A human major histocompatibility complex class i gene that encodes a protein with a shortened cytoplasmic segment
Reads0
Chats0
TLDR
Structural features of HLA-6.0 suggest that this non-HLA-A, -B, -C gene is a structural homolog of a murine Qa region class I gene, as well as other cloned genomic DNA encoding genes located within a HindIII-generated restriction fragment of 6.0 kilobase pairs.Abstract:
We have cloned genomic DNA encoding a non-HLA-A, -B, -C class I gene located within a HindIII-generated restriction fragment of 6.0 kilobase pairs. This gene, designated HLA-6.0, is as homologous to HLA-A and HLA-B as they are to each other. The HLA class I protein encoded by HLA-6.0 is similar in organization to the HLA-A-, -B-, and -C-encoded proteins except that an in-frame termination codon prevents translation of a majority of the cytoplasmic region of the HLA-6.0 polypeptide. Moreover, the promoter region of HLA-6.0 resembles the promoter region of a Qa region gene. These structural features of HLA-6.0 suggest that this non-HLA-A, -B, -C gene is a structural homolog of a murine Qa region class I gene.read more
Citations
More filters
Journal ArticleDOI
A class I antigen, HLA-G, expressed in human trophoblasts.
Susan Kovats,Elliott K. Main,Clifford Librach,Marcia Stubblebine,Susan J. Fisher,Robert DeMars +5 more
TL;DR: HLA-G is subject to both cell type-specific and developmental regulation and is expressed in early gestation human cytotrophoblasts and is present in choriocarcinoma cell lines studied.
Journal ArticleDOI
Protection from natural killer cell-mediated lysis by HLA-G expression on target cells
Laszlo Pazmany,Ofer Mandelboim,Mar Valés-Gómez,Daniel M. Davis,Hugh T. Reyburn,Jack L. Strominger +5 more
TL;DR: Evidence is provided that expression of HLA-G is sufficient to protect otherwise susceptible target cells from lysis by activated NK1 and NK2 cell lines and clones that are specific for distinct groups of Hla-C alleles.
Journal ArticleDOI
Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens.
TL;DR: It is demonstrated that the HLA-G primary transcript is alternatively spliced to yield at least three distinct mature mRNAs, and the largest mRNA is essentially that previously characterized, encoding a leader sequence, three external domains, a transmembrane region, and a cytoplasmic sequence.
Journal ArticleDOI
Cell-cell adhesion mediated by CD8 and MHC class I molecules.
TL;DR: A cell-cell binding assay is developed that measures adhesion of human B-cell lines expressing MHC class I molecules to transfected cells expressing high levels of human CDS, showing that CDS directly binds to MHCclass I molecules.
Journal ArticleDOI
Cutting edge: soluble HLA-G1 triggers CD95/CD95 ligand-mediated apoptosis in activated CD8+ cells by interacting with CD8.
Sylvie Fournel,Maryse Aguerre-Girr,Xavier Huc,Françoise Lenfant,Antoine Alam,Antoine Toubert,Armand Bensussan,Philippe Le Bouteiller +7 more
TL;DR: It is shown that sHLA-G1-induced apoptosis depends on the interaction with CD8 molecules, with cell death being blocked by various CD8 mAbs, and that apoptosis is mediated through the CD95/CD95 ligand pathway.