Open Access
Antihyperlipidemic activity of seed extract of Piper attenuatum in triton X- 100 induced hyperlipidemia in rats
Gaurav K. Soni,Tripti Verma +1 more
Reads0
Chats0
TLDR
It was found that Piperine & Piperlongumin the active constituent of the plant was respons ible for the Anti-Hyperlipidemic activity because this constitue nt have the ability to reduce the Total Cholesterol & Total Triglyceride level in rats.Abstract:
Piper attenuatum is a potent medicinal plant in the Indian systems of medicine. Piper attenuatum havin g Piperine, Piperlonguminine and other active constituents whic h are used as muscle relaxant, central nervous syst em depressant, in headache and as insecticide agent ag ainst Musca domestica. Piperine reduced the total b ody temperature and display analgesic, and anti-inflamm atory activities. The aim of present study is to de termine the Anti-Hyperlipidemic activity of Ethanolic seed extr act of plant Piper attenuatum (Linn.) B. Ham. (Fam. Piperaceae). Piperine was the first amide to be isolated from Pi per species. Ethanolic extracts of Piper attenuatum with a dose of 200 mg/kg exhibited significant Anti-Hyperlipidemic activity in Triton X-100 Induced Hyperlipidemia in rats (P<.05). It was found that Piperine & Piperlongumin ine the active constituent of the plant was respons ible for the Anti-Hyperlipidemic activity because this constitue nt have the ability to reduce the Total Cholesterol & Total Triglyceride level in rats. Fenofibrate was used as standard drug (65 mg/kg). The total time period of this study was one week.read more
Citations
More filters
Journal ArticleDOI
Hypolipidemic and antioxidant effects of the Methanolic stem bark extract of Anacardium occidentale Linn. In triton-X 100 induced hyperlipidemic rats
Abstract: Anacardium occidentale stem bark has been reportedly used in the management of diabetes, inflammatory and oxidative stress conditions in folk medicine. In this study, the methanolic stem bark extract of Anacardium occidentale (MEAO) was evaluated for its hypolipidemic and antioxidant activities. Extract was obtained from powdered stem bark of A. occidentale by maceration in methanol (80%). Phytochemical screening, phenolic contents and free radical scavenging activity were determined in the extract. Animals were injected with Triton-X 100 (100 mg/kg, i.p.) to induce hyperlipidemia. MEAO (100, 200 and 400 mg/kg) and atorvastatin (10 mg/kg) were administered orally for 7 days. Serum, liver and heart tissue homogenates were used for determination of lipid profile and antioxidant assays. Alkaloids, flavonoids, saponins, tannins, anthraquinones, terpenoids and cardiac glycosides were found to be present in MEAO. Total phenolic content (TPC) and total flavonoid content (TFC) of MEAO were 129 mg GAE/g sample and 93.7 mg RE/g sample respectively. MEAO showed potent antioxidant activity with IC50 value of 42.44 ± 0.16 compared to ascorbic acid with 121.7 ± 0.04. Administration of MEAO resulted in a significant (p <0.05) decrease in Triton-X 100 induced serum total cholesterol, triglycerides, LDL-C, VLDL-C, atherogenic index and increase in HDL-C. In addition, MEAO also showed antioxidant activity by significantly reducing lipid peroxidation and preventing the depletion of GSH in hepatic and cardiac tissues. The results suggest that A. occidentale stem bark contains phytochemicals with hypolipidemic and antioxidant properties, justifying its use in ethnomedicine.
Journal ArticleDOI
Hypolipidemic Effect of Chrysophyllum albidum Peel Extract and Its Underlying Antioxidant Mechanisms in Normal and Triton-X-100-Induced Hyperlipidemic Rats.
TL;DR: CAPEE showed hepatoprotective as well as antioxidant activity in serum and liver of normal and hyperlipidemic rats and possesses antioxidants and hypolipidemic properties.
References
More filters
Book
Indian Medicinal Plants
TL;DR: Indian medicinal plants/, Indian medicinal plants /, مرکز فناوری اطلاعات و اصاع رسانی, کδاوρزی