Journal ArticleDOI
Natural chemical entities from Arisaema genus might be a promising break-through against Japanese encephalitis virus infection: a molecular docking and dynamics approach
TLDR
Virtual ligand screening (VLS) method is undertaken to screen out selected phytoconstituents of Genus Arisaema against various targets of JEVs which exhibits vital role in replication, infection cycle and host interaction by using molecular docking followed by molecular dynamics simulations.Abstract:
Japanese encephalitis virus (JEV) infection affects millions of population worldwide whose incidence is increasing year by year and currently, no specific drugs are available for its treatment. How...read more
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Journal Article
Estimated Global Incidence of Japanese Encephalitis: A Systematic review/Estimation De L'incidence Mondiale De L'encephalite Japonaise: Une Evaluation Systematique/ Incidencia Global Estimada De la Encefalitis Japonesa: Una Revision Sistematica
Grant L. Campbell,Susan L. Hills,Marc Fischer,Julie Jacobson,Charles H. Hoke,Joachim Hombach,Anthony A. Marfin,Tom Solomon,Theodore F. Tsai,Vivien Tsu,Amy Sarah Ginsburg +10 more
TL;DR: In this paper, the authors present a review of Japanese encephalitis (JE) in Asia, focusing on rural and suburban areas where rice culture and pig farming coexist.
Journal ArticleDOI
Pathobiology of Japanese encephalitis virus infection.
TL;DR: A comprehensive review of the Japanese encephalitis virus life cycle and how the cellular stress responses dictate the pathobiology and resulting immune response is provided in this paper, where modulation of these stress pathways could be a potential strategy to develop therapeutic interventions, and define the persisting challenges.
Journal ArticleDOI
In silico and in vitro evaluation of efflux pumps inhibition of α,β-amyrin
Raissa C Oliveira,Paulo Nogueira Bandeira,Telma L. G. Lemos,Hélcio Silva dos Santos,Jackelyne Roberta Scherf,Janaína Esmeraldo Rocha,Raimundo Luiz Silva Pereira,Thiago Sampaio de Freitas,Priscila R. Freitas,Francisco N. Pereira-Junior,Márcia Machado Marinho,Emanuelle Machado Marinho,Emmanuel Silva Marinho,Carlos Emídio Sampaio Nogueira,Henrique Douglas Melo Coutinho,Alexandre Magno Rodrigues Teixeira +15 more
TL;DR: Sarma et al. as mentioned in this paper evaluated the antibacterial activity of α, β-amyrin mixture isolated from Protium heptaphyllum against the multidrug-resistant strains of Escherichia coli 06 and Staphylococcus aureus 10.
Journal ArticleDOI
Antiviral drug research for Japanese encephalitis: an updated review
TL;DR: In this paper , a literature search was performed using databases such as PubMed Central, Google Scholar, Wiley Online Library, etc. using keywords such as Japanese encephalitis virus, antivirus drugs, antiviral drug screening, and antivirus drug targets, whereas 180 most relevant and important ones have been cited.
Journal ArticleDOI
Antiviral drug research for Japanese encephalitis: an updated review
TL;DR: In this paper , a literature search was performed using databases such as PubMed Central, Google Scholar, Wiley Online Library, etc. using keywords such as Japanese encephalitis virus, antivirus drugs, antiviral drug screening, and antivirus drug targets, whereas 180 most relevant and important ones have been cited.
References
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Journal ArticleDOI
Estimated global incidence of Japanese encephalitis: a systematic review
Grant L. Campbell,Susan L. Hills,Marc Fischer,Julie Jacobson,Charles H. Hoke,Joachim Hombach,Anthony A. Marfin,Tom Solomon,Theodore F. Tsai,Vivien Tsu,Amy Sarah Ginsburg +10 more
TL;DR: The estimate of the global incidence of JE remains substantial despite improvements in vaccination coverage, and more and better incidence studies in selected countries, particularly China and India, are needed to further refine these estimates.
Journal ArticleDOI
An RNA cap (nucleoside‐2′‐O‐)‐methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization
TL;DR: The results provide a structural basis for the rational design of drugs against the emerging flaviviruses and suggest that the latter is a specific cap‐binding site.
Journal ArticleDOI
Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins.
TL;DR: This work constructed recombinant vaccinia viruses expressing various portions of the NS region of the dengue virus type 4 polyprotein and showed that NS2B was needed, apparently in cis, for NS3/NS4A cleavage and for a series of internal cleavages in NS3.
Journal Article
Estimated Global Incidence of Japanese Encephalitis: A Systematic review/Estimation De L'incidence Mondiale De L'encephalite Japonaise: Une Evaluation Systematique/ Incidencia Global Estimada De la Encefalitis Japonesa: Una Revision Sistematica
Grant L. Campbell,Susan L. Hills,Marc Fischer,Julie Jacobson,Charles H. Hoke,Joachim Hombach,Anthony A. Marfin,Tom Solomon,Theodore F. Tsai,Vivien Tsu,Amy Sarah Ginsburg +10 more
TL;DR: In this paper, the authors present a review of Japanese encephalitis (JE) in Asia, focusing on rural and suburban areas where rice culture and pig farming coexist.
Journal ArticleDOI
Determination of total phenolic and flavonoid content, antimicrobial and antioxidant activity of a root extract of Arisaema jacquemontii Blume
Shoib Ahmad Baba,Shahid A. Malik +1 more
TL;DR: In this paper, the authors evaluated the antioxidant and antimicrobial activity of a methanolic extract of the roots of Arisaema jacquemontii and determined the 1,1-diphenyl-2-picryl-hydrazyl (DPP...