Showing papers in "Pharmacological Research in 1998"

TL;DR: The result shows that ISO induced oxidative stress and the increase of the antioxidant system in tissues may attenuate oxidative stress.

TL;DR: In vivo data show that P-glycoprotein contributes to the elimination of many drugs by mediating their direct secretion from the blood into the intestinal lumen, and there is also evidence that this protein can limit oral drug absorption.

TL;DR: Owing to its combined dual mechanism of action, nebivolol leads to a unique haemodynamic and therapeutic profile by which it may be advantageous in essential hypertension, ischaemic heart disease and congestive heart failure.

TL;DR: Esculetin, a phenolic compound found in Cichorium intybus and Bougainvllra spectabillis, was investigated for its possible protective effect against paracetamol and CCl4-induced hepatic damage as mentioned in this paper.

TL;DR: The results suggest that NO appears to play a role in the LPS-induced septic shock model in mice, and may also suggest that other mediators, such as arachidonic acid products and cytokines play a roles in septicshock pathogenesis as well.

TL;DR: Results obtained have shown alterations in the antioxidant status following ulceration, indicating that free radicals seems to be associated with the pylorus ligation induced ulcers in rats.

TL;DR: Lupeol, a pentacyclic triterpene was isolated from C. nurvala stem bark and its ester lupeol linoleate was synthesised and these triterpenes were tested for their anti-inflammatory activity in complete Freundas adjuvant induced arthritic rats.

TL;DR: It is proposed that inhibition of SSAO may decrease the formation of these cytotoxic products and therefore prevent or slow the development of late-diabetic complications.

TL;DR: In anaesthetised rats, DDA produced significant falls in mean arterial blood pressure and heart rate in a dose-dependent manner and supported the bradycardia-inducing and beta-adrenoceptor antagonistic properties of DDA in vivo.

TL;DR: It appears that Ocimum sanctum leaf extract is antithyroidic as well as antioxidative in nature.

TL;DR: The purpose of this review is to analyse critically the present knowledge on purine release, and in particular the role of these substances as modulators of the nervous transmission.

TL;DR: Results indicate that tryptophan and some of its metabolites possess analgesic properties.

TL;DR: The results suggest that the septo-hippocampal projections are involved in spatial memory but not in object recognition whereas the integrity of Substantia Inno minata/Ventral Pallidum does not seem critical for either task.

TL;DR: An overview of agents with antiangiogenic activity and the early clinical experience with these drugs is provided to provide an overview of the most promising novel target for anti-cancer therapy.

TL;DR: A series of thioureido derivatives of acetophenone semicarbazone were synthesized and evaluated for anticonvulsant activity and some compounds provided significant protection against maximal electroshock and subcutaneous pentylenetetrazol induced seizures.

TL;DR: There was inhibition of the Schultz-Dale response in sensitised guinea pig ileum, but the bronchospasm induced by histamine could not be antagonised or prevented by Picroliv, indicating the absence of a direct post-synaptic histamine receptor blocking activity.

TL;DR: Hyperthyroidism tends to enhance lipid peroxide content and an increase in GST and decreases in GPx, vitamin E and ascorbic acid levels accompany to this change in the plasma, and the achievement of euthyroidism led an improvement in these parameters.

TL;DR: Melatonin administration prior to ethanol did not alter MDA and GSH levels of tissue and among antioxidant defence enzymes studied, only CuZn-SOD was found to be increased in animals that received melatonin + ethanol.

TL;DR: The cost-of-illness method, in particular, the human-capital approach, is used to estimate the prevalence-based economic costs of alcohol abuse, consistent with international guidelines formulated at the 1994 International Symposium on Economic and Social Costs of Substance Abuse.

TL;DR: It was concluded that oxygen radicals are involved in the killing of bacteria and that there is endogenous formation of toxic oxygen products by mycotoxins.

TL;DR: The results indicate that diabetes, irrespective of associated hypertension, can cause major changes in cardiac performance and susceptibility to ischaemia and reperfusion.

TL;DR: Significant increases were found in lipid peroxidation (MDA+4-DHA) levels related to the duration of inhalation and significant decreases in superoxide dismutase activities and glutathione levels were observed from the third inhalation week to the end of the fifth week.

TL;DR: It was demonstrated that the lethal effect of MPTP was also partly protected by the chronic Nicotine treatment, and the chronic nicotine treatment also significantly protected MPTP-depressed spontaneous locomotor activity in mice.

TL;DR: The possible involvement of adenosine 5'-triphosphate (ATP) receptors in the function of the hippocampus is reviewed and the possibility that ATP protects brain function from over stimulation is discussed.

TL;DR: Results provide a molecular rationale to explain the spasmolytic action exerted by OB on intestinal smooth muscle and a combination of antimuscarinic and Ca2+ channel blocker properties seems to best account for the action of this compound.

TL;DR: It is suggested thatRadioiodine could facilitate or induce significant oxidant/antioxidant changes in erythrocytes-indirectly as a result of the internal radiotherapy with radioiodine.

TL;DR: Investigation of endothelial-derived reactive oxygen species and their interaction with nitric oxide during norepinephrine-induced contraction of rat aortic rings indicated the involvement of endothelium-derived hydrogen peroxide, superoxide and hydroxyl radicals in the NE-induced contractions.

TL;DR: Data demonstrate that NSAIDs could enhance the protective activity of antiepileptics, however, in case of valproate it may be associated with the severe side effects.

TL;DR: Despite clinically satisfactory ACE inhibition, circulating angiotensin II and aldosterone levels were still elevated in some patients, suggesting ald testosterone escape, and the between-visit agreement of plasma concentrations measured in duplicate was less than 35% for all circulating factors, except renin which showed a higher variability throughout the 3-week study period.

TL;DR: Protopine exhibits anti-hepatotoxic action which may be mediated through inhibition of MDME, suggestive of an inhibitory effect on MDME.