Journal ArticleDOI
An organic psychosis due to a venlafaxine-propafenone interaction.
F Pfeffer,M Grube +1 more
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TLDR
An extraordinary case of an organic psychosis during the treatment of a patient with a bipolar affective disorder causes markedly increased serum levels of venlafaxine correlating with unexpected psychopathological changes, suggesting there is a potentially dangerous interaction between venl Lafaxine and propafenone.Abstract:
Objective An extraordinary case of an organic psychosis during the treatment of a patient with a bipolar affective disorder. Methods Clinical observation and further investigations including monitoring of serum levels (case report). Results A significant interaction between venlafaxine and propafenone causes markedly increased serum levels of venlafaxine correlating with unexpected psychopathological changes. Conclusions There is a potentially dangerous interaction between venlafaxine and propafenone. Serum levels of venlafaxine should be monitored if propafenone is added.read more
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Journal ArticleDOI
Venlafaxine—Propafenone Interaction Resulting in Hallucinations and Psychomotor Agitation
Pietro Gareri,Pasquale De Fazio,Luca Gallelli,Salvatore De Fazio,Alessandro Davoli,Giuseppe Seminara,Antonino Maria Cotroneo,Giovambattista De Sarro +7 more
TL;DR: T careful evaluation of concomitant treatment with CYP2D6 or P-glycoprotein inhibitors (eg, propafenone) and, when possible, venlafaxine serum concentration monitoring is suggested to prevent the onset of clinical disturbances during venl Lafaxine treatment.
Journal ArticleDOI
Antidepressant-induced akathisia-related homicides associated with diminishing mutations in metabolizing genes of the CYP450 family
TL;DR: The authors suggest that the key lies in understanding the interplay between the subject’s CYP450 genotype, substrate drugs and doses, co-prescribed inhibitors and inducers and the age of the subject.
Journal ArticleDOI
Adverse effects of interactions between antidepressants and medications used in treatment of cardiovascular disorders.
TL;DR: Each decision regarding combination of a particular antidepressant with a medication used in treatment of cardiovascular disorders should be preceded by a detailed analysis of safety and risk-benefit ratio, and also be associated with the search for the safest, alternative combinations of the above-mentioned medications.
Journal ArticleDOI
Venlafaxine-induced delirium
Jacob Alexander,Ann Nillsen +1 more
TL;DR: A third case of venlafaxine-induced delirium in the absence of serotonergic syndrome or hyponatraemia is reported, suggesting that esomeprazole was unlikely to have been the cause ofDelirium.
References
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Journal ArticleDOI
Introduction of a Composite Parameter to the Pharmacokinetics of Venlafaxine and its Active O‐Desmethyl Metabolite
Karen J. Klamerus,Kathleen Moloney,Richard L. Rudolph,Samuel F. Sisenwine,William J. Jusko,Soong T. Chiang +5 more
TL;DR: Venlafaxine is a structurally novel, nontricyclic compound that is being evaluated for the treatment of various depressive disorders as discussed by the authors, and it has been shown to have linear dose proportionality up to 75 mg q8h.
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The safety and tolerability of venlafaxine hydrochloride: analysis of the clinical trials database
TL;DR: The tolerability and safety profiles of venlafaxine were similar to those previously reported for selective serotonin reuptake inhibitors and in the elderly did not differ significantly from that observed in younger patients.
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Metabolic disposition of 14C-venlafaxine in mouse, rat, dog, rhesus monkey and man
TL;DR: The metabolic disposition of venlafaxine has been studied in mouse, rat, dog, rhesus monkey and man after oral doses of 14C-venlafxine as the hydrochloride, indicating extensive absorption from the GI tract and renal excretion.
Journal ArticleDOI
Isolated venlafaxine-induced serotonin syndrome
TL;DR: A patient is described with a classic presentation of serotonin syndrome induced solely by a venlafaxine overdose, a potentially fatal complication of serotonergic drug therapy.