Antibacterial activities of selected Cameroonian spices and their synergistic effects with antibiotics against multidrug-resistant phenotypes
TLDR
The results of the antibacterial assays indicated that all tested extracts exert antibacterial activities, with the minimum inhibitory concentration values varying from 32 to 1024 μg/ml.Abstract:
The emergence of multi-drug resistant (MDR) phenotypes is a major public health problem today in the treatment of bacterial infections. The present study was designed to evaluate the antibacterial activities of the methanol extracts of eleven Cameroonian spices on a panel of twenty nine Gram negative bacteria including MDR strains. The phytochemical analysis of the extracts was carried out by standard tests meanwhile the liquid micro-broth dilution was used for all antimicrobial assays. Phytochemical analysis showed the presence of alkaloids, phenols and tannins in all plants extracts. The results of the antibacterial assays indicated that all tested extracts exert antibacterial activities, with the minimum inhibitory concentration (MIC) values varying from 32 to 1024 μg/ml. The extracts from Dichrostachys glomerata, Beilschmiedia cinnamomea, Aframomum citratum, Piper capense, Echinops giganteus, Fagara xanthoxyloides and Olax subscorpioidea were the most active. In the presence of efflux pump inhibitor, PAsN, the activity of the extract from D. glomerata significantly increased on 69.2% of the tested MDR bacteria. At MIC/5, synergistic effects were noted with the extract of D. glomerata on 75% of the tested bacteria for chloramphenicol (CHL), tetracycline (TET) and norfloxacin (NOR). With B. cinnamomea synergy were observed on 62.5% of the studied MDR bacteria with CHL, cefepime (FEP), NOR and ciprofloxacin (CIP) and 75% with erythromycin (ERY). The overall results provide information for the possible use of the studied extracts of the spices in the control of bacterial infections involving MDR phenotypes.read more
Citations
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Plant-derived antimicrobial compounds: alternatives to antibiotics.
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Antibacterial and Antifungal Activities of Spices
TL;DR: Spices have a great potential to be developed as new and safe antimicrobial agents and this review summarizes scientific studies on the antibacterial and antifungal activities of several spices and their derivatives.
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Antibacterial activities of selected edible plants extracts against multidrug-resistant Gram-negative bacteria
Doriane E. Djeussi,Jaurès A. K. Noumedem,Jackson A. Seukep,Aimé G. Fankam,Igor K. Voukeng,Simplice B. Tankeo,Antoine H.L. Nkuete,Victor Kuete +7 more
TL;DR: The results of the present work provide useful baseline information for the potential use of the studied edible plants in the fight against both sensitive and MDR phenotypes.
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HPLC-DAD finger printing, antioxidant, cholinesterase, and α-glucosidase inhibitory potentials of a novel plant Olax nana.
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Antimicrobial Activities of African Medicinal Spices and Vegetables
TL;DR: The role of some African spices and vegetable as antibiotic-potentiating agents was also discussed as well as their ability to fight bacterial multidrug resistance.
References
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TL;DR: The current status of botanical screening efforts, as well as in vivo studies of their effectiveness and toxicity, are summarized and the structure and antimicrobial properties of phytochemicals are addressed.
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Medicinal plants and traditional medicine in Africa
TL;DR: In this article, the authors discuss the use of traditional medicine in Africa and its application in the field of medicinal plants and traditional medicine, including traditional medicine and traditional plants in Africa.
Plant products as antimicrobial agents
Daciana Ciocan,Bara Ioan +1 more
TL;DR: Plants produce a diverse array of secondary metabolites, many of which have antimicrobial activity, which occur as inactive precursors and are activated in response to tissue damage or pathogen attack.
Journal ArticleDOI
A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteria
TL;DR: A micro-dilution technique was developed using 96-well microplates and tetrazolium salts to indicate bacterial growth and was useful in screening plants for antimicrobial activity and for the bioassay-guided isolation of antimicrobial compounds from plants.
Journal ArticleDOI
Potential of Cameroonian plants and derived products against microbial infections: a review.
TL;DR: Many plant species are used in traditional medicine in Cameroon to treat infectious diseases, and several interesting openings have originated for further inquiry following IN VITRO antimicrobial activity evaluation.