Androgen Receptors STEROID AND TISSUE-SPECIFIC RETENTION OF A 17β-HYDROXY-5α-ANDROSTAN-3-ONE-PROTEIN COMPLEX BY THE CELL NUCLEI OF VENTRAL PROSTATE
Senmaw Fang,Shutsung Liao +1 more
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TLDR
The steroid- and tissue-specificity of the cell-free systems strongly suggests that 5α-dihydrotestosterone plays a central role in the retention of an androgen receptor protein by prostate nuclei in vivo.About:
This article is published in Journal of Biological Chemistry.The article was published on 1971-01-10 and is currently open access. It has received 291 citations till now. The article focuses on the topics: Androgen receptor & Receptor.read more
Citations
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Journal ArticleDOI
Estrogen Receptor in a Human Cell Line (MCF-7) from Breast Carcinoma
TL;DR: A stable cell line derived by pleural effusion from a breast cancer patient has been demonstrated to contain significant amounts of 17β-estradiol receptor, which has a Kd equal to 2.5 nm, a sedimentation constant of 4.0 S, and a mechanism capable of transporting the 17 β-ESTradiol into the nucleus.
Journal ArticleDOI
Progesterone-binding Components of Chick Oviduct III. CHROMATIN ACCEPTOR SITES
TL;DR: Under optimal conditions, the progesterone-oviduct receptor complex displays more extensive binding to oviduct chromatin than to the chromatins of chick spleen, heart, mature erythrocytes, or liver, which indicates that the target tissue chromatin may contain acceptor sites for the steroid hormone-receptor complex.
Book ChapterDOI
Steroid Hormone Receptors
TL;DR: The dependence of human cancers on hormones, the detection and characterization of steroid receptor interactions, and the physiological and pharmacological implications of steroid hormone receptors are discussed.
Journal ArticleDOI
Progesterone-binding components of chick oviduct. IV. Characterization of purified subunits.
W T Schrader,Bert W. O'Malley +1 more
TL;DR: The cytoplasmic progesterone-binding proteins of chick oviduct are shown to consist of two major 4 S fractions which occur in equal amounts, suggesting that the same class of hormonebinding site is involved on both A and B.
Book ChapterDOI
Steroid hormone receptors
Etienne-Emile Baulieu,Michel Atger,Martin Best-Belpomme,Pierre Corvol,Jean-Claude Courvalin,Jan Mester,Edwin Milgrom,Paul Robel,Henri Rochefort,Denise De Catalogne +9 more
TL;DR: In this paper, different aspects of steroid hormone receptors are discussed, and the kinetic parameters of the binding reaction of the uterine receptor-estradiol are also studied, and it is found that when estradiol, estrone, and estriol are compared, the rate of dissociation of receptor steroid complexes is similar for the three steroids.
References
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Journal ArticleDOI
Isolation of pure and unaltered liver nuclei morphology and biochemical composition.
TL;DR: It is shown that the contamination of the nuclei by cytoplasmic structures is one of the main difficulties encountered in the isolation of the nuclear fraction and an accurate count of contaminants is necessary, especially in the study of thenuclear composition.
Journal ArticleDOI
The conversion of testosterone to 5-alpha-androstan-17-beta-ol-3-one by rat prostate in vivo and in vitro.
TL;DR: It has been shown that in the presence of a NADPH2-generating system prostatic nuclei convert testosterone to dihydrotestosterone, whereas prostatic cytoplasm reduces dihydotestosterone to androstandiol.
Journal ArticleDOI
A two-step mechanism for the interaction of estradiol with rat uterus.
TL;DR: Evidence is presented that the 9.5S receptor is extranuclear and involved in estrogen uptake, whereas the nuclear 5S complex, probably responsible for hormone retention and growth initiation, is formed from the 9-5S complex by a process which consumes 9.
Journal ArticleDOI
Selective retention of dihydrotestosterone by prostatic nuclei
K. M. Anderson,Shutsung Liao +1 more
TL;DR: Nuclear chromatin of prostate, but not other tissues which are insensitive to androgen, contains an androgen receptor which can selectively retain dihydrotestosterone (DHT, 5α-androstane-17β-ol-3-one)—the most potent endogenous androgen for the growth of ventral prostate of rat13,14.
Journal ArticleDOI
Receptor Proteins for Androgens ON THE ROLE OF SPECIFIC PROTEINS IN SELECTIVE RETENTION OF 17β-HYDROXY-5α-ANDROSTAN-3-ONE BY RAT VENTRAL PROSTATE IN VIVO AND IN VITRO
TL;DR: The antagonistic action of antiandrogens strongly supports the contention that the binding of 5α-dihydrotestosterone by proteins described in this paper is germane to the stimulation of prostate growth and function by androgens.