Age-related changes in the thickness of the calcified zone and the number of tidemarks in adult human articular cartilage
LB Lane,PG Bullough +1 more
TLDR
It is suggested that remodelling of the bone ends occurs and that this process is accelerated with increasing age, particularly over the age of 60.Citations
More filters
Journal ArticleDOI
Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?
TL;DR: It is proposed that altered chondrocyte behavior and concomitant cartilage degradation result in a disease-amplifying loop, leading to a mixture of disease stages and cellular responses within an OA joint, which might be a therapeutic target to slow down further OA progression.
Journal ArticleDOI
Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis.
TL;DR: Understanding how the chondrocytes in adult human cartilage undergo phenotypic modulation and promote matrix destruction and abnormal repair in OA may to lead to identification of critical targets for therapy to block cartilage damage and promote effective cartilage repair.
Journal ArticleDOI
Anatomy and physiology of the mineralized tissues: Role in the pathogenesis of osteoarthrosis
TL;DR: The efficacy of bone anti-resorptive therapies for OA will depend upon whether the increased structural stiffness of the subchondral mineralized tissues predisposes the cartilage to deteriorate, whether theincreased bone turnover that occurs in OA is itself a causative factor, or whether the lower tissue elastic modulus offsets the increasedStructural stiffness ofthe subchONDral plate in an attempt to protect thecartilage from damage.
Journal ArticleDOI
Defining Spino-Pelvic Alignment Thresholds: Should Operative Goals in Adult Spinal Deformity Surgery Account for Age?
Renaud Lafage,Frank J. Schwab,Vincent Challier,Jensen K. Henry,Jeffrey L. Gum,Justin S. Smith,Richard A. Hostin,Christopher I. Shaffrey,Han Jo Kim,Christopher P. Ames,Justin K. Scheer,Eric O. Klineberg,Shay Bess,Douglas Burton,Virginie Lafage,Virginie Lafage +15 more
TL;DR: It is demonstrated that sagittal spino-pelvic alignment varies with age, and operative realignment targets should account for age, with younger patients requiring more rigorous alignment objectives.
Journal ArticleDOI
Effects of fluid-induced shear on articular chondrocyte morphology and metabolism in vitro
R. Lane Smith,B. S. Donlon,M Gupta,M Mohtai,Prajnan Das,Dennis R. Carter,John P. Cooke,Gary H. Gibbons,N I Hutchinson,David J. Schurman +9 more
TL;DR: It is demonstrated that articular chondrocyte metabolism responds directly to physical stimulation in vitro and suggests that mechanical loading may directly influence cartilage homeostasis in vivo.
References
More filters
Journal ArticleDOI
Osteoarthritis of the hip: a study of the nature and evolution of the disease.
TL;DR: To the authors' surprise it was found that daily use preserves rather than "wears out" articular cartilage; indeed inadequate use is the commonest cause of cartilage degeneration and ensuing vascular invasion.
Journal ArticleDOI
The transmission of load through the human hip joint
A.S. Greenwald,J.J. O'Connor +1 more
TL;DR: It is concluded that the function of joint incongruity is to allow the articular surfaces to come out of contact at light loads so that the cartilage may be exposed to synovial fluid for the purposes of nutrition and lubrication.
Journal ArticleDOI
The pattern of ageing of the articular cartilage of the elbow joint
J. W. Goodfellow,Peter Bullough +1 more
TL;DR: Evidence is presented that the almost inevitable degeneration of the radio-humeral joint in old age is related to the combination of rotation and hinge movements that occur at that joint.
Journal ArticleDOI
The relationship between degenerative changes and load-bearing in the human hip
TL;DR: The hip is shown to be anatomically incongruent, and the dome of the acetabulum, a predictable area of degeneration, is shown also to be an area of habitual non-use.
Journal ArticleDOI
Über die Arthritis deformans
TL;DR: Vergleicht man die in der Liter~tur erschienenen Arbeiten fiber die Gelenkerkrankungen, so ist as geradezu auffallend, wie verschwindend gering die pathologisehen Anatomen im Vergleich zu den Chirurgen darin vertreten sind.
Related Papers (5)
The vascularity and remodelling of subchondrial bone and calcified cartilage in adult human femoral and humeral heads. An age- and stress-related phenomenon
The morphology of the calcification front in articular cartilage. Its significance in joint function
PG Bullough,A Jagannath +1 more