scispace - formally typeset
Open AccessJournal ArticleDOI

Apolipoprotein B variant derived from rat intestine.

TLDR
A variant of apolipoprotein B has been observed in the lymph lipoproteins of rats, in the plasma VLDL and LDL of rats fed a high-fat, high-cholesterol diet.
Abstract
A variant of apolipoprotein B has been observed in the lymph lipoproteins [chylomicrons, very low density lipoproteins (VLDL), and low density lipoproteins (LDL)] of rats, in the plasma VLDL of fed rats, and in the plasma VLDL and LDL of rats fed a high-fat, high-cholesterol diet. It is the sole apolipoprotein B in the chylomicrons and VLDL of lymph. It differs from the apolipoprotein B of normal plasma LDL in its immunological properties and in its apparent molecular weight from electrophoresis on 3.5% NaDodSO4/polyacrylamide gel.

read more

Citations
More filters
Journal ArticleDOI

Plasma lipoproteins: apolipoprotein structure and function.

TL;DR: Future studies will rely heavily on the use of recombinant DNA technology and site-specific mutagenesis to elucidate further the correlations between structure and function and the role of specific apolipoproteins in lipoprotein metabolism.
Journal ArticleDOI

Regulation of plasma cholesterol by lipoprotein receptors

TL;DR: The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man.
Journal ArticleDOI

Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon.

TL;DR: Data indicate that approximately 85% of the intestinal mRNAs terminate within approximately 0.1 to 1.0 kilobase downstream from the stop codon, which might have implications for cryptic polyadenylation signal recognition and RNA processing.
Journal ArticleDOI

Defective lipoprotein receptors and atherosclerosis. Lessons from an animal counterpart of familial hypercholesterolemia.

TL;DR: In 1913, Anitschkow fed cholesterol to rabbits, and thereby demonstrated that a high blood level of cholesterol can produce atherosclerosis in animals just as it can in human beings.
Journal ArticleDOI

Apolipoprotein b: structural and metabolic heterogeneity

TL;DR: The large number of protein species present in the lipoprotein complexes in blood suggests a number of biochemical roles of proteins in lipoproteins metabolism and perhaps also in nontransport functions.
Related Papers (5)