Altered mitochondrial ribosomes in a cytoplasmic mutant of yeast.
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Mitochondria isolated from these mutants retain resistance in vitro, even if the mitochondrial membrane is damaged by freezing and thawing and this led Linnane et al. to propose that resistance in these mutants is due to an altered mitochondrial ribosome.About:
This article is published in FEBS Letters.The article was published on 1971-08-15 and is currently open access. It has received 48 citations till now. The article focuses on the topics: Mitochondrial ribosome & Mutant.read more
Citations
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Journal ArticleDOI
Mitochondrial Nucleic Acids
Piet Borst,L.A. Grivell +1 more
TL;DR: Present knowledge about the structure and function of mt DNA and its transcription products is briefly discussed with special emphasis on the unusual structure of mtDNA in Tetrahymena pyriformis and recent experiments on the possible import of mRNA into mitochondria.
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Biogenetic autonomy of mitochondria.
TL;DR: The Biogenetic Autonomy of Mitochondria as mentioned in this paper was first published in CRC Critical Reviews in Biochemistry: Vol. 1, No. 3, pp. 381-460.
Journal ArticleDOI
Biochemistry of protein synthesis in plants
TL;DR: Protein synthesis in mitochondria and chloroplasts: evidence from studies of inhibitors in wivo and products of protein synthesis in oitro are presented.
Journal ArticleDOI
Isolation of yeast mitochondrial ribosomes highly active in protein synthesis
TL;DR: An unusual feature of these ribosomes is their sensitivity to NH 4 Cl; 125 mM inhibits poly (U)-directed polyphenylalanine synthesis over 90 %.
References
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Journal ArticleDOI
Preparation and Some Properties of Yeast Mitochondria
TL;DR: Results showed that well preserved mitochondria isolated from Saccharomyces carlsbergensis could be stored for a long period of time without appreciable loss of phosphorylation activity and were completely insensitive to Amytal and rotenone.
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The biogenesis of mitochondria: 4. The differentiation of mitochondrial and cytoplasmic protein synthesizing systems in vitro by antibiotics
TL;DR: The mitochondria were found to have maximal rates of amino acid incorporation in an ATP-supported system similar to those currently used with cytoplasmic ribosomes, and the antibiotics chloramphenicol, lincomycin, erythromycin, spiramycin, carbomycin and oleandomycin have been shown to inhibit specifically amino acid incorporated by the mitochondrial system.
Journal ArticleDOI
Recombination of mitochondrial drug-resistance factors in Saccharomyces cerevisiae.
D.Y. Thomas,D. Wilkie +1 more
TL;DR: R&assortment of mitochondrially-located drug-resistance factors in the vegetative progeny of individual zygotes will be described and evidence of a recombinational process involving the genetic material of the organelle is provided.
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Ribosome-catalyzed peptidyl transfer: substrate specificity at the P-site.
Journal ArticleDOI
Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes
TL;DR: An assay for substrate-interaction at the P-site is reported, based on the measurement of binding of CACCA-Leu-Ac to 50 S subunits in the presence of ethanol, which suggests that the interaction is blocked by certain antibiotic inhibitors of peptidyl transferase but not others.
Related Papers (5)
Recombination of mitochondrial drug-resistance factors in Saccharomyces cerevisiae.
D.Y. Thomas,D. Wilkie +1 more