Showing papers in "Pathology International in 1979"
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TL;DR: Angiopathy of hepatic sinusoida in patients with wasting diseases or in those receiving androgens in coexistence with passive congestion of the liver appear to be factors in the pathogenesis of pleiosis hepatis.
Abstract: Nine cases of peliosis hepatis are reported; five of these were associated with the administration of androgen or anabolic androgenic steroids and a sixth with large doses of medroxy-progesterone acetate. In five instances, neoplasm was present as an underlying disease. Antemortem evidence of liver disease was detected in six of seven cases but was not severe and had not contributed to death. The pathogenesis of blood-filled cystic cavities is discussed and the literature reviewed. Angiopathy of hepatic sinusoida in patients with wasting diseases or in those receiving androgens in coexistence with passive congestion of the liver appear to be factors in the pathogenesis of pleiosis hepatis. ACTA PATH. JAP. 29: 457–469, 1979.
230 citations
TL;DR: A new classification for non‐Hodgkin's malignant lymphoma is proposed as the one suited for the Lymphomas in Japan, which is to provide a new subtype “pleomorphic” for those more or less rapid‐growing lymphomas of peripheral T‐cell nature, along with another subtype lymphoblastic, after Nathwani et al.
Abstract: A new classification for non-Hodgkin's malignant lymphoma is proposed as the one suited for the Lymphomas in Japan, which is to provide a new subtype "pleomorphic" for those more or less rapid-growing lymphomas of peripheral T-cell nature, along with another subtype lymphoblastic, after Nathwani et al. for those of central T-cell nature. The proposal is based on the result of the investigation by the Study Group for Histopathological Diagnosis on Malignant Lymphoma that (1) the presence of a significant number of T-cell lymphomas with peculiar "pleomorphism" is responsible for the very low reproducibility rate of histopathological diagnosis on the diffuse, mixed L&H type of Rappaport classification, and (2) the relative incidence of lymphoms as peripheral T-cell nature including the so-called adult T-cell leukemia is much higher in Japan than in the Western countries.
189 citations
TL;DR: Adult T cell leukemia was classified into two distinct types, monomorphic and pleomorphic, according to their histological and cytological features.
Abstract: Adult T cell leukemia was classified into two distinct types, monomorphic and pleomorphic, according to their histological and cytological features. The former type is composed of uniform neoplastic cells with round or slightly indented nuclei without any marked deformation. The latter type, on the other hand, occupies a unique position in lymphocytic leukemias with the following characteristics: a) onset in adulthood, b) an acute and subacute course, c) well-differentiated T cell origin of the neoplastic cells, d) pleomorphism of the neoplastic cells with markedly deformed nuclei, e) diffuse proliferation of the neoplastic cells without nodular pattern, f) histologically heterogeneous features of lymph nodes frequently admixing a cluster of normal lymphocytes, proliferation of macrophages and dendritic cells, and well-developed high endothelium venules, g) high incidence of skin lesions due to the infiltration of neoplastic cells, and h) exclusively limited localization of patients' birth places.
107 citations
TL;DR: Three hundred and sixty cases of breast cancer were collected from among the 63,000 female members of the RERF extended Life Span Study sample which includes atomic bomb exposed women and controls of Hiroshima and Nagasaki, and in studying of 5‐year survival, the following conclusions were obtained concerning its relationship to histopathological findings.
Abstract: Three hundred and sixty cases of breast cancer were collected from among the 63,000 female members of the Radiation Effect Research Foundation (RERF) extended Life Span Study sample which includes atomic bomb exposed women and controls of Hiroshima and Nagasaki. The relationship of these breast cancer cases to A-bomb radiation was sought, and in studying of 5-year survival, the following conclusions were obtained concerning its relationship to histopathological findings. The prognosis of the 50+ rad high dose group is the best, followed by the nonexposed group and the low dose group. The apparently better survival may be due to the fact that this group is heavily weighted in favor of those who were younger at the time of the bomb (ATB). There is no specificity of the histologic type of breast cancer in the survivors by dose. Nor is any significant difference observed in the distribution of tumor size and histological grade, though the survival rates of this series are worse than those of usual Japanese women with breast cancer. Cellular reaction is significantly marked in the stroma of carcinoma tissue in the high dose group. Immune reaction is considered to be strong in the affected site of breast cancer in the high dose group and this can be regarded as a finding suggestive of good prognosis. Further extended studies are therefore warranted.
