Journal ArticleDOI
A hypothesis for chemical carcinogen induced chromatin condensation
TLDR
A hypothesis for chemical carcinogen induced condensation of nuclear and nucleolar chromatin is proposed and it is believed to be a result of cascade effects initiated by the inhibition of messenger RNA synthesis after exposure tochemical carcinogen in vivo.Abstract:
A hypothesis for chemical carcinogen induced condensation of nuclear and nucleolar chromatin is proposed. Chromatin condensation is believed to be a result of cascade effects initiated by the inhibition of messenger RNA synthesis after exposure to chemical carcinogen in vivo. Inhibition of messenger RNA synthesis leads to the loss of protein production, which in turn causes the dephosphorylation of histone H1 and triggers the condensation of chromatin in vivo.read more
Citations
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Journal ArticleDOI
The Effects of DNA Covalent Adducts on in Vitro Transcription.
Marek Gniazdowski,Cinzia Cera +1 more
Journal ArticleDOI
DNA Content and Chromatin Texture of Benzo[a]pyrene-Transformed Human Breast Epithelial Cells as Assessed by Image Analysis☆
TL;DR: The results indicate loss of DNA and a change in chromatin higher order packing states accompanying the expression of different stages of the in vitro tumorigenesis process in BP-transformed human breast epithelial cells.
Journal ArticleDOI
Preferential in vivo DNA repair of melphalan-induced damage in human genes is greatly affected by the local chromatin structure
Vassilis L. Souliotis,Meletios A. Dimopoulos,Hara Episkopou,Soterios A. Kyrtopoulos,Petros P. Sfikakis +4 more
TL;DR: The in vivo gene-specific repair of melphalan-induced damage in humans is greatly affected by the local chromatin structure, suggesting that transcription and/or Chromatin structure may play important roles in the preferential DNA repair.
Journal ArticleDOI
Prevention of chemical carcinogen DNA binding and inhibition of nuclear RNA polymerase activity by organosulfur compounds as the possible mechanisms for their anticancer initiation and proliferation effects.
TL;DR: DADS and DATS, but not DAS, could be activated by the versatile epoxide-forming oxidant dimethyldioxirane (DMDO) and could strongly inhibit nuclear RNA synthesis in vitro and were able to directly inhibit the enzyme RNA polymerase per se.
Dissertation
Mobility and distribution of proteins in the nucleus of living cells
TL;DR: It is shown that the short peptide with ten amino acids was able to cross cellular membranes and reach the nucleolar target sites, thereby marking this subnuclear structure in living cells.