Open AccessJournal Article
Antinociceptive effects of the essential oil of Dracocephalum kotschyi in the mouse writhing test.
Reads0
Chats0
TLDR
It is confirmed that antinociceptive properties of D. kotschyi are comparable to those of hyoscine and indomethacin used, which is necessary to find out a place for it in antispasmodic therapies in human.Abstract:
PURPOSE. Dracocephalum kotschyi is a wild-growing flowering plant belonging to the family Labiatae and found abundantly in Iran. This plant has been used in Iran folk medicine as analgesic. METH- ODS. The Dracocephalum kotschyi essential oil was iso- lated and studied on writhing test a visceral pain model in mice. Different constituents of the essential oil were determined by gas chromatography mass spectropho- tometry technique. RESULTS. Limonene, verbenone, α-terpineol, perillyl alcohol and caryophyllene were the major constituents of the essential oil. The essential oil in doses (mg kg -1 ) used 12.5 (13.9%, P<0.05), 25 (43.1%, P<0.01), 50 (68.7%, P<0.01), 75 (39.8%, P<0.01) induced significant reduction in pain response when compared to control. The ED 50 was 61.61 mg kg - 1 . Hyoscine (1 mg kg -1 ) and indomethacin (5 mg kg -1 ) induced significant (P<0.01) reductions (74.9% and 76.7% respectively) in pain response in comparison to control. CONCLUSION. This study confirms that antinociceptive properties of D. kotschyi are compara- ble to those of hyoscine and indomethacin used. Pres- ence of limonene and α-terpineol might be responsible for antinociceptive properties of this essen- tial oil. Further studies are necessary to find out a place for it in antispasmodic therapies in human.read more
Citations
More filters
Journal ArticleDOI
Labiatae Family in folk Medicine in Iran: from Ethnobotany to Pharmacology
TL;DR: A number of pharmacological and experimental studies have been reviewed, which confirm some of the traditional applications of the Labiatae family and also show the headline for future works on this family.
Journal ArticleDOI
β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties
TL;DR: The selective activation of CB2 may be considered a novel strategy in pain treatment, devoid of psychoactive side effects associated with CB1 stimulation, and BCP as selective CB2 activator may be taken into account as potential natural analgesic drug.
Journal ArticleDOI
β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice.
Amine Bahi,Shamma Al Mansouri,Elyazia Al Memari,Mouza Al Ameri,Syed M. Nurulain,Shreesh Ojha +5 more
TL;DR: Results indicated that adult mice receiving BCP showed amelioration of all the parameters observed in the EPM test, and pre-administration of the CB2 receptor antagonist AM630 fully abrogated the anxiolytic and the anti-depressed effects of BCP.
Journal ArticleDOI
A Systematic Review of the Potential Herbal Sources of Future Drugs Effective in Oxidant-Related Diseases
TL;DR: Amongst these useful herbs, some like Cinnamon, Silybum marianum, Garlic, Nigella, and Echium seem potential targets of future effective drugs for diseases in which free radical damage play a pathogenical role.
Journal ArticleDOI
Limonene - a Review: Biosynthetic, Ecological and Pharmacological Relevance:
Paul Erasto,Alvaro M. Viljoen +1 more
TL;DR: Limonene is one of the most common compounds found in the essential oils of aromatic plants as discussed by the authors, and the occurrence of this monoterpene hydrocarbon in various plant genera could be attributed to its precur...
References
More filters
Book
Drug discovery and evaluation : pharmacological assays
TL;DR: Thoroughly revised and expanded to two volumes, this successful reference offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs.
Journal ArticleDOI
Antinociceptive effects of Teucrium polium L total extract and essential oil in mouse writhing test.
TL;DR: This study confirms the antivisceral pain properties of T. polium comparable to those of hyoscine and indomethacin and suggests a good place for it in antispasmodic therapies in human.
Journal ArticleDOI
Evaluation of the immunomodulatory effects of five herbal plants.
TL;DR: In vitro study revealed the capacity of all the extracts except Dracocephalum to enhance the proliferation of lymphocytes after stimulation with the allogenic cells.
Journal Article
Evaluation of anti-inflammatory activity of essential oils from two Asteraceae species.
Mariana C. Souza,Antonio Carlos Siani,Mônica Freiman de Souza Ramos,O. Menezes-De-Lima,Mariana Henriques +4 more
TL;DR: The essential oils from two Asteraceae species, Porophyllum ruderale and Conyza bonariensis, were screened for anti-inflammatory activity and, when administered orally, were able to inhibit the LPS-induced inflammation including cell migration; with a similar effect being observed for pure limonene.