporter assay and rescue experiments in vitro.

TL;DR: The role of IL-6-activated transcription factor STAT3, also known as STAT3α, in inducing CRP expression in human hepatoma Hep3B cells was investigated in this paper .

TL;DR: In this article , the authors investigated the regulatory effect of sodium butyrate (SB) on LPS-induced inflammatory conditions in bovine mammary epithelial cells (bMECs), with particular emphasis on oxidative stress, inflammatory response, apoptosis, and mitochondrial dysfunction.

TL;DR: In this article , it was shown that hypoxia-induced fascin-1 up-regulation promoted RA FLS migration and invasion through the STAT3/HIF-1α/fascin1 axis, which might represent a novel therapeutic target for the treatment of RA.

TL;DR: In this paper , exosomes derived from human bone marrow mesenchymal stem cells (BMSCs) play potential protective roles in spinal cord injury (SCI), however, the underlying mechanisms remain not fully elucidated.

TL;DR: Wang et al. as discussed by the authors investigated the mechanism of spleen injury caused by severe acute pancreatitis, and explored the application potential of tuftsin for relieving spleen damage in SAP mice.

TL;DR: In this paper , the implication of microRNA profile in the linkage between oxidized low-density-lipoprotein (oxLDL)-stimulated-macrophages (M) exosomes and vascular smooth muscle cells (VSMCs) during atherosclerosis was investigated.

TL;DR: In this paper , the authors showed that SVA 2B protein degraded mitochondrial antiviral-signaling protein (MAVS), a key host molecule in the innate immune pathway, and a colocalization and interaction between 2B and MAVS was observed in the context of viral infection.

TL;DR: In this paper , the LPxTG-motif protein (LMP) derived from Lactobacillus reuteri was analyzed in simulated gastrointestinal fluid and the anti-inflammatory activity of LMP was also evaluated in the LPS-stimulated RAW 264.7 cell model.

TL;DR: Zhou et al. as mentioned in this paper performed a sub-group analysis of m6A-modified LncRNA expression in the DN transcriptome dataset (LncRNA high-low expression group); the results showed that the presence of macrophage M1-related lncRNA (LINC00342, LINC00667, and LNC00963) in the process of methylation recognition and metastasis was indirectly related to the downstream demethylase FTO.

TL;DR: In this paper , the authors used a chemical complementarity scoring algorithm and an original web tool to establish aspects of electrostatic complementarity of the CTAs, MAGEA3 and MGAs, with melanoma specimen resident, T-cell receptor (TCR) complementarity determining region 3 (CDR3) amino acid sequences.

TL;DR: In this article , the authors investigated the therapeutic efficacy of J-113863, a novel CCR1 chemokine receptor, on PLP139-151-induced EAE in SJL/J mice.

TL;DR: In this article , the anti-asthma effects of Ephedrae Herba polysaccharides (PE) and possible mechanisms related to immune inflammatory response were investigated.

TL;DR: In this article , the m6A modification profile of SLE was established using MeRIP-seq, and the potential roles of n6A-related lncRNAs in SLE were investigated using qRT-PCR.

TL;DR: MaR2 has an obvious protective effect on OVA-induced bronchial asthma in mice, in a similar manner as Dexa, and the mechanism may be related to the inhibition of the Th2 type immune response, the NLRP3 inflammasome activation and oxidative stress.

TL;DR: In this paper , the authors identified C. bellicosus AK as an allergen and predicted IgE-binding epitopes through immunobioinformatic analysis.

TL;DR: Ehrlich et al. as mentioned in this paper showed that paroxysmal nocturnal hemoglobinuria is a complement-mediated disease, and they used the complement inhibitor Eculzimab/Soliris to treat it.

TL;DR: In this paper , the authors investigated the biological effects of LINC00665 on the progression of GC and explored the mechanisms underlying its ability to mediate the polarization of macrophages towards the M2 phenotype.

TL;DR: In this paper , the effect of Mat on joint synovial angiogenesis in the pathogenesis of rheumatoid arthritis has not been elucidated, however, previous studies have demonstrated its specific effect on relieving rheumaticoid arthritis (RA).

TL;DR: In this paper , a recombinant single-chain fragment variable (scFv) was used as a monoclonal antibody (MAb) platform targeting the receptor binding domain (RBD) of Spike protein of SARS-CoV-2.

TL;DR: In this paper, the effect of Mat on joint synovial angiogenesis in the pathogenesis of rheumatoid arthritis has not been elucidated, however, previous studies have demonstrated its specific effect on relieving rheumaticoid arthritis (RA).

TL;DR: In this paper , the authors investigated the roles of follicular helper T (Tfh) and FFR subsets in patients with primary Sjögren's syndrome (pSS) and evaluated the effects of sirolimus on these cells.

TL;DR: In this article , the effects of methylsulfonylmethane (MSM) against methicillin-resistant Staphylococcus aureus (MRSA) infection were evaluated.