Alterations in the Local Myocardial Motion Pattern in Patients Suffering From Pressure Overload Due to Aortic Stenosis
Matthias Stuber,Markus B. Scheidegger,Stefan Fischer,Eike Nagel,F Steinemann,O M Hess,Peter Boesiger +6 more
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TLDR
Torsional behavior as observed in pressure- and volume-overloaded hearts is consistent with current theoretical findings and may contribute to a tendency toward diastolic dysfunction in patients with aortic stenosis.Abstract:
Background—MR tissue tagging allows the noninvasive assessment of the locally and temporally resolved motion pattern of the left ventricle. Alterations in cardiac torsion and diastolic relaxation of the left ventricle were studied in patients with aortic stenosis and were compared with those of healthy control subjects and championship rowers with physiological volume-overload hypertrophy. Methods and Results—Twelve aortic stenosis patients, 11 healthy control subjects with normal left ventricular function, and 11 world-championship rowers were investigated for systolic and diastolic heart wall motion on a basal and an apical level of the myocardium. Systolic torsion and untwisting during diastole were examined by use of a novel tagging technique (CSPAMM) that provides access to systolic and diastolic motion data. In the healthy heart, the left ventricle performs a systolic wringing motion, with a counterclockwise rotation at the apex and a clockwise rotation at the base. Apical untwisting precedes diasto...read more
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Measurement of ventricular torsion by two-dimensional ultrasound speckle tracking imaging
Yuichi Notomi,Peter Lysyansky,Randolph M. Setser,Takahiro Shiota,Zoran B. Popović,Maureen G. Martin-Miklovic,Joan A. Weaver,Stephanie J. Oryszak,Neil L. Greenberg,Richard D. White,James D. Thomas +10 more
TL;DR: The STI estimation of LVtor is concordant with those analyzed by tagged MRI and also showed good agreement with those by DTI (data derived from tissue velocity) and may make the assessment more available in clinical and research cardiology.
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New Noninvasive Method for Assessment of Left Ventricular Rotation Speckle Tracking Echocardiography
Thomas Helle-Valle,Jonas Crosby,Thor Edvardsen,Erik Lyseggen,Brage Amundsen,Hans-Jørgen Smith,Boaz D. Rosen,João A. C. Lima,Hans Torp,Halfdan Ihlen,Otto A. Smiseth +10 more
TL;DR: It is demonstrated that regional LV rotation and torsion can be measured accurately by STE, suggesting a new echocardiographic approach for quantification of LV systolic function.
Journal ArticleDOI
NF-κB activation as a pathological mechanism of septic shock and inflammation
Shu Fang Liu,Asrar B. Malik +1 more
TL;DR: The pathophysiology of sepsis and septic shock involves complex cytokine and inflammatory mediator networks and NF-κB activation is a central event leading to the activation of these networks.
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Twist Mechanics of the Left Ventricle: Principles and Application
TL;DR: An algorithm for routine application of LV twist in clinical differentiation of patterns of LV dysfunction encountered in day-to-day practice is presented and variations in LV twist encountered in different experimental and clinical situations are discussed.
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Enhanced ventricular untwisting during exercise: a mechanistic manifestation of elastic recoil described by Doppler tissue imaging.
Yuichi Notomi,Maureen G. Martin-Miklovic,Stephanie J. Oryszak,Takahiro Shiota,Dimitri Deserranno,Zoran B. Popović,Mario J. Garcia,Neil L. Greenberg,James D. Thomas +8 more
TL;DR: LV torsion and subsequent rapid untwisting appear to be manifestations of elastic recoil, critically linking systolic contraction to diastolic filling, which may assist efficient LV filling, an effect that appears blunted in HCM.
References
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Wall stress and patterns of hypertrophy in the human left ventricle.
TL;DR: The hypothesis that hypertrophy develops to normalize systolic but not diastolic wall stress is suggested, and it is proposed that increased syStolic tension development by myocardial fibers results in fiber thickening just sufficient to return the systolics stress (force per unit cross-sectional area) to normal.
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Human heart: tagging with MR imaging--a method for noninvasive assessment of myocardial motion.
TL;DR: Specified regions of the myocardium can be labeled in magnetic resonance (MR) imaging to serve as markers during contraction, thus permitting sampling of the entire contractile phase of the cardiac cycle.
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MR imaging of motion with spatial modulation of magnetization.
Leon Axel,Lawrence Dougherty +1 more
TL;DR: This technique can be used to study heart wall motion, to distinguish slowly moving blood from thrombus, and to study the flow of blood and cerebrospinal fluid.
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Improved myocardial tagging contrast
TL;DR: An improved method, called Complementary SPAtial Modulation of Magnetization (CSPAMM), which separates the component of the magnetization with the tagging information from the relaxed component by subtraction of two measurements with first a positive and then a negative tagging grid, greatly facilitates the automatic evaluation of the myocardial motion.
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Dissociation between left ventricular untwisting and filling. Accentuation by catecholamines.
Frank Rademakers,Maurice B. Buchalter,Walter J. Rogers,Elias A. Zerhouni,Myron L. Weisfeldt,James L. Weiss,Edward P. Shapiro +6 more
TL;DR: Untwisting occurs principally during isovolumic relaxation before filling and is markedly enhanced in speed and magnitude by catecholamines, which could represent an important mechanism for the release of potential energy stored in elastic elements during the systolic deformation.