Journal•ISSN: 0028-3940
Neuroradiology
Springer Science+Business Media
About: Neuroradiology is an academic journal published by Springer Science+Business Media. The journal publishes majorly in the area(s): Neuroradiology & Magnetic resonance imaging. It has an ISSN identifier of 0028-3940. Over the lifetime, 7423 publications have been published receiving 187369 citations.
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TL;DR: The theoretical background to diffusion tensor imaging and its commoner clinical applications, such as cerebral ischemia, brain maturation and traumatic brain injury, and its potential use in diseases such as epilepsy, multiple sclerosis, and Alzheimer's disease are reviewed.
Abstract: We review the theoretical background to diffusion tensor imaging (DTI) and some of its commoner clinical applications, such as cerebral ischemia, brain maturation and traumatic brain injury. We also review its potential use in diseases such as epilepsy, multiple sclerosis, and Alzheimer's disease. The value of DTI in the investigation of brain tumors and metabolic disorders is assessed.
444 citations
TL;DR: A new automated method based on support vector machine (SVM) classification of whole-brain anatomical magnetic resonance imaging to discriminate between patients with Alzheimer's disease and elderly control subjects has the potential in distinguishing patients with AD from elderly controls and therefore may help in the early diagnosis of AD.
Abstract: Purpose We present and evaluate a new automated method based on support vector machine (SVM) classification of whole-brain anatomical magnetic resonance imaging to discriminate between patients with Alzheimer’s disease (AD) and elderly control subjects. Materials and methods We studied 16 patients with AD [mean age±standard deviation (SD)=74.1±5.2 years, minimental score examination (MMSE)=23.1±2.9] and 22 elderly controls (72.3±5.0 years, MMSE=28.5±1.3). Three-dimensional T1-weighted MR images of each subject were automatically parcellated into regions of interest (ROIs). Based upon the characteristics of gray matter extracted from each ROI, we used an SVM algorithm to classify the subjects and statistical procedures based on bootstrap resampling to ensure the robustness of the results. Results We obtained 94.5% mean correct classification for AD and control subjects (mean specificity, 96.6%; mean sensitivity, 91.5%). Conclusions Our method has the potential in distinguishing patients with AD from elderly controls and therefore may help in the early diagnosis of AD.
438 citations
TL;DR: This study shows that spectroscopy added to MRI helps in tissue characterization of intracranial mass lesions, thereby leading to an improved diagnosis of focal brain disease.
Abstract: Diagnosis of primary and secondary brain tumours and other focal intracranial mass lesions based on imaging procedures alone is still a challenging problem. Proton magnetic resonance spectroscopy (1H-MRS) gives completely different information related to cell membrane proliferation, neuronal damage, energy metabolism and necrotic transformation of brain or tumour tissues. Our purpose was to evaluate the clinical utility of 1H-MRS added to MRI for the differentiation of intracranial neoplastic and non-neoplastic mass lesions. 176 mostly histologically verified lesions were studied with a constant clinically available single volume 1H-MRS protocol following routine MRI. 12 spectra (6.8%) were not of satisfactory diagnostic quality; 164 spectroscopic data sets were therefore available for definitive evaluation. Our study shows that spectroscopy added to MRI helps in tissue characterization of intracranial mass lesions, thereby leading to an improved diagnosis of focal brain disease. Non-neoplastic lesions such as cerebral infarctions and brain abscesses are marked by decreases in choline (Cho), creatine (Cr) and N-acetyl-aspartate (NAA), while tumours generally have elevated Cho and decreased levels of Cr and NAA. Gliomas exhibit significantly increased Cho and lipid formation with higher WHO tumour grading. Metastases have elevated Cho similar to anaplastic astrocytomas, but can be differentiated from high-grade gliomas by their higher lipid levels. Extra-axial tumours, i.e. meningiomas and neurinomas, are characterized by a nearly complete absence of the neuronal marker NAA. The additive information of 1H-MRS led to a 15.4%-higher number of correct diagnoses, to 6.2% fewer incorrect and 16% fewer equivocal diagnoses than with structural MRI data alone.
401 citations
TL;DR: Nine angiomatous malformations situated on the outer surface of the dura and one situated in the pelvis, from which draining veins pierced the dURA and joined the coronal venous plexus are described, suggesting that neurological deficiencies with both types of malformation are usually due to raised venous pressure with secondary ischaemic hypoxia.
Abstract: Nine angiomatous malformations situated on the outer surface of the dura and one situated in the pelvis, from which draining veins pierced the dura and joined the coronal venous plexus are described. The clinical manifestations and myelographic appearances are similar to those of the majority of intradural angiomatous malformations. This suggests that neurological deficiencies with both types of malformation are usually due to raised venous pressure with secondary ischaemic hypoxia.
382 citations
TL;DR: Evaluating the safety and efficacy of the recently available flow diverter “pipeline embolization device” (PED) for the treatment of intracranial aneurysms and dissections reveals that the PED procedure is technically straightforward.
Abstract: Introduction
The purpose of this study was to evaluate the safety and efficacy of the recently available flow diverter “pipeline embolization device” (PED) for the treatment of intracranial aneurysms and dissections.
346 citations