57 citations
TL;DR: The submucosal heterotopic gastric glands were found with an intimate relation to the repeated mucosal damage and subsequent intestinal metaplasia, but had no specific relation to gastric carcinogenesis.
Abstract: The submucosal heterotopic gastric glands were found in 160 cases (10.7%) of 1500 resected stomachs; 15% in gastric ulcer, 9.9% in gastric carcinoma, 4% in duodenal ulcer and 11% in chronic gastritis. The heterotopic glands were usually found in the distal half of the stomach, diffusely or localized. Macroscopic submucosal tumor was found in 9 (5%) of 160 cases. Although the heterotopic glands were found with an intimate relation to the repeated mucosal damage and subsequent intestinal metaplasia, they had no specific relation to gastric carcinogenesis.
50 citations
TL;DR: The papillary type of C cell carcinoma of the thyroid is not an artifact but one of the histologic variations of this carcinoma.
Abstract: Two cases of papillary type of C cell carcinoma of the thyroid were reported. They showed papillary arrangement with fibrovascular stalk in properly fixed tissues. Histochemically argyrophil reaction was positive in the cytoplasm and amyloid deposited in the stroma. Ultrastructurally secretory granules were found in their cytoplasm. The papillary type is not an artifact but one of the histologic variations of this carcinoma.
48 citations
TL;DR: A clinicopathologic and electron microscopic study was performed on 35 cases of primary malignant peripheral nerve tumors, among which 12 developed in association with neurofibromatosis (von Recklinghausen's disease) and further 11 in keeping with anatomically discernible nerves in patients without neurofibia.
Abstract: A clinicopathologic and electron microscopic study was performed on 35 cases of primary malignant peripheral nerve tumors, among which 12 developed in association with neurofibromatosis (von Recklinghausen's disease) and further 11 in keeping with anatomically discernible nerves in patients without neurofibromatosis. Depending upon the histologically predominant pattern, these tumors were subdivided into three groups: 23 compact spindle cell, 6 myxoid, and 6 epithelioid varieties of the tumor. The common ultrastructures in three of the 35 tumors were as follows: 1) The cell membranes manifested characteristic infoldings and lamellar configuration. 2) The tumor cell surfaces were coated by occasional basal lamina or homogeneously electron-dense membranous material. 3) The cytoplasms contained well-developed organelles and a few neurosecretory-type granules. Differential points from other soft-tissue sarcomas were briefly discussed on the histologic basis. ACTA PATH. JAP. 29: 363–375, 1979.
45 citations
TL;DR: Among these tumors 628 were benign (96%), while there were only 23 malignant cases (4%).
Abstract: The present study consists of 651 cases of soft tissue tumors originating in the head and neck area. Among these tumors 628 were benign (96%), while there were only 23 malignant cases (4%). In the benign group hemangiomas showed the highest incidence (47%) followed by tumors of adipose tissue (19%) and those of peripheral nerves (12%). Rare tumors consisted of nodular fascitis, hibernoma, lipoblastomatosis, glomus tumor, granular cell tumor, and chondroma. The majority of cases in the malignant group were either those of muscle origin or blood vessel origin. Excepting for two cases of rhabdomyosarcoma of the embryonal type and two cases of angiosarcoma, all showed recurrence and/or metastasis and terminated in death. Three cases of liposarcoma of either well-differentiated or myxoid type had a good prognosis with all three living for 3 or more years without any recurrence. Other malignant tumors consisted of malignant schwannoma, fibrosarcoma, malignant fibrous histiocytoma, alveolar soft part sarcoma, and chordoma. The age, sex, anatomical location, and differential diagnosis have also been described.
44 citations
TL;DR: In this paper, a single injection of a small amount of anti-rabbit kidney duck γ globulin was shown to improve the cellular events in the glomerulus in rabbit Masugi nephritis.
Abstract: Cellular events in the glomerulus in rabbit Masugi nephritis were studied. After a latent period, severe proliferative glomerulonephritis occurred by the single injection of a small amount of anti-rabbit kidney duck γ globulin. The change was well recovered within 27 days.
43 citations
TL;DR: Malignant teratoma of the thyroid gland was found in a 19‐year‐old female and she was given a combined surgical and irradiation treatment, without any evidence of recurrence or metastasis.
