Showing papers in "Progress in Lipid Research in 2001"

TL;DR: The effects of CLA on body composition and growth/feed efficiency appear to be due to separate biochemical mechanisms, and it is shown that a 19-carbon CLA cognate inhibits lipoprotein lipase activity as effectively as CLA in cultured 3T3-L1 adipocytes.

TL;DR: In vivo studies using transgenic and knockout mice suggest that SREBP-1 seems to be involved in energy metabolism including fatty acid and glucose/insulin metabolism, whereas S REBP-2 is specific to cholesterol synthesis, and three isoforms, SRE BP-1a-1c, and have different roles in lipid synthesis.

TL;DR: A novel mechanism for proton leakage through lipid bilayers is proposed and a structure-function rationale for distinguishing the structures of the phytosterols as inhibitors of proton leaks from that of cholesterol which is proposed to inhibit leaks of Na(+).

TL;DR: The site of action of isoniazid, used in the treatment of tuberculosis for 50 years, and the consumer antimicrobial agent triclosan were revealed recently to be the enoyl-ACP reductase of the type II FAS, which contrasts sharply with the type I FAS of eukaryotes.

TL;DR: Although the 13 kDa SCP-2 is the most studied of these proteins, because it exhibits diversity of its ligand partners, new potential physiological function(s) are still being proposed and questions regarding potential compensation by other proteins with overlapping specificity are only beginning to be resolved.

TL;DR: This review focuses on the relationship between dietary polyunsaturated fatty acids and bone biology, both in vivo and in vitro.

TL;DR: The roles of peroxisome proliferator-activated receptors gamma and delta in the control of preadipocyte proliferation and differentiation during adipose tissue development or during the adaptive response of adipose tissues mass to high-fat feeding are reviewed.

TL;DR: The mechanism of alpha-oxidation as well as the enzymes involved in the process have been elucidated and several of the inborn errors involving phytanic acid and/or pristanic acid metabolism have been characterized on the molecular level.

TL;DR: The increased oxidation of fatty acids "drains" fatty acids from the body, reduces VLDL formation, and ultimately explains the antiadiposity and improved insulin sensitivity observed after administration of peroxisome proliferators.

TL;DR: Evidence is presented indicating that, although size is an important parameter, it is not decisive in determining access of liposomes to the hepatocytes, and the existence of at least four different mechanisms of interaction ofliposomes with hepatocytes is postulated.

TL;DR: A general overview of the methods involved in producing scintigraphic images as well as methods of radiolabeling liposomes is provided.