Journal ArticleDOI
A chiral total synthesis of compactin
Masahiro Hirama,Mitsuko Uei +1 more
About:
This article is published in Journal of the American Chemical Society.The article was published on 1982-07-01. It has received 94 citations till now. The article focuses on the topics: Total synthesis.read more
Citations
More filters
Journal ArticleDOI
Chemistry and Biology of Mycotoxins and Related Fungal Metabolites
Journal ArticleDOI
Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs
Matilde Manzoni,Manuela Rollini +1 more
TL;DR: The use of statins can lead to a reduction in coronary events related to hypercholesterolemia, but the relationship between benefit and risk, and any possible interaction with other drugs, must be taken into account.
Journal ArticleDOI
Synthesis of chiral pharmaceutical intermediates by biocatalysis
TL;DR: Chiral intermediates were prepared by biocatalytic processes for the chemical synthesis of four pharmaceutical drug candidates and served as intermediates for thromboxane A2 antagonist.
Journal ArticleDOI
Microbial Asymmetric Catalysis—Enantioselective Reduction of Ketones [New Synthetic Methods (45)]
Charles J. Sih,Ching-Shih Chen +1 more
TL;DR: The present progress report deals with the basic concepts that govern enantioselectivity of enzymes and intact cells and strategies to control the stereochemical course of microbial reductions of carbonyl compounds and the relationship of substrate structure to enantiOSElectivity.