Abstract: Malignant teratoma of the thyroid gland was found in a 19-year-old female. She was given a combined surgical and irradiation treatment. The tumor was 5.0·4.0·3.6 cm and located in the lower right lobe of the thyroid gland. Light and electron microscopical examinations revealed mature or immature derivatives of the three primordial germ layers. The dominant portion of the tumor was composed of numerous masses of cancerous epithelial cells, which were distributed randomly in the mesenchymal tissue. Tumor cells invaded and replaced the surrounding thyroid tissue with occasional tumor thrombi in the lumens of blood vessels. No metastatic tumor was found in the lymph nodes. The patient was given a course of external irradiation, a total dose of 4000 rads, to the right thyroid area. Eight months after surgery, she is well and without any evidence of recurrence or metastasis.
41 citations
TL;DR: The autopsy revealed, extensive metastases of bones, and other primary focus except that of the stomach could not be detected, in a 55‐year‐old Japanese female who died of adenocarcinoma originating from heterotopic gastric pancreas.
Abstract: A case of a 55-year-old Japanese female who died of adenocarcinoma originating from heterotopic gastric pancreas is presented. The autopsy revealed, extensive metastases of bones. Though careful examination was done, other primary focus except that of the stomach could not be detected. In review of literatures, 11 malignant tumors originating from heterotopic gastric pancreas could be found including our case.
TL;DR: The authors expressed the view that infantile Abrosarcoma should be separated from adult AbrosARcoma, because between these two types of Abroblastic cells there were marked differences in the histologic feature as well as in the age, sex and anatomical distributions.
Abstract: Histologic sections of 68 soft-tissue sarcomas initially diagnosed as fibrosarcoma were reviewed, and 36 were excluded because of revised diagnosis. The tumors from the remaining 32 patients were analyzed clinicopathologically, and were classifed into two types; the adult type (22 cases) and the infantile type (10 cases). The adult type fibrosarcoma occurred in adults aged 25 to 67 years and consisted of spindle-shaped fibroblastic cells which formed interlacing bundles accompanied by variable amounts of collagen or reticulin fibers. The infantile fibrosarcoma affected children below the age of seven years in this series and was characterized by proliferation of immature fibroblasts forming indistinct bundles, frequently exhibiting areas of an angiosarcoma-like pattern and cavernous blood vessels. The authors expressed the view that infantile fibrosarcoma should be separated from adult fibrosarcoma, because between these two types of fibrosarcoma there were marked differences in the histologic feature as well as in the age, sex and anatomical distributions.
TL;DR: It was concluded that the tumor was neuroepithelioma derived from a primitive stem cell of neural crest origin which possesses the bipotency to differentiate toward either neuroblastic or neurilemmal line.
Abstract: A case of primitive neuroectodermal tumor arising in the cervical nerve root of a 28-year-old man is presented. Histologically, the tumor was characterised by proliferation of primitive neuroectodermal cells and formation of numerous Homer-Wright type rosettes. A cell line (Nagai line) was established from the tumor. Electron microscopic examination of Nagai cells revealed numerous microrosette formation with microvilli-like cytoplasmic processes projecting into the central lumina. Neurosecretory granules appeared in the cytoplasmic processes when Nagai cells were treated with dibutyryl cyclic AMP. Primitive satellite cells which completely surrounded other tumor cells with their tongue-like slender cytoplasmic processes were also found. Histogenesis of this unique tumor was discussed comparing with the neuroblastoma of sympathetic nervous system, medulloblastoma of the central nervous system, and with the tumors induced by Adenovirus type 12 in animals. It was concluded that the tumor was neuroepithelioma derived from a primitive stem cell of neural crest origin which possesses the bipotency to differentiate toward either neuroblastic or neurilemmal line.
TL;DR: It is concluded that this index accurately expresses the grade of pulmonary arterial change in the whole pulmonary arterials system in any given case and makes possible a detailed statistical analysis of large numbers of cases.
Abstract: A new method to quantitatively evaluate pulmonary arterial change in pulmonary hypertension is presented in this paper. Hypertensive pulmonary arterial changes are classified into four grades according to severity and a score from 1 to 4 is given to each arterial change according to the grading. An index of pulmonary vascular disease is then defined as a relative mean value of all scores. It is concluded that this index accurately expresses the grade of pulmonary arterial change in the whole pulmonary arterial system in any given case and makes possible a detailed statistical analysis of large numbers of cases.
