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262. FSH and LH content of plasma after mitomycin treatment and the effect of the antibiotic on ovarian cellular constituents

C. Deb, Majumdar G, K. Ghosh, R. Mukherjee, Bagchi P 
01 Sep 1978-Journal of Steroid Biochemistry-Vol. 9, Iss: 9, pp 867
About: This article is published in Journal of Steroid Biochemistry.The article was published on 1978-09-01. It has received 1 citations till now.
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TL;DR: Mitomycin C (MC), an antibiotic which depresses DNA synthesis causes suppression of enzyme delta 5 3 beta-hydroxysteroid dehydrogenase and glucose-6 phosphate dehydration in the rat adrenal tissue, suggesting a diminution in adrenal steroid biogenesis similar to gonadal inhibition previously reported.
Abstract: Mitomycin C (MC), an antibiotic which depresses DNA synthesis causes suppression of enzyme delta 5 3 beta-hydroxysteroid dehydrogenase (delta 5 3 beta OHD) and glucose-6 phosphate dehydrogenase (G-6 PD) in the rat adrenal tissue. The treatment resulted in a fall in DNA content together with an accumulation of cholesterol and ascorbic acid in the gland. The results suggest a diminution in adrenal steroid biogenesis similar to gonadal inhibition previously reported.

3 citations


Cites background from "262. FSH and LH content of plasma a..."

  • ...The same drug is also reported tv cause a diminution in ovarian steroid biogenesis, as evidenced by several experimental evidences (3)....

    [...]

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Journal Article
TL;DR: Mitomycin C (MC), an antibiotic which depresses DNA synthesis causes suppression of enzyme delta 5 3 beta-hydroxysteroid dehydrogenase and glucose-6 phosphate dehydration in the rat adrenal tissue, suggesting a diminution in adrenal steroid biogenesis similar to gonadal inhibition previously reported.
Abstract: Mitomycin C (MC), an antibiotic which depresses DNA synthesis causes suppression of enzyme delta 5 3 beta-hydroxysteroid dehydrogenase (delta 5 3 beta OHD) and glucose-6 phosphate dehydrogenase (G-6 PD) in the rat adrenal tissue. The treatment resulted in a fall in DNA content together with an accumulation of cholesterol and ascorbic acid in the gland. The results suggest a diminution in adrenal steroid biogenesis similar to gonadal inhibition previously reported.

3 citations