Journal ArticleDOI
A Randomized, Double-Blind, Multicenter Comparison of the Efficacy and Tolerability of Restylane Versus Zyplast for the Correction of Nasolabial Folds
Rhoda S. Narins,Fredric S Brandt,James J. Leyden,Z. Paul Lorenc,Mark A. Rubin,Stacy R. Smith +5 more
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TLDR
Patients and investigators judged hyaluronic acid gel to be more effective in maintaining cosmetic correction and nonanimal stabilized hyaluonic acid provides a more durable aesthetic improvement than bovine collagen and is well tolerated.Abstract:
Background Bovine collagen is extensively used for facial soft tissue augmentation but provides only temporary correction and can cause hypersensitivity reactions. Hyaluronic acid derivatives potentially offer improved longevity of correction and a reduced risk of immunogenicity and hypersensitivity. Objective To compare the efficacy and safety of nonanimal stabilized hyaluronic acid gel (Restylane; Q-Med, Uppsala, Sweden) with that of bovine collagen (Zyplast) for treatment of nasolabial folds. Methods One hundred thirty-eight patients with prominent nasolabial folds were randomized to treatment with hyaluronic acid gel and bovine collagen on contralateral sides of the face. Treatments were repeated at 2-week intervals, as required, to achieve "optimal cosmetic result" (baseline). Outcomes were evaluated by a blinded investigator at 2, 4, and 6 months after baseline. Results Less injection volume was required for "optimal cosmetic result" with hyaluronic acid gel than with bovine collagen, and patients and investigators judged hyaluronic acid gel to be more effective in maintaining cosmetic correction. The investigator-based Wrinkle Severity Rating Scale and Global Aesthetic Improvement Scale assessments at 6 months after baseline indicated that hyaluronic acid gel was superior in 56.9% and 62.0% of patients, respectively, whereas bovine collagen was superior in 9.5% and 8.0% of patients, respectively. The frequency, intensity, and duration of local injection-site reactions were similar for the two products. Conclusion Nonanimal stabilized hyaluronic acid provides a more durable aesthetic improvement than bovine collagen and is well tolerated.read more
Citations
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Journal ArticleDOI
Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications.
TL;DR: An overview of the occurrence and physiological properties of HA, as well as of the recent advances in production biotechnology and preparation of the HA-based materials for medical application are presented.
Journal ArticleDOI
Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications
TL;DR: The purpose of this paper is to review the various chemical modification methods and synthetic routes to obtain HA derivatives, encompassing all applications.
Journal ArticleDOI
Photoaging: Mechanisms and repair
TL;DR: The focus of this review is the mechanism of photoaging and the pathophysiology underlying the treatments specifically designed for its prevention and treatment.
Journal ArticleDOI
Comparative Physical Properties of Hyaluronic Acid Dermal Fillers
TL;DR: Combining the objective factors that influence filler performance with clinical experience will provide the patient with the optimal product for achieving the best cosmetic result.
Journal ArticleDOI
In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin
Frank Wang,Luis A. Garza,Luis A. Garza,Sewon Kang,James Varani,Jeffrey S. Orringer,Gary J. Fisher,John J. Voorhees +7 more
TL;DR: It is hypothesized that this stimulatory effect may be induced by mechanical stretching of the dermis, which in turn leads to stretching and activation of dermal fibroblasts, and may be useful for stimulating collagen production therapeutically, particularly in the setting of atrophic skin conditions.
References
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Journal ArticleDOI
Injectable Hyaluronic Acid Gel for Soft Tissue Augmentation: A Clinical and Histological Study
TL;DR: Stabilized, non‐animal, hyaluronic acid gel is well tolerated and effective in augmentation therapy of soft tissues of the face and expands the arsenal of therapeutic tools in the field of soft tissue augmentation.
Journal ArticleDOI
Safety data of injectable nonanimal stabilized hyaluronic acid gel for soft tissue augmentation.
TL;DR: According to the reported worldwide adverse events data, hypersensitivity to nonanimal hyaluronic acid gel is the major adverse event and is most likely secondary to impurities of bacterial fermentation.
Journal ArticleDOI
Injectable collagen for soft tissue augmentation.
Knapp Tr,Kaplan En,Daniels +2 more
TL;DR: This work has treated 28 patients with human and/or bovine collagen injections for the correction of soft tissue contour defects, and they have followed them for 3 to 18 months.
Journal ArticleDOI
The first clinical study using a new biodegradable implant for the treatment of lips, wrinkles, and folds.
TL;DR: A new tissue augmentation product, made from hyaluronic acid, was clinically evaluated at three clinics in accordance with the new directive, EN 540, for medical implants, and showed that close to 60% of the effect was still there at 12 months follow-up.
Journal ArticleDOI
Hylan gel biomaterial: dermal and immunologic compatibility.
TL;DR: Hylan gel was injected intradermally and subdermally in mice and was found to produce a minimal reaction at 24 h; thereafter, there was no significant tissue reaction; and serum from owl monkeys contained no detectable anti-hylan gel antibodies (PCA assay).