TL;DR: Morphological changes in the spleens of patients with idiopathic portal hypertension were studied and compared with the normal spleen, showing increased volume of red pulp and many channels formed by reticulum cells and running parallel with each other along the central artery.
Abstract: Morphological changes in the spleens of patients with idiopathic portal hypertension (IPH) were studied and compared with the normal spleen. The study used (1) light microscopy with histometry, (2) scanning electron microscopy (SEM) of the splenic tissue with histometry and (3) SEM of the spleen vascular replica. Histometrical studies by light microscopy showed that the volume of red pulp of IPH was increased in a unit area and to a total of 12 times the normal in the whole spleen. The white pulp was scanty of lymphocytes and decreased in a unit area but it was increased in the whole spleen. SEM of the white pulp of IPH demonstrated many channels formed by reticulum cells and running parallel with each other along the central artery. This finding presumably corresponds to periarterial fibrosis in light microscopy. SEM histometry demonstrated that the venous sinuses of IPH were small but increased in number and occupied the same percentage area in a unit red pulp area as in the normal spleen. The Billroth cord of IPH was narrowed and occupied by thickened reticulum cells, which may cause increased pooling and destruction of blood cells in the enlarged spleen (hypersplenism). SEM of the tissue and vascular replica demonstrated open arterial termination in the Billroth cord in the spleen of IPH as well as in the normal spleen. Venous sinuses in the replica of IPH ran parallel with each other forming bundles with fewer intercommunications than normal.
TL;DR: Although there was apparent sex difference in the incidence and background of hypertension, male SHR rats might be a useful animal model of human periarteritis nodosa.
Abstract: SHR rats (Nihon Rat Inc.) were used to study spontaneous arterial lesions morphologically resembling human periarteritis nodosa (PN). Male SHR rats (159) developed PN in 76.1%, whereas females (39) in 10.3% during a period of 2 to 15 months of age. The frequency of PN in male SHR rats tended to increase with ageing and reached 100% at 9 months of age. PN lesions were widely distributed with only the lungs, brain and aorta being spared. PN in females was restricted to the tongue, parametrium and mesenterium, Male SHR rats with hypertension of more than 180 mm Hg showed PN in 81.7%, whereas in females with the same hypertension PN was found in only 17.4%. Although there was apparent sex difference in the incidence and background of hypertension, male SHR rats might be a useful animal model of human PN.
TL;DR: Morphogenesis of the granulomatous lesions and histochemical and ultrastructural correlation of storage cells in this disorder were discussed and the cytoplasm of foam cells was filled with membrane‐bound storage inclusions which consisted of so‐called curvilinear tubular structures.
Abstract: The first case of Farber's disease in Japan was reported, which was confirmed clinically, biochemically and pathologically. Soon after birth, the patient started developing hoarseness, stridor, fever, muscle hypotonous with retarded psychomotor functions including incapability of sitting alone and head control, joint swelling, subcutaneous nodules, albuminocytologic dissociation in cerebrospinal fluid, nodular corneal opacity, and abnormal findings in electroencephalogram. Lipid analysis on the material obtained from a subcutaneous nodule confirmed the presence of ceramide. Pathologically, the subcutanoues nodules were made up of granulomatous lesions displaying varied histological pictures, i.e., from cellular to fibrous areas depending on the disease progress. In the beginning, cells were mostly spindle-shaped, and as these cells were getting more round and larger, cells manifested the morphology of foam cells. Spindle-shaped cells were positive for periodic acid-Schiff and acid mucopolysaccharide stainings. This particular substance disappeared almost entirely in typical foam cells. Electron microscopically, the cytoplasm of foam cells was filled with membrane-bound storage inclusions which consisted of so-called curvilinear tubular structures. Morphogenesis of the granulomatous lesions and histochemical and ultrastructural correlation of storage cells in this disorder were discussed.
TL;DR: It is concluded that the distribution and incidence of argyrophil cells in the ductal epithelia is related to chronic pancreatitis, and in particular to regenerative processes.
