Journal ArticleDOI
Agonal elevation in serum digoxin concentrations in infants and children long after cessation of therapy
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TLDR
In 11 of 15 profoundly sick, digitalized infants and children, elevation in serum digoxin concentration could be detected long after cessation of therapy, and this phenomenon concurred with a rapid deterioration of renal function.Abstract:
In 11 of 15 profoundly sick, digitalized infants and children, elevation in serum digoxin concentration could be detected long after cessation of therapy. This phenomenon concurred with a rapid deterioration of renal function. Because death of a digitalized child may be attributed to the glycoside itself, it is important to recognize that elevation in serum concentration to a potentially toxic level is a common pathophysiologic pattern.read more
Citations
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Journal ArticleDOI
Digoxin-specific antibody fragments: how much and when?
TL;DR: An approach to therapy is proposed, which is based on theoretical principles and evidence gleaned from currently available clinical data sets, and suggests that half the calculated loading dose, based on serum concentration, should be administered and the impact on clinical features observed; a second dose should be given in the event of recurrence of toxicity.
Journal ArticleDOI
Effect of endogenous digoxin-like substances on the interpretation of high concentrations of digoxin in children.
TL;DR: The data suggest that therapeutic drug monitoring using immunoassays of digoxin may be too inaccurate to detect potential toxic effects, and that much more weight should be focused on clinical monitoring.
Journal ArticleDOI
Digoxin-like immunoreactivity in early infantile death.
TL;DR: It is concluded that digoxin-like immunoreactivity is frequently found in infant sera, but levels are not specific to and are no higher in SIDS infants than infants dying of other conditions.
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