Open AccessJournal Article
Action of caerulein on gastric emptying of the conscious rat.
TLDR
The present study emphasizes the close parallelism between results obtained in the in situ stomach preparation of anaesthetized rats and gastric emptying in conscious animals.Abstract:
Caerulein was shown to delay gastric emptying in conscious rats in a dose-dependent fashion. The threshold dose was about 0.05 mug/kg by the intraperitoneal route. Maximum effect was obtained with 5 mug/kg. Neutralization of acidity or reduction of gastric juice by mean of NaHCO3 or cimetidine, respectively, did not modify the effect of the peptide. Chlorpheniramine was similarly ineffective. The effect of caerulein on gastric emptying was most probably connected with a strong contraction of the gastroduodenal junction previously observed in different experimental conditions and was not affected by H1- or H2-histamine antagonists. The C-terminal heptapeptide of cholecystokinin behaved quite similarly to caerulein. The present study emphasizes the close parallelism between results obtained in the in situ stomach preparation of anaesthetized rats and gastric emptying in conscious animals.read more
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Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms
Neşe I˙meryüz,Berrak Ç. Yeğen,Ayhan Bozkurt,Tamer Coskun,Maria L. Villanueva-Peñacarrillo,N.B. Ulusoy +5 more
TL;DR: In gastric fistula rats, vagal afferent denervation and peripheral administration of the GLP-1 receptor antagonist exendin enhanced emptying of a glucose meal, whereas intracerebroventricularExendin was ineffective, and the notion that GLP1 receptors participate in the central and peripheral regulation of gastric function is supported.
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Methods for regulating gastrointestinal motility
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Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of amylin
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Dose-responses for the slowing of gastric emptying in a rodent model by glucagon-like peptide (7-36) NH2, amylin, cholecystokinin, and other possible regulators of nutrient uptake.
TL;DR: The potencies of subcutaneously preinjected amylin, glucagon-like peptide-1 (7-36)amide (GLP-1), cholecystokinin octapeptide (CCK-8), gastric inhibitory peptide (GIP), glucagon, and pancreatic peptide on slowing the release of an acaloric gel from rat stomach were compared.
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Gastric stasis in neuronal nitric oxide synthase-deficient knockout mice.
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