Abstract: The silver positive cells of the exocrine pancreas and primary pancreatic cancers were studied with the Grimelius silver stain and the Fontana-Masson technique. In the pancreas, cells containing black granules with the Grimelius method, which at the same time react negative to Fontana-Masson, are considered argyrophil. These cells were present in the basal portion of some of the acinar tissue and in the ductal epithelia, as well as in the A cells of islets. The incidence and distribution of these argyrophil cells were also studied in a variety of ductal lesions. In the so-called ductal proliferation numerous numbers of positive cells were found. Argyrophil cells were frequently situated in the basal portion of ductal squamous cell metaplasia. In goblet cell metaplasia the numbers were few, and less than in normal ducts. We concluded that the distribution and incidence of argyrophil cells in the ductal epithelia is related to chronic pancreatitis, and in particular to regenerative processes. The incidence of argyrophil cells in primary pancreatic cancer, excluding islets cell origin, was 18 per 41 cases (43.4%). We considered them pancreatic cancer with argyrophil cells. ACTA PATH. JAP. 29: 413–419, 1979.
TL;DR: Male SHR rats from Nihon rat Inc. developed spontaneously periarteritis nodosa with high incidence and the initial changes, however, were subdivided into two types according to the arterial size involved.
Abstract: Male SHR rats from Nihon rat Inc. developed spontaneously periarteritis nodosa with high incidence. Macroscopically, periarteritis nodosa was obvious in the mesenteric arteries as bead-like or lead-pipe-like appearance. Microscopically, the lesion was compatible with Abrinoid arteritis and similar to that of human periarteritis nodosa. On the morphological basis, the preceding changes of the artery might be regarded as the medial damage especially of smooth muscle cells. The medial smooth muscle cells underwent degenerative changes and disappeared with an increase in basement-membrane-like substance and then the blood plasma and plasma proteins insudated into the subendothelial space frequently with leukocytic inflltration, and resulted in full-blown Abrinoid arteritis. The initial changes, however, were subdivided into two types according to the arterial size involved. In the large-sized arteries, leukocytic inflltration or fibrinous insudation without rupture of the internal elastic membrane was frequently observed. In the small-sized arteries, insudation of blood plasma and dissolution of the internal elastic membrane occurred simultaneously.
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TL;DR: Twelve patients with this benign subcutaneous tumor were selected from about 8,000 cases of soft tissue tumors in the authors' files, and the clinical and pathologic features of this tumor were reviewed and analyzed.
Abstract: Spindle cell lipoma is an unusual and special type of lipoma which has been occasionally misdiagnosed as liposarcoma by histopathologic examination. Twelve patients with this benign subcutaneous tumor were selected from about 8,000 cases of soft tissue tumors in our files, and the clinical and pathologic features of this tumor were reviewed and analyzed. The lesion exclusively affected adult males, and the nuchal region was the site of predilection. Microscopically, it is composed of an admixture of mature fat cells and fibroblastic spindle cells, accompanying collagen and reticulin fibers interspersed in a rich mucoid substance. The follow-up information of the patients has revealed a benign clinical course.
TL;DR: These two conditions are both so unusual for gastric carcinoma that only nine pertinent cases with heterotopic ossiflcation and two authentic cases with psammomatous calcification have been reported in the literature.
Abstract: Two cases of heterotopic ossification occurring in a carcinoma of the stomach are reported. In one of these cases, bone formation is seen only in the regional metastasis, while in the other case, it is found in the primary tumor alone. In addition, there is seen in the former case a deposit of laminated psammoma bodies in the primary tumor and its regional metastasis. These two conditions are both so unusual for gastric carcinoma that only nine pertinent cases with heterotopic ossiflcation and two authentic cases with psammomatous calcification have been reported in the literature. The feature of these conditions la described and the pathogenesis discussed on the basis of personal Findings and a review of literature.
TL;DR: In lung carcinomas induced in mice, the number of carcinomas and the time of detection of the Arst carcinoma per tumor‐bearing animals were greater and faster in the group with chrysotile plus MNU than either ch Chrysotile or MNU alone, suggested that chrysOTile asbestos had a promoting or cocercinogenic effect on some carcinogens in the respiratory tract.
Abstract: The cocarcinogenic effects of asbestos are presented. In lung carcinomas induced in mice, the number of carcinomas and the time of detection of the Arst carcinoma per tumor-bearing animals were greater and faster in the group with chrysotile plus MNU than either chrysotile or MNU alone. This suggested that chrysotile asbestos had a promoting or cocercinogenic effect on some carcinogens in the respiratory tract. In the group treated with chrysotile alone, a tumor was found in the right pleural cavity at 15 months. This tumor microscopically was similar to the biphasic form of the human diffuse mesothelioma. Microvilli, basement membrane, and junctional apparatus were seen by electron microscope, but other cytoplasmic organelles of the tumor cells were relatively scanty. Two peritoneal tumors developed in gastric and intestinal serosa at 11 and 12 months. Light and electron microscopic studies suggested that the tumors were probably myosarcomas or Abrosarcomas. ACTA PATH JAP. 29: 421–433, 1979.
