Journal ArticleDOI
A new method for evaluating antitussive medications using the citric acid challenge technique.
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This article is published in The Journal of new drugs.The article was published on 1965-03-04. It has received 5 citations till now. The article focuses on the topics: Antitussive Agent.read more
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Journal Article
Codeine and its alternates for pain and cough relief: 3. The antitussive action of codeine—mechanism, methodology and evaluation
TL;DR: This report-the third of a series on codeine and its alternates for pain and cough relief-presents a detailed review of the physiology and pathophysiology of cough, the methods for the experimental and clinical measurement of the antitussive action of drugs, possible mechanisms of action of antitussives agents, and includes a compilation of experimental results and clinical experience with codeine as an antitussIVE.
Journal ArticleDOI
Assessment of antitussive effects by citric acid threshold
P. J. Rees,T. J. H. Clark +1 more
TL;DR: It is concluded that the citric acid threshold is a simple measure of antitussive activity and no such activity was found with glaucine.
Journal ArticleDOI
Latency of cough response as a measure of antitussive agents.
TL;DR: The cough reflex was stimulated in selected healthy male subjects with a single nebulized threshold dose of citric acid and a dose‐response curve was obtained for codeine and dextromethorphan.
Journal ArticleDOI
Irritant induced cough as a model of intrapulmonary airway reactivity
T. P. Clay,M. A. Thompson +1 more
TL;DR: It is suggested that the reactivity of intrapulmonary airway smooth muscle dictates the cough response following inhalation of a citric acid mist.
Journal ArticleDOI
Preclinical and Clinical Investigation of Drugs II. Antitussive Drugs
Harry Salem,Domingo M. Aviado +1 more
TL;DR: A review of the literature on antitussives has revealed a series of observations which are not in conformity with the above simple thesis of an action of antitussive drugs on the central nervous system (CNS).
References
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Journal ArticleDOI
Objective assessment of cough suppressants under clinical conditions using a tape recorder system.
C. R. Woolf,A. Rosenberg +1 more
TL;DR: A technique which employs the objectivity of cough counting to determine the effect of suppressants on pathological cough is described and levo-propoxyphene,' elixir of terpin hydrate with heroin, and syrup of codeine have been assessed.
Journal ArticleDOI
The cough response of healthy human subjects stimulated by citric acid aerosol. II. Evaluation of antitussive agents.
Journal ArticleDOI
Evaluation of a New Antitussive Agent
Leo J. Cass,Willem S. Frederik +1 more
TL;DR: A study was undertaken to determine the antitussive effect of this substance clinically, and it was found that the analgesic action of racemorphan resides in its levorotatory component.