Showing papers in "Science in 1942"

The milk-influence of breast tumors in mice.

Abstract: Females of the fostered C3H strain and the BAF1 hybrid generation, having a normal incidence of breast tumors of 1-2 per cent., were given, by mouth or injection, filtrates (Seitz filter) or extracts of glycerinated-treated tissue containing the active milk-influence for the development of spontaneous breast cancer. Sixty-three experimental mice were observed to have an incidence of 41 per cent. Thirty-six mice received unfiltered or untreated material and have had an incidence of 67 per cent. Many of the mice of each group are still living. Previous studies indicated that the active milk-influence would not become inactive following desiccation.4 Following ultracentrifugation the active influence appeared in traces, if at all, in the fat fraction and in the final supernatant fluid, and it is possible that the active agent is a colloid of high molecular weight.5

Life in the andes and chronic mountain sickness.

Abstract: LowTemperature Physics in the USSR: P~olmssop. duced by Peptic Digestion of Proteins: PRoiFssoR Low Tbemperatubre UJSSR£: PoROFSSOR H. CROxERTO and DR. R. CROXATTO. In Vitro GuiC. T. LANE . . . . . . . 84 tivation of the Street Virus of Babies: LIEUTENANT The National Roster of Scientific and Specialized PerCOLONEL HARRY PLOTz and REGINALD REAGAN. sonnel: DR. LEONARD CARMICHAEL .......................... 86 Mechanism of P-Aminobenzoic Acid Action and the Parallel Effects of Ethyl Carbamate (Urethane): Obituary:. PROFESSOR FRANK H. JOHNSON ............ ............. 101 Elsie Clews Parsons: PROFESSOR FRANZ BoAs. Deaths and Memorials .................. ................... 89 Scientific pparat and Laboratory Methods: A Head Holder for Intracranial Operations on the Scientific Events: Monkey: DR. LINDSAY E. BEATON and DR. H. W. Adjustments in the Educational Program at the MAGOUN. Sodium Diphenylhydantoinate and ExMassachusetts Institute of Technology; The Finlay perimental Epilepsy: DR. H. MOUSSATCHt .................. 105 Institute of the Americas; The Genetics Society Science News . .. 8 of America; The Western Society of Naturalists; The Period of Internships in New York City; Award of the Copley Medal of the Royal Society 90 Scientific Notes and News .............. ......................... 93 SCIENCE: A Weekly Journal devoted to the AdvanceDiscussion: ment of Science, edited by J. MCKEzN CATTELL and pubNature of Group Theory: PROFESSOR G. A. MILLER lished every Friday by The Status of Experimental Psychology Among the THE SCIENCE PRESS Laboratory Sciences: DR. JOHN E. WINTER. A Pliocene Water-Hole in Western Kansas: GEORGE Lancaster, Pa. Garrison, N. Y. F. STERNBERG and DR. GEORGE M. ROBERTSON. The Case of Dr. S. Levine: PROFESSOR E. F. BURTON ....... 96 New York City: Grand Central Terminal Scientific Books: Annual Subscription, $6.00 Single Copies, 15 Cts. Medical Genetics: DR. CHAS. B. DAVENPORT ............ 99 SCIENCE is the official organ of the American AssociaReports: tion for the Advancement of Science. Information regardAnnual *eview of Activities at the Field Museum ing membership in the Association may be secured from Revie of Activities at the Musseu~m the office of the permanent secretary in the Smithsonian for 1941: CLIFFORD C. GREGG................ 100 Institution Building, Washington, D. C.

A simplified procedure for the concentration and purification of influenza virus.

Abstract: Objectives Accurate measurement of syndesmophyte development and growth in ankylosing spondylitis (AS) is needed for studies of biomarkers and of treatments to slow spinal fusion. We tested the longitudinal validity and sensitivity to change of quantitative measurement of syndesmophytes using CT. Methods We performed lumbar spine CT scans on 33 patients with AS at baseline, 1 year and 2 years. Volumes and heights of syndesmophytes were computed in four intervertebral disk spaces. We compared the computed changes to a physician9s ratings of change based on CT scan inspection. Sensitivity to change of the computed measures was compared with that of the modified Stoke AS Spinal Score (radiography) and a scoring method based on MRI. Results At years 1 and 2, respectively 24 (73%) and 26 (79%) patients had syndesmophyte volume increases by CT. At years 1 and 2, the mean (SD) computed volume increases per patient were, respectively 87 (186) and 201 (366) mm3. Computed volume changes were strongly associated with the physician9s visual ratings of change (p Conclusions CT-based syndesmophytes measurements had very good longitudinal validity and better sensitivity to change than radiography or MRI. This method shows promise for longitudinal clinical studies of syndesmophyte development and growth.