TL;DR: Three types of focal atrophy of the seminiferous tubule, A, B and A+B type, were recognized in the 250 testes obtained from human subjects who died of acute death and it is suggested that A and B‐type are brought about by locally limited ischemia in relation to circulatory disturbance with arteriolar hyalinosis which commonly appears focally in the postpuberal testis.
Abstract: Three types of focal atrophy of the seminiferous tubule, A, B and A+B type, were recognized in the 250 testes obtained from human subjects who died of acute death. The A-type consists of complete hyalinized scarring of the tubule and the B-type of varing degrees of tubular collapse. The A+B type shows combined atrophy of A and B-type in which B-type occurs peripherally to A-type occlusion in sequence and might be induced by local obstruction of luminal flow. Focal tubulitis is uncommon but has been observed in the A+B type atrophy which is characterized by sperm retention and the presence of sperm-phagocytic macrophages in the lumen. Areas around the rete testis and periseptal zones of the testis are preferential sites for tubular atrophy. B-type atrophy as an abortive form of A-type is predominant in the younger groups of the second to third decades, and the incidence of A-type increases after the fifth decade. It is suggested that A and B-type are brought about by locally limited ischemia in relation to circulatory disturbance with arteriolar hyalinosis which commonly appears focally in the postpuberal testis.
TL;DR: An autopsy case of adult T‐cell luekemia with generalized cytomegalic inclusion disease and pneumocystis carinii pneumonia is reported, and presumed correlation of adultT‐cell leukemia, cutaneous T‐ Cell lymphoma and T‐ cell lymphoma was discussed.
Abstract: An autopsy case of adult T-cell leukemia with generalized cytomegalic inclusion disease and pneumocystis carinii pneumonia is reported. Tumor cells had T-cell characteristics (E-rosette) and cerebriform nucleus similar to Sezary cells. Generalized lymphadenopathy, hepatosplenomegaly and an ectopic pancreas in the ileum were found at the time of autopsy. Histologically, leukemic infiltration was observed in almost every organ, and perivascular infiltration, vascular invasion were conspicuous findings. Cytomegalic inclusion bodies were observed in most organs (lungs, salivary glands, pancreas, liver, ectopic pancreas, sweat gland, stomach, thyroid gland, pituitary body, etc.). An acute hepatitis, probably caused by cytomegalovirus, was also noted. Presumed correlation of adult T-cell leukemia, cutaneous T-cell lymphoma and T-cell lymphoma was discussed.
TL;DR: Calcium deposition could not be a direct effect of hypercalcemia, but the functional activity of smooth muscle cells did seem to promote the mineralization of calcium and phosphate, and vitamin D‐induced sclerosis did not prevent intimal thickening of the arteries when vitamin D was withdrawn.
Abstract: The early fine structural changes in the arteries of rats induced by excess vitamin D, perorally or parenterally were essentially similar, except the latter had a more prominent toxic effect to the vascular wall. The ultrastructural features, incidental to calcification, included the appearance of increased ground substance with a separation of collagenous and elastic fibrils, and degenerative changes in smooth muscle cells. Atherosclerosis was greatly accelerated at the sites of vascular injury when cholesterol, cholic acid and thiouracil were added to the basal diet. Calcification was initially observed in relation to elastic fibrils or degenerated cells in the upper and middle layers of the arteries, although there were few such deposits in the thickened intima of the coronary arteries. Calcium deposition could not be a direct effect of hypercalcemia, but the functional activity of smooth muscle cells did seem to promote the mineralization of calcium and phosphate. Furthermore, vitamin D-induced sclerosis did not prevent intimal thickening of the arteries when vitamin D, was withdrawn. ACTA PATH. JAP. 29: 545–5562. 1979.
TL;DR: Immunohistochemical study using immunoglobulin‐enzyme bridge technique demonstrated IgA and K‐type light chains in the majority of plasma cells infiltrated in the stomach, suggesting a plasmacytoma of multicentric gastrointestinal origin.
