Journal ArticleDOI
A novel dealkylation affording 3-aminoimidazo[1,2-a]pyridines: access to new substitution patterns by solid-phase synthesis†
Christopher Blackburn,Bing Guan +1 more
TLDR
In this paper, the acid-induced dealkyation reaction was used to remove the 1,1,3,3-tetramethylbutyl group derived from the isonitrile input.About:
This article is published in Tetrahedron Letters.The article was published on 2000-03-04. It has received 77 citations till now. The article focuses on the topics: Alkylation & Pyridine.read more
Citations
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Journal ArticleDOI
Multicomponent Reactions with Isocyanides.
Alexander Dömling,Ivar Ugi +1 more
TL;DR: MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures, however, this requires that the chemist learns the "language" of M CRs, something that this review wishes to stimulate.
Journal ArticleDOI
Recent Developments in the Isonitrile‐Based Multicomponent Synthesis of Heterocycles
TL;DR: A review of isocyanide-based multicomponent reactions for heterocycle synthesis can be found in this paper, where the authors advocate a "substrate-design approach" in searching for novel MCRs.
Journal ArticleDOI
Recent advances in the synthesis of (hetero)aryl-substituted heteroarenes via transition metal-catalysed direct (hetero)arylation of heteroarene C–H bonds with aryl halides or pseudohalides, diaryliodonium salts, and potassium aryltrifluoroborates
Fabio Bellina,Renzo Rossi +1 more
Journal ArticleDOI
Multikomponentenreaktionen mit Isocyaniden
Alexander Dömling,Ivar Ugi +1 more
TL;DR: Multikomponentenreaktionen (MCRs) unterscheiden sich in mehreren Aspekten grundlegend von Zweik-componenten reaktionsen.
Journal ArticleDOI
To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis
Mariateresa Giustiniano,Andrea Basso,Valentina Mercalli,Alberto Massarotti,Ettore Novellino,Gian Cesare Tron,Jieping Zhu +6 more
TL;DR: All the isocyanides in which the pendant functional group causes either deviation from or reinforces the normal reactivity of the isOCyano group are reviewed and categorized to highlight their common features and differences.
References
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Journal ArticleDOI
Multicomponent reactions in organic-chemistry
TL;DR: In this paper, it has been shown that effective syntheses can be carried out using three, or sometimes more, reactants simultaneously and a few such processes are used industrially.
Journal ArticleDOI
Synthesis of Imidazo[1,2-a] annulated Pyridines, Pyrazines and Pyrimidines by a Novel Three-Component Condensation
Journal ArticleDOI
Parallel synthesis of 3-aminoimidazo[1,2-a]pyridines and pyrazines by a new three-component condensation
TL;DR: A three-component condensation reaction between 2-aminopyridine, an aldehyde and an isonitrile catalyzed by scandium triflate affords derivatives of 3-aminoimidazo[1,2-a]pyridine; aminopyrazine reacts similarly.
Journal ArticleDOI
Synthesis and antibacterial activity of some imidazo[1,2-a]pyrimidine derivatives.
TL;DR: A series of 75 imidazo[1,2-a]pyrimidine derivatives were synthesized and exhibited potent antimicrobial activity against a variety of gram (+, gram (-) bacteria and Mycobacteria species.
Journal ArticleDOI
Use of solid supported nucleophiles and electrophiles for the purification of non-peptide small molecule libraries
TL;DR: Solid supported nucleophiles and electrophiles are employed to expedite the work-up and purification of a variety of amine alkylations acylacylations, particularly advantageous for the construction of non-peptide libraries in a parallel array format.
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