Journal ArticleDOI
Adverse effect of clomiphene citrate on sperm morphology.
B. Shanis,Check Jh,A. Bollendorf +2 more
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TLDR
There was significant deterioration of sperm function as measured by percentage of normal forms in patients treated with CC for 4-18 months, and the physiological clinical significance remains to be investigated.Abstract:
The beneficial effect of clomiphene citrate (CC) in treating male infertility is controversial. To evaluate the effects of CC on sperm morphology using strict criteria, the semen analyses of 74 men were evaluated at intervals ranging from 1 to 18 months of treatment. Seventy patients receiving no medication were used as control. The patients in each category were divided into three subgroups: A (1–3 months), B (4–6 months), and C (>6 months). In the control group, there were no significant differences in percentages or total normal forms between baseline and repeat semen analysis at any interval. Treatment with CC for 1–3 months did not adversely affect percentages of normal forms. Treatment for greater than 3 months caused a highly significant decrease in percentage of normal forms. Three months of CC caused no change in the absolute number of morphologically normal sperm, but longer periods (>6 months) were associated with a significant decrease. There was significant deterioration of sperm function as ...read more
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Trans-clomiphene for metabolic syndrome
TL;DR: In this paper, the administration of compositions comprising an antiestrogen, preferably trans-clomiphene, for treating metabolic syndrome in a subject was described, and a method for reducing fasting glucose levels in the subject by administering a composition comprising anti-estrogens, or trans-lomiphenes, was proposed.
Journal ArticleDOI
A paradoxical decline in semen parameters in men treated with clomiphene citrate: A systematic review.
TL;DR: A systemic review using PubMed, Embase, Cochrane Library and Scopus databases for original studies reporting adverse effects of clomiphene citrate therapy on sperm parameters finds that in up to 17% of patients, deterioration of semen parameters did not recover following discontinuation of therapy.
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Dosing regimes for trans-clomiphene
TL;DR: In this article, the use of compositions comprising of ®Υww-clomiphene for treating men with hypogonadism and disorders related to them, including reduction of muscle mass, limitation of body performance capacity, reduction of bone density, and reduction of libido.
Journal ArticleDOI
Effect of Oral Administration of Clomiphene Citrate on Sperm Viability and Fertility of Boar Semen
TL;DR: It was observed that total semen volume, sperm motility, per cent live sperm, total sperm/ejaculate, sperm with normal apical ridge and serum testosterone levels improved with increasing levels of Clomiphene citrate.
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Trans-clomiphene metabolites and uses thereof
TL;DR: In this paper, substantially pure metabolites of irara-clomiphene have been used in the treatment of various disorders including secondary hypogonadism, type 2 diabetes, elevated cholesterol, elevated triglycerides, wasting, lipodystrophy, female and male infertility, benign prostate hypertrophy, prostate cancer, breast cancer, ovarian cancer and endometrial cancer.
References
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Journal ArticleDOI
Sperm morphologic features as a prognostic factor in in vitro fertilization.
Thinus F. Kruger,Roelof Menkveld,F. S. H. Stander,Carl Lombard,Jacobus P. Van der Merwe,Johannes A. van Zyl,Karen Smith +6 more
TL;DR: In this article, the authors conducted a prospective study in women with bilateral tubal damage to determine whether there is a prognostic value in the percentage normal sperm morphologic features in a human in vitro fertilization (IVF) program.
Journal ArticleDOI
Predictive value of abnormal sperm morphology in in vitro fertilization
Thinus F. Kruger,Anibal A. Acosta,Anibal A. Acosta,K.F. Simmons,K.F. Simmons,R.J. Swanson,R.J. Swanson,J.F. Matta,J.F. Matta,Sergio Oehninger,Sergio Oehninger +10 more
TL;DR: By evaluating sperm morphology with the proposed strict criteria, its predictive value in in vitro fertilization is enhanced.
Journal ArticleDOI
An analysis of sperm function in cases of unexplained infertility: conventional criteria, movement characteristics, and fertilizing capacity
R. John Aitken,Fiona S.M. Best,David W. Richardson,Ovrang Djahanbakhch,David Mortimer,A. Alan Templeton,Martin M. Lees +6 more
TL;DR: Of the conventional parameters of semen analysis examined, the most revealing was the morphologic character of the sperm, which was significantly poorer in the group with unexplained infertility than in the normal fertile control group and also showed a significant relationship with the presence of subnormal fertilizing capacity in the hamster egg assay.
Journal ArticleDOI
Sperm morphology assessment as an indicator of human fertilizing capacity.
B. Jane Rogers,Barbara J. Bentwood,Hana Van Campen,Gary Helmbrecht,Douglas Soderdahl,Ralph W. Hale +5 more
TL;DR: As a single parameter, decreased number of normal forms appears to be a good indicator for clinical infertility if in vitro fertilization testing is not available.
Journal ArticleDOI
A controlled comparison of the efficacy of clomiphene citrate in male infertility.
TL;DR: In this article, the clomiphene citrate (CC) was used to improve fertility in oligospermic men, and the pregnancy rates for the CC group and the placebo group were 9.09% and 44.44%, respectively.