Abstract: A case of gastrointestional plasmacytoma found in a renal transplant recipient is described. Immunohistochemical study using immunoglobulin-enzyme bridge technique demonstrated IgA and K-type light chains in the majority of plasma cells infiltrated in the stomach. Pathological investigation revealed multiple similar tumors in the ileum, cecum and ascending colon suggesting a plasmacytoma of multicentric gastrointestinal origin. The pathogenesis of plasma cell tumors is briefly discussed with regard to organ transplantation. ACTA PATH. JAP. 29: 661–668, 1979.
TL;DR: The clinical and pathological findings of 6 cases of different types of anomalies of the tracheal cartliage were described and an attempt was made to correlates types of trachesal cartilage anomalies and the malformations in the other organs.
Abstract: This report described the clinical and pathological findings of 6 cases of different types of anomalies of the tracheal cartliage. Literatures of tracheal anomalies were reviewed and an attempt was made to correlates types of tracheal cartilage anomalies and the malformations in the other organs. Classical type of tracheomalacia is not usually associated with the other malformations. The cases with fatal tracheal cartilage anomalies usually show malformations in other organs, particularly in the respiratory and osteocartilaginous system. Tracheal cartilage anomalies may be one of the important elements in the cases of systemic abnormalities of the osteoCartilaQinous anomalies.
TL;DR: Extranodal formation of lymphoid follicles was morphologically studied in experimental bronchopneumonia and a loose network of mesenchymal cells and early infiltration of macrophages, following stromal edema seemed to play an important role in the early accumulation of lymphocytes.
Abstract: Extranodal formation of lymphoid follicles was morphologically studied in experimental bronchopneumonia. Control gnotobiotic mice had no peribronchial lymphoid follicles and only lymphatic vessels were traced from the terminal bronchiolar region toward larger bronchi. During the week after intranasal inoculation of mycoplasma pulmonis, lymphoid follicles developed in the terminal portion of the lymphatics by the accumulation of small lymphocytes. A loose network of mesenchymal cells and early infiltration of macrophages, following stromal edema, seemed to play an important role in the early accumulation of lymphocytes. Blastic transformation was seen frequently in the center of the accumulated lymphocytes. Two weeks after inoculation plasma cells emerged conspicuously in the periphery of the lymphoid follicles, and the acute phase of bronchopneumonia began to subside. Typical germinal centers with tingible body macrophages and dendritic reticulum cells developed when the bronchitis perisisted in a chronical manner. ACTA PATH. JAP. 29: 533–543, 1979.
TL;DR: The ultrastructure of benign osteoblastoma of the maxilla in a 14‐year‐old boy was studied and was characterized by the presence of abundant rough‐surfaced endoplasmic reticulum and several Golgi complexes that indicated the pronounced activity of collagenous fiber synthesis and the matrix of the osteoid tissue.
Abstract: The ultrastructure of benign osteoblastoma of the maxilla in a 14-year-old boy was studied. Morphologically, the tumor tissue was composed of abundant osteoid of a trabecular form, and cellular and vascular connective tissue. The cellular components were osteoblasts, osteoclasts, osteocytes entrapped within the osteoid, and small perivascular cells of two types. The small cells of one type were ovoid and had a relatively large nucleus and a dark cytoplasm. The cells of the other type were elliptical and had a clear cytoplasm. The former seemed to be a preosteoblast and the latter could not be identified. The osteoblast was the predominant cell in this lesion and was characterized by the presence of abundant rough-surfaced endoplasmic reticulum and several Golgi complexes. These characteristics indicated the pronounced activity of collagenous fiber synthesis and the matrix of the osteoid tissue.
TL;DR: A 14‐month‐old boy, clinically diagnosed as GM1‐gangliosidosis, died of respiratory insufficency and was autopsied except for the brain and was characterized by marked accumulation of foam cells in the pulmonary alveolar spaces.
Abstract: GM1-gangliosidosis is a disease characterized by abnormal accumulation of GM1-ganglioside in the brain and viscera. The disease is characterized by clinical findings similar to Hurler's disease and pathologic features resembling Niemann-Pick's disease but with involvement of the glomerular epithelium. A 14-month-old boy, clinically diagnosed as GM1-gangliosidosis, died of respiratory insufficiency and was autopsied except for the brain. Biochemically, marked increase of GM1-ganglioside in the viscera was demonstrated. Pathologically, the foam cells were present in the viscera. Some parts of the cytoplasmic vacuoles in the lungs and spleen contained osmiophilic fibrillar material electron-microscopically. This case was characterized by marked accumulation of foam cells in the pulmonary alveolar spaces.