A review of bone marrow lesions in the arthritic knee and description of a technique for treatment
Alberto Gobbi,Ignacio Dallo,Rachel M. Frank,Hannah Bradsell,Ivan Saenz,William Murrel +5 more
- Vol. 1, Iss: 3, pp 100021
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TLDR
The use of novel biologic techniques to treat BMLs in the knee, such as PRP and Bone Marrow Cells, has yielded promising clinical outcomes and a need for high-quality RCTs studies and systematic reviews in the future to enhance further treatment strategy.Abstract:
Introduction Subchondral bone pathology includes a wide range of pathologies, such as osteoarthritis, spontaneous insufficiency fractures, osteonecrosis, transient bone marrow lesions syndromes, and trauma. They show typical magnetic resonance imaging (MRI) findings termed bone marrow lesions (BMLs). However, the etiology and evolution of BMLs in multiple conditions remains unclear. There is still no gold standard treatment protocol in treating BMLs in the knee, and a variety of treatment modalities have been tested in the hope that they might reduce pain and stop disease progression. Objectives To review the treatment options for BMLs of the knee. Methods A literature review was performed that included searches of PubMed, Cochrane, and Medline databases using the following keywords: Bone marrow lesions, sub chondroplasty, bone marrow concentrate, platelet-rich plasma (PRP), subchondral bone augmentation. Results The use of novel biologic techniques to treat BMLs in the knee, such as PRP and Bone Marrow Cells, has yielded promising clinical outcomes. Conclusions Future research of BMLs will be mandatory to address the different pathologies better and determining appropriate treatment strategies. There is still a need for high-quality RCTs studies and systematic reviews in the future to enhance further treatment strategy in preventing or treating BMLs of the knee.read more
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Mesenchymal stem cells for subchondral bone marrow lesions: From bench to bedside
Rosa M. Pasculli,Charles D. Kenyon,William A. Berrigan,Kenneth Mautner,Kyle E. Hammond,Prathap Jayaram +5 more
TL;DR: In this article , mesenchymal stem cells (MSCs) were used to treat bone marrow lesion in patients with knee osteoarthritis and avascular necrosis.
Journal ArticleDOI
Minimally invasive cell-based therapy for symptomatic bone marrow lesions of the knee: A prospective clinical study at 1 year.
TL;DR: Preliminary results confirm that biological subchondral bone augmentation by Osteo Core Plasty technique is a safe and effective minimally invasive treatment option for symptomatic BMLs in the knee at 1-year follow-up.
Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors
TL;DR: The identification, isolation, and characterization of these human blood-vessel-derived stem cells (hBVSCs) are discussed and the current status of regenerative applications of hBV SC subsets is summarized.
Journal ArticleDOI
Welcome to the third issue of JCJP
TL;DR: This issue of the Journal of Joint Preservation and Cartilage Restoration (JCJP), the official journal of the International Cartilage Regeneration & Joint Preservation Society (ICRS), has several outstanding articles from thought leaders in joint preservation from around the globe.
Posted ContentDOI
Comparison of Evaluation Metrics of Deep Learning for Imbalanced Imaging Data in Osteoarthritis Studies
Frank W. Roemer,Yong Ge,Edward J. Bedrick,Ali Guermazi,Leena Sharma,Charles Eaton,Marc C. Hochberg,David J. Hunter,Michael C. Nevitt,Wolfgang Wirth,C. Kent Kwoh,Xiaoxiao Sun +11 more
TL;DR: It is demonstrated that the commonly used ROC curve is not sufficiently informative when evaluating the performance of deep learning models in the imbalanced data in OA studies.
References
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Early irreversible osteonecrosis versus transient lesions of the femoral condyles: prognostic value of subchondral bone and marrow changes on MR imaging.
Frédéric Lecouvet,B C van de Berg,Baudouin Maldague,C. Lebon,Jacques Jamart,M Saleh,H. Noel,Jacques Malghem +7 more
TL;DR: Careful assessment of MR imaging changes occurring in the subchondral area can enable confident differentiation between transient epiphyseal lesions and early irreversible osteonecrosis of the femoral condyle.
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Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis: Preliminary Results in a Group of Active Patients
TL;DR: The PRP treatment showed positive effects in patients with knee OA and both operated and nonoperated patients showed significant improvement by means of diminishing pain and improved symptoms and quality of life.
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The vascularity and remodelling of subchondrial bone and calcified cartilage in adult human femoral and humeral heads. An age- and stress-related phenomenon
TL;DR: The degree of active remodelling by endochondral ossification declined from adolescence until the seventh decade in the femoral head, and 30% until the sixth century in the humeral head, rising thereafter to levels comparable to those found at young ages.
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Knee Osteoarthritis: A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations.
Dragan Primorac,Vilim Molnar,Eduard Rod,Željko Jeleč,Fabijan Čukelj,Vid Matišić,Trpimir Vrdoljak,Damir Hudetz,Hana Hajsok,Igor Borić +9 more
TL;DR: All of the latest and most important research in basic sciences, pathogenesis, and non-operative treatment of osteoarthritis is summarized.
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Bone bruises associated with ACL rupture: correlation with injury mechanism.
TL;DR: The noncontact mechanism appears to cause more severe bone bruising in both the medial and lateral compartments, particularly in the noncontact group.