Acute toxicity study of 5, 11 dihydroindolo [3, 2-ß] carbazole as per OECD regulatory guidelines.

TLDR: Based on findings of the current investigation, 5, 11 dihydroindolo [3, 2-ß] carbazole is safe phytoconstituent of Arisaema genus which can be explored for various biological activities.

Abstract: BACKGROUND 5, 11 dihydroindolo [3, 2-ß] carbazole is one of the phytoconstituent of Arisaema genus which might have various important biological activities. Recently, we have also predicted antiviral potential of this phytoconstituent against Japanese Encephalitis virus (JEV). METHODOLOGY Thus, in the current study, acute toxicity profile of 5, 11 dihydroindolo [3, 2-ß] carbazole as per OECD regulatory guidelines in female Wistar rats was evaluated. RESULTS We did not find any adverse effects, mortality, and altered behaviour in animals after administration of 5, 11 dihydroindolo [3, 2-ß] carbazole at a dose of 300 and 2000 mg/Kg. Further, no significant changes in physiological and haematological parameters were observed. The histopathological study of vital organs has also shown no significant changes as compared to control. CONCLUSION Based on findings of the current investigation, 5, 11 dihydroindolo [3, 2-ß] carbazole is safe phytoconstituent of Arisaema genus which can be explored for various biological activities.